Abnormal cutaneous vasomotion and reduced cutaneous blood mass remain in congestive heart failure even with normalized cardiovascular hemodynamics

Seino, Yoshihiko; Tsukamoto, Hiroshi; Ohki, Kiyoshi; Nakamura, Tatsuo; Kashiwagi, Mutsumi; Takano, Teruo; Hayakawa, Hirokazu

doi:10.1016/0002-8703(93)90703-c

Cited by 12 publications

(5 citation statements)

References 15 publications

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“…26,27 In this study, we show significant impairment of cutaneous response to acetylcholine in SAs with HF. Indeed, we show, for the first time to our knowledge, that SAs with HF had significant impairment of microvascular endothelial function compared with other ethnic groups, and ethnicity was still associated with microvascular endothelial dysfunction, even after adjustment for age, presence of hypertension and diabetes, blood pressure, and glucose levels.…”

Section: Discussionsupporting

confidence: 55%

Ethnic Differences in Macrovascular and Microvascular Function in Systolic Heart Failure

Shantsila

Wrigley

Shantsila

et al. 2011

Circ: Heart Failure

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Background— Endothelial dysfunction is implicated in the pathophysiological features of heart failure (HF), and ethnic differences in the presentation of cardiovascular disease are evident, with an excess seen among South Asians (SAs). However, data on ethnic differences in endothelial function in HF are limited. Methods and Results— In a cross-sectional study, we recruited 128 subjects with systolic HF: 50 SAs, 50 whites, and 28 African Caribbeans (ACs). In addition, SAs with systolic HF were compared with 40 SAs with coronary artery disease without HF (“disease controls”) and 40 SA healthy controls. Macrovascular endothelial function was assessed by measurement of flow-mediated dilation (FMD) in response to hyperemia, arterial stiffness was assessed by the pulse-wave velocity, and microvascular endothelial function was assessed by forearm laser Doppler flowmetry. CD144-expressing endothelial microparticles were measured by flow cytometry. When compared with disease controls and healthy controls, SAs with HF had an impaired microvascular response to acetylcholine ( P =0.001) and reduced FMD ( P <0.001). In comparing ethnic groups, SAs with HF had an impaired response to acetylcholine (123±95.5%) compared with whites (258±156%) and ACs (286±173%, P <0.001 for both). Whites had a higher FMD (8.49±4.63%) than SAs (4.76±4.78%, P <0.001) and ACs (4.55±3.56%, P =0.01). No difference in endothelial-independent response was observed between study groups or in pulse-wave velocity. Ethnicity remained associated with microvascular endothelial function even after adjustment for age, presence of hypertension and diabetes mellitus, blood pressure, and glucose levels ( P =0.003). There were no differences in numbers of endothelial microparticles. Conclusions— The SAs with HF have impaired microvascular and macrovascular endothelial function but preserved arterial elastic properties. Significant ethnic differences in endothelial function are evident in subjects with HF, with ethnicity being associated with microvascular endothelial dysfunction in this disorder.

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Section: Discussionsupporting

confidence: 55%

Ethnic Differences in Macrovascular and Microvascular Function in Systolic Heart Failure

Shantsila

Wrigley

Shantsila

et al. 2011

Circ: Heart Failure

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“…It may be a simple conse quence of severely depressed left ventricular output and subsequently reduced finger cutaneous blood flow. How ever, using laser technology, Seino et al [19] demon strated that in CHF with normalized cardiovascular he modynamics, finger cutaneous blood flow and mass re mained significantly reduced. This could reflect a de creased vis a tergo or concomitantly an increase in postcapillarv resistance accounting for a decreased CBV.…”

Section: Discussionmentioning

confidence: 99%

Impaired Microcirculation in Heart Failure

et al. 1996

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The aim of the present study was to examine the nailfold capillary morphology and dynamics in treated chronic heart failure (CHF) in relation to parameters of left ventricular structure and function. Twenty patients with CHF class II according to the New York Heart Association underwent a capillaroscopic examination at the finger nailfold using a computerized videophotometric system (Capiflow®) at rest and after 1 min arterial occlusion. Study parameters ere number, length and diameter of the capillaries as well as capillary blood velocity (CBV). Further experiments included echocardiography and determination of left ventricular ejection fraction by Tc scintigraphy. Nailfold capillaries in established CHF are enlarged and the CBV is dramatically decreased. The reactive hyperemic response to 1 min arterial occlusion is attenuated. CBV correlates positively with left ventricular ejection fraction (r = 0.61, p = 0.01) and inversely with left ventricular end-diastolic (r = -0.56, p = 0.04) and end-systolic (r = -0.69, p = 0.01) diameters. The time-to-peak flow after 1 min arterial occlusion is positively related (r = 0.68, p < 0.05) to the duration of CHF. Our data indicate that finger microcirculation in CHF deteriorates as a function of the severity and duration of heart failure.

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“…It was already shown that patients with coronary heart disease demonstrate changes in cutaneous microcirculation and a decrease in cutaneous blood mass [3,[8][9][10][11]. One of the suggested predictors of risk for cardiovascular disease is Endothelial Function which is based on sensitivity to long-acting nitrates and vasoactive drugs.…”

Section: Introductionmentioning

confidence: 99%

Peripheral microcirculatory hemodynamic changes in patients with myocardial ischemia

Ovadia‐Blechman

Avrahami

Weizman-Shammai

et al. 2015

Biomedicine & Pharmacotherapy

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Abnormal cutaneous vasomotion and reduced cutaneous blood mass remain in congestive heart failure even with normalized cardiovascular hemodynamics

Cited by 12 publications

References 15 publications

Ethnic Differences in Macrovascular and Microvascular Function in Systolic Heart Failure

Ethnic Differences in Macrovascular and Microvascular Function in Systolic Heart Failure

Impaired Microcirculation in Heart Failure

Peripheral microcirculatory hemodynamic changes in patients with myocardial ischemia

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