he current epidemic of opioid-related mortality has shed light on poor opioid prescribing practices after abdominopelvic surgery. Research has demonstrated that substantial variations exist in the amount of opioid prescribed at discharge [1][2][3] and that opioid prescriptions are often in excess of actual patient requirements. 1,[3][4][5] These findings are particularly concerning given that more than 70% of patients store their excess opioids in unlocked locations and do not properly dispose of them. 6 Such easily accessible supplies of prescription opioids may lead to unintended harms, such as opioid misuse 7 and accidental overdoses. 8 Moreover, there is growing awareness that a substantial proportion of opioid-naive patients will become long-term users of opioids after initial exposure in the immediate postoperative period. 9-13 Because long-term opioid use may lead to physiological dependence and misuse, prevention in the early phases of perioperative care is important. However, abdominal surgeons may not be aware of the risk of long-term opioid use, and they infrequently perform a risk assessment in their patients. 14 A lack of guidance for surgeons has been cited as a major factor contributing to the suboptimal nature of current postsurgical opioid prescribing practices. 1,14,15 Guidelines published by the American Society of Anesthesiologists and the American Pain Society provide general recommendations on the use of opioids in managing pain during the inpatient postoperative period, but they failed to explicitly address how clinicians should prescribe opioids at discharge. 16,17 Guidelines for the treatment of acute pain from the Centers for Diseases IMPORTANCE The prescription of opioids at discharge after abdominopelvic surgery is variable and often excessive. A lack of guidance for abdominopelvic surgeons may explain the suboptimal nature of current prescribing practices.OBJECTIVE To systematically review existing recommendations on the prescription of opioids at discharge, the appropriate disposal of opioids, and the prevention of chronic postsurgical opioid use after abdominopelvic surgery.EVIDENCE REVIEW This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. From January 2010 to December 2018, a search of MEDLINE, PsycINFO, HealthSTAR, Embase, and the difficult to locate and unpublished (ie, gray) literature was performed using a peer-reviewed strategy with variations of the terms opioid, surgery, and guideline to identify English-language documents that contained recommendations published by professional societies or health care institutions. The quality of clinical practice guidelines was assessed using the Appraisal of Guidelines Research and Evaluation II (AGREE II) tool. A descriptive synthesis of results was performed.FINDINGS Of 5530 citations screened, 41 full-text documents were included in the systematic review. Fifteen clinical practice guidelines were identified. AGREE II domain scores varied substantially. Identified...