Abnormal Accumulation of Vanadium in Patients on Chronic Hemodialysis Therapy

Tsukamoto, Yusuke; Saka, Satoshi; Kumano, Kazuo; Iwanami, Shigeru; Ishida, Osamu; Marumo, Fumiaki

doi:10.1159/000186177

Cited by 26 publications

(10 citation statements)

References 11 publications

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“…Considering that vana date is 90% protein-bound, the compound is probably not dialyzable to a significant degree. In preliminary studies we have shown that in patients on hemodialysis detectable amounts of vanadate were found in the dialysate at 1,2 and 4 h as compared to 0 time [94], These observations require further study as some investigators have shown a decrease in serum vanadate after dialysis [95]. One explanation for these results could be due to difference in the vanadate content of the dialysate as the concentration of this element correlates with levels found in tap water.…”

Section: Vanadate and Uremiamentioning

confidence: 99%

“…Also, serum values are probably not reflective of the levels as most of the element is inside the cells. Worldwide fluctuations of water vanadate levels have been noted [7,95]. The study of Tsukamoto et al [95] clearly showed that while serum vanadate was as much as 140 times greater in the end-stage renal disease patient as compared to healthy subjects, it was highly variable throughout Japan.…”

Section: Vanadate and Uremiamentioning

confidence: 99%

“…Worldwide fluctuations of water vanadate levels have been noted [7,95]. The study of Tsukamoto et al [95] clearly showed that while serum vanadate was as much as 140 times greater in the end-stage renal disease patient as compared to healthy subjects, it was highly variable throughout Japan. It was best correlated with tap water vanadate levels in the area where the dialysis center was located.…”

Section: Vanadate and Uremiamentioning

confidence: 99%

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Biochemistry and Pathophysiology of Vanadium

Dafnis

Sabatini²

1994

Nephron

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Section: Vanadate and Uremiamentioning

confidence: 99%

Section: Vanadate and Uremiamentioning

confidence: 99%

Section: Vanadate and Uremiamentioning

confidence: 99%

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Biochemistry and Pathophysiology of Vanadium

Dafnis

Sabatini²

1994

Nephron

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“…Urea, hydro gen ion, potassium, guanidino compounds [1], vanadium [2] are a few examples. High plasma concentrations of urea, albeit not im mediately fatal, cause vomiting, malaise, and platelet dysfunction [3,4], It therefore ap pears reasonable to call urea a uremic toxin.…”

Section: Small Uremic Toxinsmentioning

confidence: 99%

Quantitation of Dialysis

Cheung

1994

Blood Purif

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Despite the availability of calcitriol and recombinant erythropoietin to replace two major endocrine functions of the kidneys, mortality in chronic hemodialysis patients remains substantially higher than that in the general population. This suggests that most, if not all, patients are underdialyzed. While increasing small solute clearance by dialysis using urea kinetics as a guide improves clinical outcome, ‘adequate’ treatment using current techniques is only an arbitrary definition, since solute removal by dialysis remains far inferior to that of the normal native kidneys. In recent years, significant advances have been made in the structural and functional characterization of toxic uremic solutes that are in the higher molecular size range (‘middle molecules’). Several lines of evidence suggest that, in addition to small solutes, removal of middle molecules is also advantageous. The potential beneficial effects of synthetic high flux hemodialysis membranes are probably attributed to both their solute clearance profiles as well as their biocompatibility characteristics.

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“…4 On the other hand, the excess intake of vanadium inhibits biosynthesis of blood cholesterol and enzyme activities, and some diseases are induced because vanadium can be accumulated in blood. [5][6][7] Therefore, the level of vanadium in drinking water must be strictly controlled. A maximum concentration for vanadium in drinking water is fixed in some countries.…”

Section: Introductionmentioning

confidence: 99%

Flow Injection Analysis for Oxidation State Speciation of Vanadium(IV) and Vanadium(V) in Natural Water

2008

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A sensitive and simultaneous spectrophotometric flow injection method for the determination of vanadium(IV) and vanadium(V) is proposed. The method is based on the effect of ligands such as 2,4,6-tris(2-pyridyl)-1,3,5-triazine (TPTZ) and diphosphate on the conditional redox potential of iron(III)/iron(II) system. A four-channel flow system is assembled. In this flow system, diluted hydrochloric acid (1.0 × 10 -2 mol dm -3 ) as a carrier for standard/sample, acetate buffer (pH 5.5) as a carrier for diphosphate solution, an equimolar mixed solution of iron(III) and iron(II) and a TPTZ solution are delivered, so that the baseline absorbance can be established by forming a constant amount of iron(II)-TPTZ complex (λmax = 593 nm). Vanadium(IV) and/or vanadium(V) (400 μL) and diphosphate (200 μL) solutions are simultaneously introduced into the flow system; in this system the diphosphate solution passes through a delay coil. The potential of the iron(III)/iron(II) system increases in the presence of TPTZ, and therefore vanadium(IV) is easily oxidized by iron(III) to vanadium(V) to produce an iron(II)-TPTZ complex (a positive peak for vanadium(IV) appears). On the other hand, the potential of the redox system decreases in the presence of diphosphate, so that vanadium(V) can be easily reduced by iron(II) to vanadium(IV). In this case, the amount of iron(II) decreases according to the amount of vanadium(V). As a result, the produced iron(II)-TPTZ complex decreases (a negative peak for vanadium(V) appears). In this manner, two peaks for vanadium(IV) and vanadium(V) can be alternately obtained. The limits of detection (S/N = 3) are 1.98 × 10 -7 and 2.97 × 10 -7 mol dm -3 for vanadium(IV) and vanadium(V), respectivery. The method is applied to the simultaneous determination of vanadium(IV) and vanadium(V) in commercial bottled mineral water samples.

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Abnormal Accumulation of Vanadium in Patients on Chronic Hemodialysis Therapy

Cited by 26 publications

References 11 publications

Biochemistry and Pathophysiology of Vanadium

Biochemistry and Pathophysiology of Vanadium

Quantitation of Dialysis

Flow Injection Analysis for Oxidation State Speciation of Vanadium(IV) and Vanadium(V) in Natural Water

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