Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome

Källstrand, Johan; Olssón, Olle; Nehlstedt, Sara Fristedt; Sköld, Mia Ling; Nielzén, Sören

doi:10.2147/ndt.s10593

Cited by 19 publications

(12 citation statements)

References 63 publications

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“…In fact, these changes in wave V have a positive predictive value of 78% and a negative predictive value of 73% for wave V. These differences in subjects with ASD can be further illustrated with masking experiments. Such paradigms revealed abnormal interpeak latencies between waves I-V and III-V (Thivierge et al, 1990 ), the reduced amplitude of wave III (Källstrand et al, 2010 ), and asymmetric masking by contralateral noise (Khalfa et al, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Mansour

Burchell

Kulesza

2021

Front. Integr. Neurosci.

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behaviors, poor social skills, and difficulties with communication. Beyond these core signs and symptoms, the majority of subjects with ASD have some degree of auditory and vestibular dysfunction. Dysfunction in these sensory modalities is significant as normal cognitive development depends on an accurate representation of our environment. The hearing difficulties in ASD range from deafness to hypersensitivity and subjects with ASD have abnormal sound-evoked brainstem reflexes and brainstem auditory evoked potentials. Vestibular dysfunction in ASD includes postural instability, gait dysfunction, and impaired gaze. Untreated vestibular dysfunction in children can lead to delayed milestones such as sitting and walking and poor motor coordination later in life. Histopathological studies have revealed that subjects with ASD have significantly fewer neurons in the auditory hindbrain and surviving neurons are smaller and dysmorphic. These findings are consistent with auditory dysfunction. Further, the cerebellum was one of the first brain structures implicated in ASD and studies have revealed loss of Purkinje cells and the presence of ectopic neurons. Together, these studies suggest that normal auditory and vestibular function play major roles in the development of language and social abilities, and dysfunction in these systems may contribute to the core symptoms of ASD. Further, auditory and vestibular dysfunction in children may be overlooked or attributed to other neurodevelopmental disorders. Herein we review the literature on auditory and vestibular dysfunction in ASD. Based on these results we developed a brainstem model of central auditory and vestibular dysfunction in ASD and propose that simple, non-invasive but quantitative testing of hearing and vestibular function be added to newborn screening protocols.

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Section: Introductionmentioning

confidence: 99%

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Mansour

Burchell

Kulesza

2021

Front. Integr. Neurosci.

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“…The differences of functional measures of the brainstem such as ABR indicate some form of abnormality. A common ABR abnormality is in the peak III amplitude and/or latency (Tanguay et al, 1982;Källstrand et al, 2010;Magliaro et al, 2010;Dabbous, 2012;Ververi et al, 2015;Claesdotter-Knutsson et al, 2019) which is suggested to be an indicator of SOC (Moller, 2006) activity. Additionally, ABR abnormalities are also seen in animal models such as Fmr1 KO mice (Rotschafer et al, 2015), α7-nAChR KO mice (Felix et al, 2019), Cntnap2 KO rats (Scott et al, 2018) and PA (Strata et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Amplitudes are not commonly examined, and results are inconsistent. A group found peak III amplitude to be lower for ASD when a forward masking condition was applied (Figure 2B; Källstrand et al, 2010) while two others found it to be higher (Ververi et al, 2015;Claesdotter-Knutsson et al, 2019). Another study found that the ASD group had higher correlation between right and left ears compared to the typically developing participants (Claesdotter-Knutsson et al, 2019) which could be related to difficulties in the processing of everyday sounds.…”

Section: Functional Studiesmentioning

confidence: 91%

“…The results of ABR are less consistent in terms of how the waves of autistic individuals are different than control but the general trend indicates some form of abnormality (Tanguay et al, 1982;Maziade et al, 2000;Rosenhall et al, 2003;Tas et al, 2007;Russo et al, 2008Russo et al, , 2009Källstrand et al, 2010;Magliaro et al, 2010;Azouz et al, 2014;El Shennawy et al, 2014;Wegiel et al, 2014;Ververi et al, 2015;Miron et al, 2016Miron et al, , 2021Chen et al, 2019;Claesdotter-Knutsson et al, 2019;Ramezani et al, 2019;Jones et al, 2020;Kamita et al, 2020;Li et al, 2020).…”

Section: Functional Studiesmentioning

confidence: 92%

“…The delay in ABR peaks is also found in other animal models (Strata et al, 2005;Scott et al, 2018) and in autistic individuals (Tanguay et al, 1982;Maziade et al, 2000;Rosenhall et al, 2003;Russo et al, 2008;Magliaro et al, 2010;Azouz et al, 2014;Ververi et al, 2015). Moreover, forward masking and gap detection are impaired in KO (Felix et al, 2019), reflecting the forward masking impairment observed in autistic individuals (Källstrand et al, 2010).…”

Section: Ube3a Modelmentioning

confidence: 92%

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Tonotopic alterations in inhibitory input to the medial nucleus of the trapezoid body in a mouse model of Fragile X syndrome

McCullagh

Salcedo

Huntsman

et al. 2017

J of Comparative Neurology

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Hyperexcitability and the imbalance of excitation/inhibition are one of the leading causes of abnormal sensory processing in Fragile X syndrome (FXS). The precise timing and distribution of excitation and inhibition is crucial for auditory processing at the level of the auditory brainstem, which is responsible for sound localization ability. Sound localization is one of the sensory abilities disrupted by loss of the Fragile X Mental Retardation 1 (Fmr1) gene. Using triple immunofluorescence staining we tested whether there were alterations in the number and size of presynaptic structures for the three primary neurotransmitters (glutamate, glycine and GABA) in the auditory brainstem of Fmr1 knockout mice. We found decreases in either glycinergic or GABAergic inhibition to the medial nucleus of the trapezoid body (MNTB) specific to the tonotopic location within the nucleus. MNTB is one of the primary inhibitory nuclei in the auditory brainstem and participates in the sound localization process with fast and well-timed inhibition. Thus, a decrease in inhibitory afferents to MNTB neurons should lead to greater inhibitory output to the projections from this nucleus. In contrast, we did not see any other significant alterations in balance of excitation/inhibition in any of the other auditory brainstem nuclei measured, suggesting that the alterations observed in the MNTB are both nucleus and frequency specific. We furthermore show that glycinergic inhibition may be an important contributor to imbalances in excitation and inhibition in FXS and that the auditory brainstem is a useful circuit for testing these imbalances.

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Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome

Cited by 19 publications

References 63 publications

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Table_2.docx

Tonotopic alterations in inhibitory input to the medial nucleus of the trapezoid body in a mouse model of Fragile X syndrome

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