Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study

Wengler, Kenneth; Ha, Jason; Syritsyna, Olga; Bangiyev, Lev; Coyle, Patricia K.; Duong, Timothy Q.; Schweitzer, Mark E.; He, Xiang

doi:10.1016/j.mri.2020.04.017

Cited by 18 publications

(22 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Noncontrast MRI techniques based on diffusion‐weighted (DWI) and arterial spin labeling (ASL) MRI have been used to map whole‐brain P w S and E w (water extraction fraction, related to k po ) in relapsing‐remitting MS 51 . Consistent with the findings in the present study, decreased P w S was observed in chronic (non‐GBCA‐enhancing) MS lesions.…”

Section: Discussionsupporting

confidence: 86%

“…Although NAWM k po differences between groups did not reach statistical significance, studies with a larger cohort and whole‐brain SS‐DCE‐MRI may reveal significant differences in NAWM. Decreased P w S has been reported in NAWM in a small cohort of relapsing‐remitting MS ( n = 11) subjects compared to HC ( n = 14) 51 . Slight NAWM PMS k po decreases and v b increases in PMS combine to produce P w S values that are not different from HC at the group level in this study.…”

Section: Discussionsupporting

confidence: 42%

“…Decreased P w S has been reported in NAWM in a small cohort of relapsing-remitting MS (n = 11) subjects compared to HC (n = 14). 51 [52][53][54][55][56][57] and thus the composite P w S measurement may be blind to important pathological k po changes.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Gray matter blood‐brain barrier water exchange dynamics are reduced in progressive multiple sclerosis

Tagge

Anderson

Springer

et al. 2021

Journal of Neuroimaging

View full text Add to dashboard Cite

Background and Purpose: To compare transcapillary wall water exchange, a putative marker of cerebral metabolic health, in brain T 2 white matter (WM) lesions and normal appearing white and gray matter (NAWM and NAGM, respectively) in individuals with progressive multiple sclerosis (PMS) and healthy controls (HC).Methods: Dynamic-contrast-enhanced 7T MRI data were obtained from 19 HC and 23 PMS participants. High-resolution pharmacokinetic parametric maps representing tissue microvascular and microstructural properties were created by shutter-speed (SS) paradigm modeling to obtain estimates of blood volume fraction (v b ), water molecule capillary efflux rate constant (k po ), and the water capillary wall permeability surface area product (P w S ≡ v b *k po ). Linear regression models were used to investigate differences in (i) k po and P w S between groups in NAWM and NAGM, and (ii) between WM lesions and NAWM in PMS.Results: High-resolution parametric maps were produced to visualize tissue classes and resolve individual WM lesions. Normal-appearing gray matter k po and P w S were significantly decreased in PMS compared to HC (p ≤ .01). Twenty-one T 2 WM lesions were analyzed in 10 participants with PMS. k po was significantly decreased in WM lesions compared to PMS NAWM (p < .0001). Conclusions:Transcapillary water exchange is reduced in PMS NAGM compared to HC and is further reduced in PMS WM lesions, suggesting pathologically impaired brain metabolism. k po provides a sensitive measure of cerebral metabolic activity and/or coupling, and can be mapped at higher spatial resolution than conventional imaging techniques assessing metabolic activity.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 42%

See 1 more Smart Citation

Gray matter blood‐brain barrier water exchange dynamics are reduced in progressive multiple sclerosis

Tagge

Anderson

Springer

et al. 2021

Journal of Neuroimaging

View full text Add to dashboard Cite

show abstract

“…Altered BBB permeability has been reported in many diseases, such as stroke, Alzheimer's disease, and multiple sclerosis. 16,18,19,22,25,35 Although it has been postulated that in SCD, endothelia are prone to damage, 1,11,36,37 there were few studies investigating BBB permeability in SCD. This is largely attributed to a scarcity of non-invasive techniques to measure BBB permeability, especially those suitable for use in pediatric patients.…”

Section: Discussionmentioning

confidence: 99%

“…A number of non-invasive MRI techniques have been developed to measure the BBB permeability to water molecules, by labeling the water spins arterially and measuring water exchange across the BBB. [16][17][18][19][20][21][22][23] Water extraction with phase-contrast arterial spin tagging (WEPCAST) MRI is one of these arterial spin labeling (ASL) based techniques which can quantify BBB permeability to water without using any contrast agent. 17 It selectively measures the ASL signal at venous side at a long post-labeling delay (PLD) (3500 msec used in young adults and 4000 msec used in older adults) and gives quantification of water extraction.…”

mentioning

confidence: 99%

Imaging Blood–Brain Barrier Permeability Through MRI in Pediatric Sickle Cell Disease: A Feasibility Study

