2015
DOI: 10.1007/s00223-015-0025-2
|View full text |Cite
|
Sign up to set email alerts
|

Abnormal Bone Mechanical and Structural Properties in Adolescent Idiopathic Scoliosis: A Study with Finite Element Analysis and Structural Model Index

Abstract: Previous studies found adolescent idiopathic scoliosis (AIS) is associated with low bone mineral density (BMD) and abnormal bone quality, whilst the association between AIS and their bone strength is unknown. From high-resolution peripheral quantitative computed tomography-generated images, bone mechanical properties can be evaluated with finite element analysis (FEA), and trabecular rod-plate configuration related to trabecular bone strength can be quantified by structure model index (SMI). This study aimed t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
29
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 31 publications
(31 citation statements)
references
References 38 publications
2
29
0
Order By: Relevance
“…Further experimental study showed that trabecular plate-related parameters were highly correlated to elastic moduli and yield strength, while trabecular rod-related parameters were only slightly correlated to the mechanical properties21. In the present study, conventional homogenous FE analysis provided consistent result as previous study with HR-pQCT image obtained at distal radius34. More precise experimental setting with consideration of mineralization related tissue specific modules and heterogeneous FE analysis also resulted in similar finding.…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…Further experimental study showed that trabecular plate-related parameters were highly correlated to elastic moduli and yield strength, while trabecular rod-related parameters were only slightly correlated to the mechanical properties21. In the present study, conventional homogenous FE analysis provided consistent result as previous study with HR-pQCT image obtained at distal radius34. More precise experimental setting with consideration of mineralization related tissue specific modules and heterogeneous FE analysis also resulted in similar finding.…”
Section: Discussionsupporting
confidence: 87%
“…These observations have led researchers to investigate the roles of low bone mass and bone metabolism in the etiopathogenesis of AIS. More recent HR-pQCT studies revealed lower trabecular number6 and reduced computational determined apparent modulus in AIS34. It is speculated that such systemic abnormal bone quality and lower bone mineralization would make the AIS spine more vulnerable to deform once there is a certain degree of apical rotation of disproportionate or asymmetric skeletal growth1.…”
Section: Discussionmentioning
confidence: 99%
“…TV, BV, BV/TV and BMD of TV and BV were assessed. Endpoint mechanical properties (week 8) in stiffness, apparent modulus and failure load were estimated by µFEA (FE-software version 1.13, Scanco Medical) by the axial compression test in the z-direction with the material modulus defined at 10 GPa using the default evaluation program, as previously reported (Cheuk et al, 2015).…”
Section: D Bone Morphometry and µFeamentioning
confidence: 99%
“…Since vertebral body at spine mainly consists of trabecular bone, it is questionable how well bone morphometry parameters (e.g., trabecular area, cortical area) at distal radius were correlated with bone morphometry at spine. Nevertheless, recent studies showed abnormal bone parameters in AIS manifested by lower cortical and trabecular thickness, lower cortical and trabecular vBMD and more rod-like trabeculae at the distal radius131427. Wang et al 28.…”
Section: Discussionmentioning
confidence: 99%