Abnormal afferent nerve endings in the soft palatal mucosa of sleep apnoics and habitual snorers

Friberg, Danielle; Gazelius, Bertil; Hökfelt, Tomas; Nordlander, Britt

doi:10.1016/s0167-0115(97)01016-1

Cited by 132 publications

(79 citation statements)

References 33 publications

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“…In agreement with this phenomenon, an interesting finding of the present study was that the OSAS patients with greater longest snoring time, average snoring episode duration, and relative snoring time on polysomnography tended to have impaired sensation of the soft palate. This finding was also consistent with previous studies [6,7,[15][16][17]. In spite of the conception that the subocclusive stage in snoring precedes the development of OSA [21], there was a broad spectrum ranging from mild to severe snorers among OSAS subjects.…”

Section: Discussionsupporting

confidence: 93%

Assessment of change in palatal sensation in obstructive sleep apnea patients by using two-point palatal discrimination

Choi

Kim

2017

Sleep Medicine

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Section: Discussionsupporting

confidence: 93%

Assessment of change in palatal sensation in obstructive sleep apnea patients by using two-point palatal discrimination

Choi

Kim

2017

Sleep Medicine

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“…Consistent with the above data, studies on the innervation of the palate-pharyngeal region in OSAS patients have revealed both increased and decreased number of nerves in the mucosa and muscles [8,13,38,39], as well as degenerative changes in myelinated and unmyelinated nerve fibers [40], and the degree of sensory neuropathy in UA correlates with the degree of OSAS (Figure 2) [41].…”

Section: Nerve Changes In Osassupporting

confidence: 72%

Nerve and Muscle Changes in the Upper Airways of Subjects with Obstructive Sleep Apnea: Structural Basis for the Neurogenic Theory

Cobo¹,

Macías²,

Alvarez³

et al. 2017

Sleep Apnea - Recent Updates

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Obstructive sleep apnea syndrome (OSAS) is a widely diffused disease associated with specific genetics, age, gender, craniofacial and upper airways anatomy, obesity, and endocrine conditions, but not with ethnicity profiles. The so-called neurogenic neurogenic theory of OSAS postulates that the collapse of the upper airways that characterize this disease is due to peripheral nerve degeneration that leads to muscle atrophy and collapse. This review attempts to summarize the structural and functional changes in both the sensory and motor innervation of the walls of the upper air ways in patients suffering from OSAS.

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“…There is morphologic evidence to support the presence of a sensory neuropathy in the UA in obstructive sleepdisordered breathing [16][17][18] .…”

Section: Discussionmentioning

confidence: 98%

Oropharyngeal examination as a predictor of obstructive sleep apnea: pilot study of gag reflex and palatal reflex

Valbuza

Oliveira

Conti

et al. 2011

Arq. Neuro-Psiquiatr.

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Obstructive sleep apnea (OSA) has high prevalence and may cause serious comorbities. The aim of this trial was to show if simple noninvasive methods such as gag reflex and palatal reflex are prospective multivariate assessments of predictor variables for OSA. Method: We evaluate gag reflex and palatal reflex, of fifty-five adult patients, and their subsequent overnight polysomnography. Results: Forty-one participants presented obstructive sleep apnea. The most relevant findings in our study were: [1] absence of gag reflex on patients with severe obstructive apnea (p=0.001); [2] absence of palatal reflex on moderate obstructive apnea patients (p=0.02). Conclusion: Gag reflex and palatal reflex, a simple noninvasive test regularly performed in a systematic neurological examination can disclose the impact of the local neurogenic injury associated to snoring and/or obstructive sleep apnea syndrome. Key words: obstructive sleep apnea, OSA, gag reflex, palatal reflex.Avaliação orofaríngea como preditor da apneia obstrutiva do sono: estudo piloto dos reflexos nauseoso e palatal RESUMO A síndrome da apneia obstrutiva do sono (SAOS) possui alta prevalência e pode causar sérias comorbidades. O objetivo deste estudo foi mostrar se métodos não invasivos como os reflexos nauseoso e palatal podem ser avaliações prospectivas multivariadas preditoras para SAOS. Método: Avaliamos os reflexos palatal e nauseoso em 55 pacientes adultos, com exame polissonográfico subsequente. Resultados: 41 pacientes apresentaram SAOS. Os achados mais relevantes em nosso estudo foram: [1] ausência do reflexo nauseoso em pacientes com SAOS grave (p=0,001); [2] ausência do reflexo palatal em pacientes com SAOS moderada (p=0,02). Conclusão: Os reflexos nauseoso e palatal, um simples exame não invasivo, aplicado em uma avaliação neurológica rotineira, pode revelar o impacto de lesões neurogênicas locais associadas ao ronco e/ou a SAOS. Palavras-Chave: apneia obstrutiva do sono, SAOS, reflexo palatal, reflexo nauseoso.

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Abnormal afferent nerve endings in the soft palatal mucosa of sleep apnoics and habitual snorers

Cited by 132 publications

References 33 publications

Assessment of change in palatal sensation in obstructive sleep apnea patients by using two-point palatal discrimination

Assessment of change in palatal sensation in obstructive sleep apnea patients by using two-point palatal discrimination

Nerve and Muscle Changes in the Upper Airways of Subjects with Obstructive Sleep Apnea: Structural Basis for the Neurogenic Theory

Oropharyngeal examination as a predictor of obstructive sleep apnea: pilot study of gag reflex and palatal reflex

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