Ablative Fractional Carbon Dioxide Laser in the Treatment of Chronic, Posttraumatic, Lower-Extremity Ulcers in Elderly Patients

Phillips, Tania J.; Morton, Laurel M.; Uebelhoer, Nathan S.; Dover, Jeffrey S.

doi:10.1001/jamadermatol.2015.0645

Cited by 27 publications

(21 citation statements)

References 9 publications

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“…Ablative fractional laser resurfacing (AFR) is a well‐established treatment modality for scar mitigation and revision, and the technique has also recently been shown to help acclerate healing of chronic wounds . AFR has been reported to modulate and influence the wound healing enviornment through various growth factors, matrix matalloproteinases, and changes in collagen architecture .…”

Section: Discussionmentioning

confidence: 99%

“…Current treatment options for CL are limited, and there is a paucity of research for proven therapies. Ablative fractional laser resurfacing (AFR) represents a novel treatment option for CL wounds and may address treatment challenges commonly encountered in CL treatment including concurrent accelerated healing of ulcerative wounds, improved delivery of topical medications, and scar mitigation . Here we report marked, rapid improvement in a distal extremity chronic wound caused by CL after two treatments with AFR in combination with topical paromomycin.…”

Section: Introductionmentioning

confidence: 95%

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Ablative fractional laser resurfacing with topical paromomycin as adjunctive treatment for a recalcitrant cutaneous leishmaniasis wound

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Ablative fractional laser resurfacing with topical paromomycin as adjunctive treatment for a recalcitrant cutaneous leishmaniasis wound

et al. 2015

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“…In another case series done by Phillips et al, CO 2 laser was used in the treatment of posttraumatic slow healing wounds in three elderly patients. In their report each wound was healed by 60% or greater within 3 weeks [47]. In an interesting article reepithelialization and accelerated wound healing within 4 weeks was reported in one recessive dystrophic epidermolysis bullosa (RDEB) patient with CO 2 laser without blistering or other adverse effects [48].…”

Section: Co 2 Laser and Wound Healingmentioning

confidence: 99%

Physical Modalities in the Management of Wound(s)

Feily¹,

Moeineddin²,

Mehraban³

2016

Wound Healing - New Insights Into Ancient Challenges

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Wound is caused by disruption of the integrity of body skin as a result of environmental or medical factors. Managing chronic and refractory wounds is a significant dilemma physicians are facing. Large varieties of treatment modalities have been used to enhance wound healing among which were different medicines, surgical procedures, physical therapy, hyperbaric oxygen therapy, and physical modalities such as laser and shockwave. In this chapter, the authors discuss physical modalities that are most used in the management of wound healing with a focus on lasers, shockwaves, photodynamic therapy, UVB therapy, and lights and describe some important experimental and clinical trials that have been done in this regard with an attempt to explain their mechanisms.

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“…There have been a few reports on using fractional resurfacing to treat chronic wounds, with enhanced healing after fractional laser treatments reported in an animal study of delayed diabetic healing 102 and several clinical cases of chronic wounds associated with scars, [103][104][105] epidermolysis bullosa, 105 and traumatic lesions in the elderly. 106 More extensive studies are needed to determine if this treatment is broadly applicable to different chronic wound types.…”

Section: Potential Utility In Chronic Wound Preventionmentioning

confidence: 99%

When Wounds Are Good for You: The Regenerative Capacity of Fractional Resurfacing and Potential Utility in Chronic Wound Prevention

Leaker

Fuchs

Tam

2019

Advances in Wound Care

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Fractional resurfacing involves producing arrays of microinjuries on the skin, by thermal or mechanical means, to trigger tissue regeneration. Originally developed for cosmetic enhancement, fractional resurfacing induces a broad array of improvements in the structural and functional qualities of the treated skin and is especially effective at returning defective skin to a more normal state. In addition to fascinating questions about the nature of this remarkable regenerative capacity, there may be potential utility in ulcer prevention by halting or even reversing the progressive decline in overall skin quality that usually precedes chronic wound development. Recent Advances: Photoaging and scarring are the two skin defects most commonly treated by fractional resurfacing, and the treatment produces profound and long-lasting improvements in skin quality, both clinically and at the cellular/ histologic level. Chronic wounds usually occur in skin that is compromised by various pathologic factors, and many of the defects found in this ulcer-prone skin are similar to those that have seen improvements after fractional resurfacing. Critical Issues: The mechanisms responsible for the regenerative capacity of fractional resurfacing are mostly unknown, as is how ulcer-prone skin, which is usually afflicted by stressors external to the skin tissue itself, would respond to fractional resurfacing. Future Directions: Better understanding of the cellular and molecular mechanisms underlying the unique healing response to fractional resurfacing could reveal fundamental information about adult tissue regeneration, lead to improvements in current applications, as well as new therapies in other pathologic conditions.

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Ablative Fractional Carbon Dioxide Laser in the Treatment of Chronic, Posttraumatic, Lower-Extremity Ulcers in Elderly Patients

Abstract: Fractional carbon dioxide laser treatment appeared to accelerate healing in each of these posttraumatic wounds. It may be a helpful adjunct in nonhealing posttraumatic wounds.

Cited by 27 publications

References 9 publications

Ablative fractional laser resurfacing with topical paromomycin as adjunctive treatment for a recalcitrant cutaneous leishmaniasis wound

Ablative fractional laser resurfacing with topical paromomycin as adjunctive treatment for a recalcitrant cutaneous leishmaniasis wound

Physical Modalities in the Management of Wound(s)

When Wounds Are Good for You: The Regenerative Capacity of Fractional Resurfacing and Potential Utility in Chronic Wound Prevention

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