Abnormal composition and function of high‐density lipoproteins in atopic dermatitis patients

Trieb, Markus; Wolf, Peter; Knuplez, Eva; Weger, Wolfgang; Schuster, Christian; Peinhaupt, Miriam; Holzer, Michael; Trakaki, Athina; Eichmann, Thomas O.; Lass, Achim; Wadsack, Christian; Schuligoi, Rufina; Heinemann, Ákos; Marsche, Gunther

doi:10.1111/all.13620

Cited by 25 publications

(30 citation statements)

References 9 publications

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“…To investigate the molecular mechanisms potentially involved in higher oxidative stress, we evaluated PON activities and levels of MPO in AD subjects. A decrease in PON1 arylesterase in HDL isolated from serum adult patients affected by AD was previously demonstrated by Trieb et al [ 40 ]. We also observed a decrease in paraoxonase and lactonase activities in serum of AD children.…”

Section: Discussionmentioning

confidence: 59%

“…The significant increase in the MPO/PON1 (paraoxonase) ratio supports alterations of HDL in AD patients. Other authors demonstrated HDL alterations in AD patients with modifications of HDL lipid and apoprotein composition linked to the formation of dysfunctional HDL and alterations of the interactions of HDL–eosinophils [ 40 , 41 ]. Our findings agree with previous evidence in chronic pediatric dermatitis conditions describing lipid profile alterations [ 42 , 43 ] and a proinflammatory HDL particle with reduced PON1 activity [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Oxidative Stress and Alterations of Paraoxonases in Atopic Dermatitis

Simonetti

Bacchetti

Ferretti³

et al. 2021

Antioxidants

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Background: previous studies reported the involvement of reactive oxygen species (ROS) and lipid peroxidation in the pathogenesis of inflammatory skin diseases. The aim of our study was to investigate the relationship between oxidative stress and inflammation in children affected by atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. Methods: levels of lipid hydroperoxides, total antioxidant capacity, and activities of the enzymes myeloperoxidase (MPO), PON1, and PON2/3 were investigated in 56 atopic pediatric patients, and compared with 48 sex-/age-matched healthy controls. Results: significantly higher levels of lipid hydroperoxides and lower values of total antioxidant potential were observed in the serum of AD children compared to that of the controls. Significant lower PON1 activities, and a significant increase in levels of MPO were observed in serum of patients, with a higher serum MPO level/PON1 paraoxonase activity ratio in patients compared to that in the controls. Significantly lower lactonase activity of PON enzymes was observed in polymorphonuclear cells isolated from AD patients. Statistically negative correlation was established between the activity of intracellular PON2/3 activity and ROS levels. Conclusions: our data confirmed that AD is associated with higher oxidative damage and a decrease in antioxidant defense. Moreover, alterations of extracellular and intracellular PON activity can promote lipoprotein dysfunction in AD patients.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Alterations of Paraoxonases in Atopic Dermatitis

Simonetti

Bacchetti

Ferretti³

et al. 2021

Antioxidants

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“…Therefore, phospholipids, which compose the surface lipid monolayer of HDL are an important determinant of its ability to accept cholesterol [ 53 ]. Moreover, both, the phospholipid content [ 53 , 54 ] and lysophospholipid content of HDL [ 55 , 56 , 57 , 58 ] markedly affect its anti-inflammatory properties. Sphingosine-1-phosphate (S1P) plays an important role in maintaining vascular homeostasis, which will be discussed in more detail in 7.2.…”

Section: Hdl Compositionmentioning

confidence: 99%

Fetal High-Density Lipoproteins: Current Knowledge on Particle Metabolism, Composition and Function in Health and Disease

2021

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Cholesterol and other lipids carried by lipoproteins play an indispensable role in fetal development. Recent evidence suggests that maternally derived high-density lipoprotein (HDL) differs from fetal HDL with respect to its proteome, size, and function. Compared to the HDL of adults, fetal HDL is the major carrier of cholesterol and has a unique composition that implies other physiological functions. Fetal HDL is enriched in apolipoprotein E, which binds with high affinity to the low-density lipoprotein receptor. Thus, it appears that a primary function of fetal HDL is the transport of cholesterol to tissues as is accomplished by low-density lipoproteins in adults. The fetal HDL-associated bioactive sphingolipid sphingosine-1-phosphate shows strong vasoprotective effects at the fetoplacental vasculature. Moreover, lipoprotein-associated phospholipase A2 carried by fetal-HDL exerts anti-oxidative and athero-protective functions on the fetoplacental endothelium. Notably, the mass and activity of HDL-associated paraoxonase 1 are about 5-fold lower in the fetus, accompanied by an attenuation of anti-oxidative activity of fetal HDL. Cholesteryl ester transfer protein activity is reduced in fetal circulation despite similar amounts of the enzyme in maternal and fetal serum. This review summarizes the current knowledge on fetal HDL as a potential vasoprotective lipoprotein during fetal development. We also provide an overview of whether and how the protective functionalities of HDL are impaired in pregnancy-related syndromes such as pre-eclampsia or gestational diabetes mellitus.

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“…It should be noted that recombinant apoC-III appears to act in an anti-allergic manner. For example, apoC-III reduces the activation of eosinophils, which play a key role in allergies [108,109].…”

Section: Ckd-induced Changes In the Hdl Proteomementioning

confidence: 99%

Current Understanding of the Relationship of HDL Composition, Structure and Function to Their Cardioprotective Properties in Chronic Kidney Disease

et al. 2020

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In the general population, the ability of high-density lipoproteins (HDLs) to promote cholesterol efflux is a predictor of cardiovascular events, independently of HDL cholesterol levels. Although patients with chronic kidney disease (CKD) have a high burden of cardiovascular morbidity and mortality, neither serum levels of HDL cholesterol, nor cholesterol efflux capacity associate with cardiovascular events. Important for the following discussion on the role of HDL in CKD is the notion that traditional atherosclerotic cardiovascular risk factors only partially account for this increased incidence of cardiovascular disease in CKD. As a potential explanation, across the spectrum of cardiovascular disease, the relative contribution of atherosclerotic cardiovascular disease becomes less important with advanced CKD. Impaired renal function directly affects the metabolism, composition and functionality of HDL particles. HDLs themselves are a heterogeneous population of particles with distinct sizes and protein composition, all of them affecting the functionality of HDL. Therefore, a more specific approach investigating the functional and compositional features of HDL subclasses might be a valuable strategy to decipher the potential link between HDL, cardiovascular disease and CKD. This review summarizes the current understanding of the relationship of HDL composition, metabolism and function to their cardio-protective properties in CKD, with a focus on CKD-induced changes in the HDL proteome and reverse cholesterol transport capacity. We also will highlight the gaps in the current knowledge regarding important aspects of HDL biology.

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Abnormal composition and function of high‐density lipoproteins in atopic dermatitis patients

Cited by 25 publications

References 9 publications

Oxidative Stress and Alterations of Paraoxonases in Atopic Dermatitis

Oxidative Stress and Alterations of Paraoxonases in Atopic Dermatitis

Fetal High-Density Lipoproteins: Current Knowledge on Particle Metabolism, Composition and Function in Health and Disease

Current Understanding of the Relationship of HDL Composition, Structure and Function to Their Cardioprotective Properties in Chronic Kidney Disease

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