Abnormal bowel movement frequency increases the risk of rectal cancer: evidence from cohort studies with one million people

Shen, Lin; Li, Chao; Li, Na; Shen, Liangfang; Li, Zhanzhan

doi:10.1042/bsr20200355

“…According to the analysis, positive family history of CRC, sedentary behavior of more than six hours per day, bowel movements more than once per day, and low educational level were found to be independent predictors of CRC (P = 0.014, P = 0.003, P = 0.036, and P = 0.008, respectively). A person with a positive family history of CRC was 8. included more than one million participants provided strong evidence supporting the association between the frequency of bowel movement and CRC risk [27] . Moreover, a cohort study found that the frequency of bowel movements was associated with an increased risk of rectal cancer but not CRC, and constipation was associated with decreased risks of both CRC and rectal cancer [28] .…”

Section: Independent Predictors Of Crcmentioning

confidence: 85%

Risk Factors for Colorectal Cancer: A Case-control Study in Egypt, 2022

Flifel,

Elshaer,

Abdelhai

et al. 2023

ARCADEs of MEDICINE

0

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Background:In the literature, it has been pointed out that lifestyle and environmental factors might contribute substantially to the etiology of colorectal cancer (CRC). Identifying modifiable risk factors would be crucial for prevention. This study was conducted to determine the risk factors for CRC. Patients and Methods: A case-control study was conducted at the Maadi Armed Forces Medical Complex in Egypt in 2022, including 101 cases and 101 controls. All participants underwent face-to-face interviews with a structured questionnaire to gather information about sociodemographic characteristics, lifestyle, dietary and gastrointestinal habits, family, medical, and reproductive history, and occupational data. Regression analysis was done to model CRC as a function of the potential risk factors. Results: In univariate analysis, CRC was significantly associated with positive family history for CRC, not attaining higher education, not having a spouse, infrequent fruit and vegetable consumption, frequent consumption of processed meat, sedentary behavior, and bowel movements more than once per day. According to the multivariate regression analysis, four independent predictors of CRC were identified, namely: positive family history of CRC [OR = 8.70, 95% CI = 1.60,48.8], sedentary behavior more than 6 hours per day [OR = 3.54, 95% CI = 1.60,8.1], bowel movements more than once per day [OR = 2.07, 95% CI = 1.1,4.1], and not attaining higher education [OR = 2.47, 95% CI = 1.3,4.8]. Conclusion:The study highlighted predictors of CRC. Awareness campaigns and screening of high-risk groups are recommended. Moreover, longitudinal multicentric studies with objective evaluations of physical activity and dietary consumption are required.

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“…Studies on the association between bowel frequency and CRC risk have not yielded consistent results [ 87 - 90 ]. In a previous meta-analysis of ten cohort studies worldwide, increased frequency of bowel movements was only linked to an increased risk of rectal cancer [ 91 ]. The results were inconsistent among included studies, where a follow-up study in the Chinese population showed that those who had more than one bowel movement per day had an increased risk of CRC within five years of follow-up, while three studies in the USA and one in Japan did not show an association between bowel frequency and CRC risk [ 91 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a previous meta-analysis of ten cohort studies worldwide, increased frequency of bowel movements was only linked to an increased risk of rectal cancer [ 91 ]. The results were inconsistent among included studies, where a follow-up study in the Chinese population showed that those who had more than one bowel movement per day had an increased risk of CRC within five years of follow-up, while three studies in the USA and one in Japan did not show an association between bowel frequency and CRC risk [ 91 ]. Our meta-analysis included two case-control studies and one cohort study, all of which reported a significant positive association between high bowel frequency (more than once per day) and an increased CRC risk among the Chinese population.…”

Section: Discussionmentioning

confidence: 99%

National and subnational incidence, mortality and associated factors of colorectal cancer in China: A systematic analysis and modelling study

