Abnormal Degree Centrality in Children with Low-Function Autism Spectrum Disorders: A Sleeping-State Functional Magnetic Resonance Imaging Study

Xu, Shoujun; Li, Meng; Yang, Ce; Fang, Xiangling; Ye, Miaoting; Wu, Yi‐Long; Yang, Binrang; Huang, Wenxian; Peng, Li; Ma, Xiaofen; Fu, Shishun; Yin, Yi; Jian-guo, Tian; Gan, Yong; Jiang, Guihua

doi:10.2147/ndt.s367104

NDT

2022

DOI: 10.2147/ndt.s367104

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Abnormal Degree Centrality in Children with Low-Function Autism Spectrum Disorders: A Sleeping-State Functional Magnetic Resonance Imaging Study

Shoujun Xu¹,

Meng Li²,

Ce Yang³

et al.

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2024

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Cited by 2 publications

References 89 publications

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Gender and age related brain structural and functional alterations in children with autism spectrum disorder

Zhou,

Hua,

Tang

et al. 2024

Cerebral Cortex

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To explore the effects of age and gender on the brain in children with autism spectrum disorder using magnetic resonance imaging. 185 patients with autism spectrum disorder and 110 typically developing children were enrolled. In terms of gender, boys with autism spectrum disorder had increased gray matter volumes in the insula and superior frontal gyrus and decreased gray matter volumes in the inferior frontal gyrus and thalamus. The brain regions with functional alterations are mainly distributed in the cerebellum, anterior cingulate gyrus, postcentral gyrus, and putamen. Girls with autism spectrum disorder only had increased gray matter volumes in the right cuneus and showed higher amplitude of low-frequency fluctuation in the paracentral lobule, higher regional homogeneity and degree centrality in the calcarine fissure, and greater right frontoparietal network–default mode network connectivity. In terms of age, preschool-aged children with autism spectrum disorder exhibited hypo-connectivity between and within auditory network, somatomotor network, and visual network. School-aged children with autism spectrum disorder showed increased gray matter volumes in the rectus gyrus, superior temporal gyrus, insula, and suboccipital gyrus, as well as increased amplitude of low-frequency fluctuation and regional homogeneity in the calcarine fissure and precentral gyrus and decreased in the cerebellum and anterior cingulate gyrus. The hyper-connectivity between somatomotor network and left frontoparietal network and within visual network was found. It is essential to consider the impact of age and gender on the neurophysiological alterations in autism spectrum disorder children when analyzing changes in brain structure and function.

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Gender and age related brain structural and functional alterations in children with autism spectrum disorder

Zhou,

Hua,

Tang

et al. 2024

Cerebral Cortex

View full text Add to dashboard Cite

show abstract

Structure-function coupling in white matter uncovers the hypoconnectivity in autism spectrum disorder

Qing,

Zhang,

Liu

et al. 2024

Molecular Autism

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Abnormal Degree Centrality in Children with Low-Function Autism Spectrum Disorders: A Sleeping-State Functional Magnetic Resonance Imaging Study

Cited by 2 publications

References 89 publications

Gender and age related brain structural and functional alterations in children with autism spectrum disorder

Gender and age related brain structural and functional alterations in children with autism spectrum disorder

Structure-function coupling in white matter uncovers the hypoconnectivity in autism spectrum disorder

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