Ablative and acoustic response of pulsed UV laser-irradiated vascular tissue in a liquid environment

Cross, F. W.; Al-Dhahir, Rashid K.; Dyer, P. E.

doi:10.1063/1.341707

Cited by 58 publications

(31 citation statements)

References 23 publications

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“…The absorption coefficient, μ a , can be estimated either from the maximum amplitude of the signal, if the PA efficiency,Γ, and the incident fluence, Φ 0 , are known, or by fitting a curve to the exponentially decaying slope. [49][50][51] More recently, a frequency domain method for quantification of μ a has been proposed by Guo et al 52 It too assumes a homogeneous, nonscattering medium, and the starting point is that the measured data will be pðtÞ as given in Eq. (21) convolved with a frequency-dependent transfer function that will depend on both the acoustic absorption and the measurement system frequency response.…”

Section: Homogeneous Nonscattering Medium: Beer's Lawmentioning

confidence: 99%

Quantitative spectroscopic photoacoustic imaging: a review

et al. 2012

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Abstract. Obtaining absolute chromophore concentrations from photoacoustic images obtained at multiple wavelengths is a nontrivial aspect of photoacoustic imaging but is essential for accurate functional and molecular imaging. This topic, known as quantitative photoacoustic imaging, is reviewed here. The inverse problems involved are described, their nature (nonlinear and ill-posed) is discussed, proposed solution techniques and their limitations are explained, and the remaining unsolved challenges are introduced.

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Section: Homogeneous Nonscattering Medium: Beer's Lawmentioning

confidence: 99%

Quantitative spectroscopic photoacoustic imaging: a review

et al. 2012

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“…The theoretical background for multiplexing goes back to the early 1980s and is based on the assumption that excimer laser ablation induces a mass explosion of the irradiated atherosclerotic target rather than cutting it slice by slice by molecular photodecomposition [11,12]. As we have shown, pressure waves do accompany each laser pulse below and above the ablation threshold.…”

Section: Discussionmentioning

confidence: 95%

Perspectives of coronary excimer laser angioplasty: Multiplexing, saline flushing, and acoustic ablation control

et al. 1997

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“…In the extension of this method to biomedical diagnosis [36], the biological tissue under test absorbs laser light and generates ultrasound detectable by a conventional piezoelectric transducer. The information carried by these ultrasonic signals is mainly related to the optical absorption properties of tissues, and the adoption of high-frequency, broad bandwidth receiver might permit to strongly enhance the actual diagnostic capability.…”

Section: B Opto-acoustic Spectroscopymentioning

confidence: 99%

Toward virtual biopsy through an all fiber optic ultrasonic miniaturized transducer: a proposal

Acquafresca

Biagi

Masotti

et al. 2003

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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The present generation of devices based on opto-acoustic and acousto-optic conversion lets us foresee the possibility of realizing complete miniaturized transmitting-receiving transducers, able to generate and detect wideband ultrasounds by laser light. In the present paper, a miniaturized ultrasonic transducer entirely based on fiber optic technology is proposed. Such a device springs from the conjunction between our research, which has produced a highly efficient fiber optic opto-acoustic source, with the results obtained by other researchers concerning the realization of an ultrasonic receiver based on optical interferometry. Making use of the thermo-elastic effect for ultrasound generation, a source of ultrasound can be obtained by coupling a fiber optic to pulsed laser, if a film capable of absorbing laser light is placed onto fiber end. Starting from these remarks, we propose an efficient opto-acoustic source, able to generate pressure pulses with amplitude of the order of 10 4 Pa and bandwidth extending up to 40 MHz and beyond by using graphite materials as absorbing film. This solution makes use of a low-power pulsed laser as optical source possible. An ultrasonic receiving element was realized placing a Fabry-Perot cavity over the tip of a fiber optic. The cavity thickness modulation induced by ultrasonic beam is detected by an interferometer optical technique. We have realized a prototype of a receiving device that exhibits a sensitivity comparable with that of piezoelectric devices (10-100 nV/Pa) and an almost flat bandwidth extending up to 20 MHz or more. The extreme miniaturization of the resulting ultrasonic transducer, together with its wide ultrasonic frequency bandwidth, is the first step toward ultrasonic tissue biopsy. In this paper, before discussing the problem of constructing a complete ultrasonic transducer composed by a transmitter and receiver, the results carried out in these fields during the last decade are reviewed.

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Ablative and acoustic response of pulsed UV laser-irradiated vascular tissue in a liquid environment

Cited by 58 publications

References 23 publications

Quantitative spectroscopic photoacoustic imaging: a review

Quantitative spectroscopic photoacoustic imaging: a review

Perspectives of coronary excimer laser angioplasty: Multiplexing, saline flushing, and acoustic ablation control

Toward virtual biopsy through an all fiber optic ultrasonic miniaturized transducer: a proposal

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