Abnormal Ambulatory Blood Pressure and Early Renal Dysfunction in Sickle Cell Disease

Dubey, Shiv Ram Krishna; Shrivastava, Neha; Sharma, Tanya; Bhatt, Girish Chandra; Dhingra, Bhavna; Pakhare, Abhijit; Goel, Sudhir K.; Joshi, Deepti

doi:10.1007/s12098-020-03558-8

Cited by 4 publications

(7 citation statements)

References 26 publications

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“…Sickle cell disease (SCD) is associated with increased risk of cardiovascular disease, although office BP levels have been reported to be normal. On the contrary, masked hypertension has been consistently reported in prospective cohorts of children with SCD that underwent ABPM with prevalence ranging from 6 to 35% among studies [ 44 – 47 ]. In a cohort of 52 children with SCD, masked hypertension was found in 35% of the patiens [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

“…The second type of studies from which we can estimate the prevalence of MH in healthy children is studies on different diseases with healthy controls. Recently, Dubey et al and Yel et al showed that MH was not present in any of 26 and 20 healthy controls [ 21 , 44 ]. In another study, on obese children, Lurbe et al could find MH only in 1.1% of healthy controls [ 63 ].…”

Section: Introductionmentioning

confidence: 99%

“… Healthy children without any risk factor for hypertension [ 21 , 44 , 63 ]. Children with CKD and systolic OBP < 20th percentile [ 91 •].…”

Section: Introductionmentioning

confidence: 99%

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Masked Hypertension in Healthy Children and Adolescents: Who Should Be Screened?

Seeman,

Šuláková,

Stabouli

2023

Curr Hypertens Rep

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Purpose of Review The goal is to review masked hypertension (MH) as a relatively new phenomenon when patients have normal office BP but elevated out-of-office BP. Firstly, it was described in children in 2004. It has received increased attention in the past decade. Recent Findings The prevalence of MH in different pediatric populations differs widely between 0 and 60% based on the population studied, definition of MH, or method of out-of-office BP measurement. The highest prevalence of MH has been demonstrated in children with chronic kidney disease (CKD), obesity, diabetes, and after heart transplantation. In healthy children but with risk factors for hypertension such as prematurity, overweight/obesity, diabetes, chronic kidney disease, or positive family history of hypertension, the prevalence of MH is 9%. In healthy children without risk factors for hypertension, the prevalence of MH is very low ranging 0–3%. Summary In healthy children, only patients with the following clinical conditions should be screened for MH: high-normal/elevated office BP, positive family history of hypertension, and those referred for suspected hypertension who have normal office BP in the secondary/tertiary center.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Masked Hypertension in Healthy Children and Adolescents: Who Should Be Screened?

Seeman,

Šuláková,

Stabouli

2023

Curr Hypertens Rep

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“…260 Notably, relative systemic hypertension in sickle cell disease patients is linked to heightened susceptibility to pulmonary hypertension and renal dysfunction. 261,262 Increased hemolysis, increased arginase activity, and reduced arginineornithine ratios with attendant reduced nitric oxide bioavailability lead to increased vasoconstriction and higher blood pressures. 263…”

Section: Sickle Cell Anemiamentioning

confidence: 99%

InSH Consensus Guideline for the Management of Hypertension, 2023

Gupta,

Maheshwari,

Verma

et al. 2023

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“…In this issue of the Journal, Dubey et al examined renal function and 24-h blood pressure in 30 children with SCD in comparison to matched healthy controls [3]. Compared to the latter, patients with SCD had significantly higher prevalence of hypertension, proteinuria, and glomerular hyperfiltration.…”

mentioning

confidence: 99%