Abnormal amplitude of low frequency fluctuation and functional connectivity in non-neuropsychiatric systemic lupus erythematosus: a resting-state fMRI study

Yu, Hong; Qiu, Xiang Dan; Zhang, Yuqing; Deng, Yan; He, Maoyuan; Zhao, Yu-Ting; Zhai, Zhao-Hua

doi:10.1007/s00234-018-2138-6

Cited by 22 publications

(11 citation statements)

References 38 publications

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“…Consistent with our findings, previous studies found abnormal brain activity in MOG in non-NPSLE patients. Yu et al 15 found increased functional connectivity between left MOG and the left precuneus in non-NPSLE patients. Nystedt et al 35 found decreased connectivity between MOG and the left insula in non-NPSLE patients.…”

Section: Discussionmentioning

confidence: 98%

“… 49 Previous studies found abnormalities in the middle frontal gyrus in SLE patients which were consistent with our findings. Yu et al 15 found increased functional connectivity between the right MFG and left precuneus in non-NPSLE patients. Bonacchi et al 50 used an independent component analysis approach, and found decreased functional connectivity in the right middle frontal gyrus in NPSLE and non-NPSLE patients.…”

Section: Discussionmentioning

confidence: 98%

“… 13 Liu et al 14 found abnormal ReHo in the parahippocampal gyrus, fusiform gyrus, and thalamus in non-NPSLE patients and ReHo values in the left postcentral gyrus were negatively correlated with anxiety depression symptoms. Yu et al 15 found decreased ALFF in the precuneus and increased ALFF in the right cuneus and right calcarine fissure surrounding cortex in non-NPSLE patients. Zhang et al 16 found alteration of ALFF and functional connectivity density coupling strengths in the left superior parietal gyrus and bilateral precuneus in non-NPSLE patients.…”

Section: Introductionmentioning

confidence: 96%

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Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease

Chen¹,

Sun²,

Wang³

et al. 2021

NDT

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Purpose In this study, we seek to investigate dynamic changes of brain activity in non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) patients with inactive disease. Patients and Methods Thirty-one non-NPSLE patients with inactive disease and 20 matched healthy controls underwent the blood oxygenation level-dependent fMRI examination. Dynamic regional homogeneity (ReHo) and fractional amplitude of low-frequency ﬂuctuations (fALFF) were used to analyze the brain activity in typical band (0.01–0.08 Hz), slow-4 (0.027–0.073 Hz) and slow-5 (0.01–0.027 Hz). Pearson’s correlation analysis was performed to correlate dynamic regional homogeneity (dReHo) and dynamic fractional amplitude of low-frequency ﬂuctuations (dfALFF) values for clusters of voxels where significant group differences were found with clinical variables in non-NPSLE patients with inactive disease. Results In typical band, non-NPSLE patients showed increased dReHo in left middle occipital gyrus (MOG) compared to healthy controls. Meanwhile, patients showed decreased dfALFF in right superior frontal gyrus (SFG) and bilateral middle frontal gyrus (MFG) in typical band. In slow-4, increased dReHo in left MOG was found in non-NPSLE patients. In slow-5, non-NPSLE patients showed increased dReHo in left MOG, left calcarine fissure and surrounding cortex, right precentral gyrus (PreCG) and left postcentral gyrus (PoCG). Meanwhile, non-NPSLE patients showed decreased dfALFF in left SFG, right MFG, and right PreCG in slow-5. Moreover, the glucocorticoid dose showed significantly negative correlations with dReHo values in right PreCG in slow-5, left PoCG in slow-5, and left MOG in typical band. Conclusion dReHo and dfALFF abnormalities in different frequency bands may be the key characteristics in the pathogenesis mechanism of non-NPSLE.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 96%

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Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease

Chen¹,

Sun²,

Wang³

et al. 2021

NDT

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“…Next, the images were smoothed with a 4 mm full width at half maximum (FWHM) Gaussian kernel to reduce noise. After that, linear detrending and bandpass filtering (from 0.01 to 0.08 Hz) were performed to reduce the influence of low-frequency drifts and high-frequency physiological noise [24]. Finally, the white matter signal, the cerebrospinal fluid signal, the global signal, and Friston 24 head motions were removed as nuisance covariates.…”

Section: Amplitude Of Low-frequency Fluctuation Preprocessing and Anamentioning

confidence: 99%

Altered intrinsic brain activity and regional cerebral blood flow in patients with chronic neck and shoulder pain

