Abnormal binding of indocyanine green with serum proteins in a patient with delayed ICG clearance

Kawasaki, Hironaka; Oda, Hiroshi; Sakaguchi, Seigo; Tominaga, K.; Hirayama, Chisato

doi:10.1016/0009-8981(73)90056-9

Cited by 14 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

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“…The PA image exhibits an increase in intensity at the peak wavelength for each contrast agent, i.e., 710 and 780 nm for IcG and 890 nm for L-JA and IcG-JA. Unlike IcG, which is known to have different optical properties depending on concentration and solvent medium, [73,74] the spectral profile of IcG-JA and L-JA remained unaffected by changes in concentration and solvent. Incubation in PBS, FBS, and cell culture media at 4 and 37 °C shows that L-JA also has superior storage stability when compared to IcG (Figure S2, Supporting Information).…”

Section: Particle Characterizationmentioning

confidence: 93%

“…[85] Due to high uptake by plasma proteins like lipoproteins and albumin, IcG is cleared rapidly and safely in the liver as bile. [74,86] Encapsulation within a properly pegylated liposome slows this well-characterized IcG clearance pathway. These liposomes are shielded from macrophage uptake and experience much slower rates of proteolysis and opsonization.…”

Section: Contrast Enhancement and Circulation In Vivomentioning

confidence: 99%

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A Facile Approach to Producing Liposomal J‐Aggregates of Indocyanine Green with Diagnostic and Therapeutic Potential

Stern,

Shrestha,

Porter

2024

Advanced Therapeutics

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Liposomal J‐Aggregates of Indocyanine Green (L‐JA) can serve as a biocompatible and biodegradable nanoparticle for photoacoustic imaging (PAI) and photothermal therapy (PTT). When compared to monomeric indocyanine green (IcG), L‐JA is characterized by longer circulation, improved photostability, elevated absorption at longer wavelengths, and increased photoacoustic signal generation. However, the documented methods for the production of L‐JA vary widely. An approach to efficiently form IcG J‐aggregates (IcG‐JA) directly in liposomes at elevated temperatures is developed. Aggregating within fully formed liposomes ensures particle uniformity and allows for control of J‐aggregate size. L‐JA has unique properties compared to IcG. L‐JA provides significant contrast enhancement in photoacoustic images for up to 24 h after injection, while IcG and unencapsulated IcG‐JA are cleared within an hour. L‐JA allows for more accurate photoacoustic‐based blood oxygen saturation (sO2) estimation and particle tracking compared to IcG. Furthermore, photothermal heating of L‐JA with an 852 nm laser is demonstrated to be more effective at lower laser powers than conventional 808 nm lasers for the first time. The presented technique offers an avenue for formulating a multi‐faceted contrast agent for photoacoustic imaging and photothermal therapy that offers significant advantages over other conventional agents.

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Section: Particle Characterizationmentioning

confidence: 93%

Section: Contrast Enhancement and Circulation In Vivomentioning

confidence: 99%

A Facile Approach to Producing Liposomal J‐Aggregates of Indocyanine Green with Diagnostic and Therapeutic Potential

Stern,

Shrestha,

Porter

2024

Advanced Therapeutics

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show abstract

“…710 nm and 780 nm for IcG and 890 nm for L-JA and IcG-JA. Unlike IcG, which is known to have different optical properties depending on concentration and solvent medium, 41,42 the spectral profile of IcG-JA and L-JA remained unaffected by change in concentration and solvent.…”

mentioning

confidence: 93%

Rapid production of liposome encapsulated J-aggregates of indocyanine green

Stern,

Shrestha,

Porter

2024

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV

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Liposomal J-Aggregates of Indocyanine Green (L-JA) offer significant advantages over conventionally used monomeric indocyanine green (IcG) for photoacoustic imaging. When compared to IcG, which is often hindered by low circulation time and poor photostability, L-JA are characterized by longer circulation times, vastly improved photostability, elevated absorption at longer wavelengths, and increased photoacoustic signal generation. However, the documented methods for production of L-JA varies widely, which can lead to significant batch variability. We developed an approach to form IcG J-aggregates (IcG-JA) directly in liposomes efficiently and reproducibly at elevated temperatures. Aggregating within fully formed liposomes ensures particle uniformity and allows for the control of J-Aggregate size within the final particle. This technique provides a more robust and facile approach to producing these viable agents.

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Hepatic Drug Clearance in Children: Studies with Indocyanine Green as a Model Substrate

Evans

Relling

Graaf

et al. 1989

Journal of Pharmaceutical Sciences

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Abnormal binding of indocyanine green with serum proteins in a patient with delayed ICG clearance

Cited by 14 publications

References 12 publications

A Facile Approach to Producing Liposomal J‐Aggregates of Indocyanine Green with Diagnostic and Therapeutic Potential

A Facile Approach to Producing Liposomal J‐Aggregates of Indocyanine Green with Diagnostic and Therapeutic Potential

Rapid production of liposome encapsulated J-aggregates of indocyanine green

Hepatic Drug Clearance in Children: Studies with Indocyanine Green as a Model Substrate

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