Lin

Lance

McIntyre

et al. 2021

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background Blood–brain barrier (BBB) disruption may lead to endothelium dysfunction and inflammation in sickle cell disease (SCD). However, abnormalities of BBB in SCD, especially in pediatric patients for whom contrast agent administration less than optimal, have not been fully characterized. Purpose To examine BBB permeability to water in a group of pediatric SCD participants using a non‐invasive magnetic resonance imaging technique. We hypothesized that SCD participants will have increased BBB permeability. Study Type Prospective cross‐sectional. Population Twenty‐six pediatric participants (10 ± 1 years, 15F/11M) were enrolled, including 21 SCD participants and 5 sickle cell trait (SCT) participants, who were siblings of SCD patients. Field Strength/Sequence 3 T. Water extraction with phase‐contrast arterial spin tagging with echo‐planer imaging, phase‐contrast and T1‐weighted magnetization‐prepared rapid acquisition of gradient echo. Assessment Water extraction fraction (E), BBB permeability‐surface area product (PS), cerebral blood flow, hematological measures (hemoglobin, hematocrit, hemoglobin S), neuropsychological scores (including domains of intellectual ability, attention and executive function, academic achievement and adaptive function, and a composite score). Regions of interest were drawn by Z.L. (6 years of experience). Statistical Tests Wilcoxon rank sum test and chi‐square test for group comparison of demographics. Multiple linear regression analysis of PS with diagnostic category (SCD or SCT), hematological measures, and neuropsychological scores. A two‐tailed P value of 0.05 or less was considered statistically significant. Results Compared with SCT participants, SCD participants had a significantly higher BBB permeability to water (SCD: 207.0 ± 33.3 mL/100 g/minute, SCT: 171.2 ± 27.2 mL/100 g/minute). SCD participants with typically more severe phenotypes also had a significantly leakier BBB than those with typically milder phenotypes (severe: 217.3 ± 31.7 mL/100 g/minute, mild: 193.3 ± 31.8 mL/100 g/minute). Furthermore, more severe BBB disruption was associated with worse hematological symptoms, including lower hemoglobin concentrations (β = −8.84, 95% confidence interval [CI] [−14.69, −3.00]), lower hematocrits (β = −2.96, 95% CI [−4.84, −1.08]), and higher hemoglobin S fraction (β = 0.77, 95% CI [0.014, 1.53]). Data Conclusion These findings support a potential role for BBB dysfunction in SCD pathogenesis of ischemic injury. Level of Evidence 2 Technical Efficacy Stage 2

show abstract

Water exchange across the blood–brain barrier and epilepsy: Review on pathophysiology and neuroimaging

Abdennadher,

Jacobellis,

Václavů

et al. 2024

Epilepsia Open

View full text Add to dashboard Cite

The blood–brain barrier (BBB) is a barrier protecting the brain and a milieu of continuous exchanges between blood and brain. There is emerging evidence that the BBB plays a major role in epileptogenesis and drug‐resistant epilepsy, through several mechanisms, such as water homeostasis dysregulation, overexpression of drug transporters, and inflammation. Studies have shown abnormal water homeostasis in epileptic tissue and altered aquaporin‐4 water channel expression in animal epilepsy models. This review focuses on abnormal water exchange in epilepsy and describes recent non‐invasive MRI methods of quantifying water exchange.Plain Language SummaryAbnormal exchange between blood and brain contribute to seizures and epilepsy. The authors describe why correct water balance is necessary for healthy brain functioning and how it is impacted in epilepsy. This review also presents recent MRI methods to measure water exchange in human brain. These measures would improve our understanding of factors leading to seizures.

show abstract

Abnormal blood-brain barrier water exchange in chronic multiple sclerosis lesions: A preliminary study

Cited by 18 publications

References 46 publications

Gray matter blood‐brain barrier water exchange dynamics are reduced in progressive multiple sclerosis

Gray matter blood‐brain barrier water exchange dynamics are reduced in progressive multiple sclerosis

Imaging Blood–Brain Barrier Permeability Through MRI in Pediatric Sickle Cell Disease: A Feasibility Study

Water exchange across the blood–brain barrier and epilepsy: Review on pathophysiology and neuroimaging

Contact Info

Product

Resources

About