2020

Pol J Radiol

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Purpose: To identify the changes of intrinsic brain activity and regional cerebral blood flow in patients with chronic neck and shoulder pain (CNSP) by using amplitude of low-frequency fluctuation (ALFF) analysis and arterial spin labelling study. Material and methods: In total, 28 CNSP patients and 25 age-matched and sex-matched healthy controls (HCs) participated in the study. Resting-state functional magnetic resonance imaging (rs-fMRI) and arterial spin labelling (ASL) MRI were acquired. Correlations between ALFF and cerebral blood flow (CBF) were analysed. Subsequently, the differences in ALFF and CBF were compared in the two groups. Finally, the visual analogue scale (VAS) was also assessed in the CNSP group. Results: Compared with HCs, CNSP patients showed significantly abnormal ALFF and CBF in several brain regions, including the cerebellum posterior lobe, middle orbitofrontal gyrus, medial superior frontal gyrus, middle temporal gyrus, precuneus, cingulate gyrus, middle occipital gyrus, middle frontal gyrus, postcentral gyrus, precentral gyrus, and superior parietal gyrus. Correlation analysis showed that the ALFF value of the medial superior frontal gyrus positively correlated with the VAS score. However, no correlation was found between the CBF values and the VAS score. Conclusions: The altered ALFF and CBF values in CNSP patients were observed in different pain-related brain regions that were involved in pain modulation and perception. The combination of rs-fMRI and ASL MRI might provide complementary information for increasing our understanding of the neuropathology in CNSP.

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“…2 To date, there have been several studies that demonstrated the impaired brain functional alterations in SLE patients without obvious neuropsychiatric syndromes (known as non-NPSLE). [3][4][5][6] However, the dysfunction is still the most diagnostic challenging and gray area of the ACR classification, 7 and its pathogenesis is unknown. At present, the widely accepted hypothesis 8 is that cytokines from blood trigger the destruction of the blood-brain barrier (BBB), which makes autoantibodies enter the central nervous system (CNS).…”

Section: Introductionmentioning

confidence: 99%

Alterations of spontaneous brain activity in systematic lupus erythematosus patients without neuropsychiatric symptoms: A resting-functional MRI study

Piao

Wang

Qin

et al. 2021

Lupus

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Purpose To explore the alterations of spontaneous neuronal activity using amplitude of low-frequency fluctuation (ALFF), fractional amplitude of low-frequency fluctuation (fALFF), and regional homogeneity (ReHo) in non-NPSLE patients and their relationship with the anxiety and depression statuses. Methods Twenty-three non-NPSLE patients and 28 healthy controls were enrolled in this study. Resting-state functional magnetic resonance imaging was firstly analyzed by ALFF, fALFF, and ReHo. The relationships between ALFF/fALFF/ReHo values of abnormal regions and anxiety/depression rating scales, including Self-Rating Anxiety (SAS) and Self-Rating Depression (SDS), were also analyzed. Results Compared with HC, non-NPSLE had decreased ALFF values in the bilateral postcentral gyrus, while increased ALFF values in the bilateral inferior temporal gyrus, left putamen, and bilateral precuneus. Non-NPSLE showed reduced fALFF values in the left lingual gyrus, left middle occipital gyrus, right postcentral gyrus, and left superior parietal gyrus, while increased fALFF values were in the left inferior temporal gyrus, right hippocampus, bilateral precuneus, and bilateral superior frontal gyrus. Reduced ReHo values were in the bilateral postcentral gyrus and higher ReHo values were in the left inferior temporal gyrus, left putamen, and bilateral superior frontal gyrus. In the non-NPSLE group, the mean ALFF values of bilateral precuneus were positively correlated with the SAS rating scales (R = 0.5519, p = 0.0176); either were the mean ALFF values of right inferior temporal gyrus and SAS rating scales (R = 0.5380, p = 0.0213). The mean fALFF values of left inferior temporal gyrus were positively correlated with SAS rating scales (R = 0.5700, p = 0.0135). And the mean ReHo values of left putamen were positively correlated with SDS (R = 0.5477, p = 0.0186). Conclusion Non-NPSLE exhibited abnormal spontaneous neural activity and coherence in several brain regions mainly associated with cognitive and emotional functions. The ALFF values of bilateral PCUN, the right ITG, the fALFF values of left ITG, and the ReHo values of left PUT may be complementary biomarkers for assessing the psychiatric symptoms.

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Abnormal amplitude of low frequency fluctuation and functional connectivity in non-neuropsychiatric systemic lupus erythematosus: a resting-state fMRI study

Cited by 22 publications

References 38 publications

Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease

Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease

Altered intrinsic brain activity and regional cerebral blood flow in patients with chronic neck and shoulder pain

Alterations of spontaneous brain activity in systematic lupus erythematosus patients without neuropsychiatric symptoms: A resting-functional MRI study

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