2012
DOI: 10.1007/s12311-012-0418-y
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Abnormal Cerebellar Structure Is Dependent on Phenotype of Isolated Cleft of the Lip and/or Palate

Abstract: Isolated cleft lip and/or palate (ICLP) is one of the most common congenital birth defects in the USA, affecting roughly 1 in 600 births annually. Along with the facial deformity, this population has been found to have abnormal neurodevelopment and gross structural abnormalities in the brain, particularly within the cerebellum. The current study examined cerebellar structure within the two primary subtypes of ICLP: cleft lip with/without cleft palate (CL/P) and cleft palate alone (CPO). A large sample of 107 s… Show more

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Cited by 20 publications
(15 citation statements)
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“…Based on our prior work, the pattern of brain abnormalities is not identical across all cleft types [van der Plaas et al, 2010; DeVolder et al, 2013]. In particular, individuals with cleft palate only show a different pattern in which the cerebellum is not reduced in volume but instead shows a different distribution of cerebellar tissue [DeVolder et al, 2013].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Based on our prior work, the pattern of brain abnormalities is not identical across all cleft types [van der Plaas et al, 2010; DeVolder et al, 2013]. In particular, individuals with cleft palate only show a different pattern in which the cerebellum is not reduced in volume but instead shows a different distribution of cerebellar tissue [DeVolder et al, 2013].…”
Section: Discussionmentioning
confidence: 99%
“…In particular, individuals with cleft palate only show a different pattern in which the cerebellum is not reduced in volume but instead shows a different distribution of cerebellar tissue [DeVolder et al, 2013]. This is especially interesting when considering that variation in IRF6 is associated with an increased risk for cleft lip only or combined cleft lip and palate and not with an increased risk of cleft palate only [Rahimov et al, 2008].…”
Section: Discussionmentioning
confidence: 99%
“…These differences are gross (enlarged anterior cortex and smaller cerebellum) and regional (comparatively smaller temporal lobes and reduced occipital white matter) (Nopoulos, Langbehn, Canady, Magnotta, & Richman, 2007; Nopoulos, Berg, Canady, et al, 2002). Differences have been identified in infancy (Yang, McPherson, Shu, Xie, & Xiang, 2011), childhood (Devolder, Richman, Conrad, Magnotta, & Nopoulos, 2013; Nopoulos et al, 2007), and adulthood (Nopoulos, Berg, Canady, et al, 2002). Additionally, these differences have been found to directly correlate with disruptions in cognitive functioning (Nopoulos, Berg, VanDemark, et al, 2002), behavior (van der Plas, Koscik, Conrad, Moser, & Nopoulos, 2013), and speech (Conrad et al, 2010).…”
Section: Reading Developmentmentioning
confidence: 99%
“…Embora a literatura tradicional tenda a dar ao comportamento, à aprendizagem e às características neuropsicológicas uma explicação ambiental (11) , estudos mais recentes têm demonstrado, por meio de imagens do cérebro, maior relação biológica, baseada em diferenças neuronais e diretas na neuromaturação em crianças com fissura labiopalatina (12)(13)(14) .…”
Section: Introductionunclassified
“…Estudos recentes realizados na área de Psicologia, com a investigação neuropsicológica de crianças com fissura labiopalatina na idade escolar (6)(7)(8)(9)12,13) , têm demonstrado prejuízos em diversas funções corticais, dentre elas, as relacionadas à atenção, percepção, linguagem e memória, com repercussão consistente no aprendizado escolar. A criança no ensino fundamental vivencia exigências para a aprendizagem e necessita do desenvolvimento de habilidades cognitivas mais efetivas.…”
Section: Introductionunclassified