Sources of complementary information are connected when we link user accounts belonging to the same user across different platforms or devices. The expanded information promotes the development of a wide range of applications, such as cross-platform prediction, cross-platform recommendation, and advertisement. Due to the significance of user account linkage and the widespread popularization of GPS-enabled mobile devices, there are increasing research studies on linking user account with spatio-temporal data across location-aware social networks. Being different from most existing studies in this domain that only focus on the effectiveness, we propose a novel framework entitled HFUL (A Hybrid Framework for User Account Linkage across Location-Aware Social Networks), where efficiency, effectiveness, scalability, robustness, and application of user account linkage are considered. Specifically, to improve the efficiency, we develop a comprehensive index structure from the spatio-temporal perspective, and design novel pruning strategies to reduce the search