Xu,

Zhao,

Li

et al. 2023

J Glob Health

8

0

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Background Due to their known variation by geography and economic development, we aimed to evaluate the incidence and mortality of colorectal cancer (CRC) in China over the past decades and identify factors associated with CRC among the Chinese population to provide targeted information on disease prevention. Methods We conducted a systemic review and meta-analysis of epidemiolocal studies on the incidence, mortality, and associated factors of CRC among the Chinese population, extracting and synthesising data from eligible studies retrieved from seven global and Chinese databases. We pooled age-standardised incidence rates (ASIRs) and mortality rates (ASMRs) for each province, subregion, and the whole of China, and applied a joinpoint regression model and annual per cent changes (APCs) to estimate the trends of CRC incidence and mortality. We conducted random-effects meta-analyses to assess the effect estimates of identified associated risk factors. Results We included 493 articles; 271 provided data on CRC incidence or mortality, and 222 on associated risk factors. Overall, the ASIR of CRC in China increased from 2.75 to 19.39 (per 100 000 person-years) between 1972 and 2019 with a slowed-down growth rate (APC 1 = 5.75, APC 2 = 0.42), while the ASMR of CRC decreased from 12.00 to 7.95 (per 100 000 person-years) between 1974 and 2020 with a slight downward trend (APC = -0.89). We analysed 62 risk factors with synthesized data; 16 belonging to the categories of anthropometrics factors, lifestyle factors, dietary factors, personal histories and mental health conditions were graded to be associated with CRC risk among the Chinese population in the meta-analysis limited to the high-quality studies. Conclusions We found substantial variation of CRC burden across regions and provinces of China and identified several associated risk factors for CRC, which could help to guide the formulation of targeted disease prevention and control strategies. Registration PROSPERO: CRD42022346558.

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“…In the process, we found that most of the eQTL were significantly associated with CRC, so we excluded the associated CRC traits to be able to effectively identify other phenotypes associated with them. Several best eQTL-related phenotypes were discovered to be strongly linked or comorbid with the risk of CRC, including bowel movement, alcohol consumption, C-C motif chemokine 22, family history of primary malignant neoplasm, cholelithiasis, and helicobacter pylori infection (Table S5) [14,[37][38][39][40].…”

Section: Summary Data-based Mendelian Randomizationmentioning

confidence: 99%

Genome-Wide Association and Transcriptome-Wide Association Studies Identify Novel Susceptibility Genes Contributing to Colorectal Cancer

Yin

¹

,

Song

²

,

Wang

³

et al. 2022

Journal of Immunology Research

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Background. Colorectal cancer (CRC) is among the most common cancers diagnosed worldwide. Although genome-wide association studies have effectively identified the genetic basis of CRC, there is still unexplained variability in genetic risk. Transcriptome-wide association studies (TWAS) integrate summary statistics from CRC genome-wide association studies (GWAS) with gene expression data to prioritize these GWAS findings and uncover additional gene-trait correlations. Methods. First, we carried out a post-GWAS analysis using summary statistics from a large-scale GWAS of CRC ( n = 4,562 cases, n = 382,756 controls). Second, combined with the expression weight sets from GTEx (v7), susceptibility genes were identified with the FUSION software. Colocalization, conditional and fine-mapping analyses, phenome-wide association study (pheWAS), and Mendelian randomization were employed to further characterize the observed correlations. Results. In the post-GWAS analyses, we first identified new genome-wide significant associations: three genomic risk loci were identified at 8q24.21 (rs6983267, P = 6.98 × 10 − 12 ), 15q13.3 (rs58658771, P = 1.40 × 10 − 10 ), and 18q21.1 (rs6507874, P = 1.91 × 10 − 14 ). In addition, the TWAS also identified four loci statistically significantly associated with CRC risk, largely explained by expression regulation, including six candidate genes (DUSP10, POU5F1B, C11orf53, COLCA1, COLCA2, and GREM1-AS1). We further discovered evidence that low expression of COLCA2 is correlated with CRC risk with Mendelian randomization. Conclusions. We discovered novel CRC risk loci and candidate functional genes by merging gene expression and GWAS summary data, offering new insight into the molecular processes underlying CRC development. This makes it easier to prioritize potential genes for follow-up functional research in CRC.

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Abnormal bowel movement frequency increases the risk of rectal cancer: evidence from cohort studies with one million people

Cited by 8 publications

References 32 publications

Risk Factors for Colorectal Cancer: A Case-control Study in Egypt, 2022

Risk Factors for Colorectal Cancer: A Case-control Study in Egypt, 2022

National and subnational incidence, mortality and associated factors of colorectal cancer in China: A systematic analysis and modelling study

Genome-Wide Association and Transcriptome-Wide Association Studies Identify Novel Susceptibility Genes Contributing to Colorectal Cancer

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