Abnormal Development of Kitten Retino-Geniculate Connectivity in the Absence of Action Potentials

Archer, Steven M.; Dubin, Mark W.; Stark, Louisa A.

doi:10.1126/science.7100921

Cited by 124 publications

(47 citation statements)

References 33 publications

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“…A role for neuronal activity in the development of the topographic projection in the retinotectal system had been proposed previously (Archer et al, 1982;O'Leary et al, 1986;Sretavan et al, 1988;Cook et al, 1999). However, results from experiments in which TTX was used to block neuronal activity in the visual system of developing zebrafish suggested no significant role for neuronal activity in the mapping process (Stuermer et al, 1990).…”

Section: Discussionmentioning

confidence: 57%

Analysis of the Activity-Deprived Zebrafish MutantmachoReveals an Essential Requirement of Neuronal Activity for the Development of a Fine-Grained Visuotopic Map

2001

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The formation of a retinotopic map is thought to involve an activity-independent molecular phase for early steps of both axon pathfinding and projection and a later phase in which cross talk between retinal ganglion cells (RGCs) and tectal neurons modifies and refines the neuronal connections. We report that the maturation of the retinotopic map in the zebrafish tectum involves activity-dependent processes. Zebrafish larvae mutant for the gene macho (mao) lack neuronal activity in RGCs and also display an enlarged retinotectal projection field but no significant increase in single axon length. This morphological defect can be phenocopied by raising larvae under TTX-induced neural impulse blockade. The effect of activity deprivation is dependent on the developmental stage. The projection phenotype in mao as well as in the TTX-treated larvae develops between 4 and 6 d post-fertilization (dpf), after complete tectal coverage is first achieved. Electrophysiological recordings of RGCs in wild-type and mao zebrafish larvae reveal a temporally regulated reduction of sodium current in the mutant between 5 and 6 dpf. This coincides with the time of the axonal projection shifting on the tectum to compensate for the disparate growth patterns of the retina and the tectum. Our genetic and physiological analyses suggest a model in which neuronal activity in RGCs is needed for the establishment of morphological plasticity.

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Section: Discussionmentioning

confidence: 57%

Analysis of the Activity-Deprived Zebrafish MutantmachoReveals an Essential Requirement of Neuronal Activity for the Development of a Fine-Grained Visuotopic Map

2001

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“…Thus, the CNS provides an appropriate environment within which specific connections can be made. Several mechanisms have been hypothesized to account for specificity of fiber growth as well as connectivity, such as neuronal activity (Archer et al, 1982;Dubin et al, 1986;Shatz and Stryker, 1988;Sretavan et al, 1988), cell surface molecules (Weiss, 1947;Edelman, 1984a,b), growth or chemotactic factors (Ramon y Cajal, 19 10, 1959;Levi-Montalcini, 1964), electrical fields (Jaffe and Nuccitelli, 1977;Robinson, 1985;Faber and Korn, 1989), and adjacent fibers (Lynch et al, 1972(Lynch et al, , 1976Rutishauser et al, 1978), among others. Through these postulated mechanisms, the brain regulates the development of correctly functioning circuits, which are essential for normal brain organization and function.…”

mentioning

confidence: 99%

Target and neurotransmitter specificity of fetal central nervous system transplants: importance for functional reinnervation

et al. 1994

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The ability of grafted fetal ventral mesencephalic dopaminergic (DAergic) neuroblasts to reinnervate the unilaterally DA denervated rat striatum and improve motoric asymmetry has been well documented in several laboratories. The importance of host target specificity, and catecholamine (CA) neurotransmitter species, in the ability of grafts to ameliorate rotational responses to apomorphine and to affect electrophysiological characteristics of striatal neurons has not been systematically studied. We unilaterally lesioned Sprague-Dawley rats with 6-hydroxydopamine (6-OHDA) and verified the lesions using apomorphine (0.05 mg/kg, s.c.)-induced rotational behavior. Some of the animals subsequently received, intrastriatally, either DA neuroblasts from ventral mesencephalon that normally innervate the striatum, or from arcuate nucleus that do not. Additionally, two other groups were included that received either a CAergic graft from the noradrenergic nucleus locus coeruleus or a graft of cerebral cortex, which normally projects to the striatum but does not contain CAergic neurons. Only the fetal ventral mesencephalic grafts were able to reduce apomorphine- induced rotations and normalize striatal cell firing rates; striatal cell firing rates with ventral mesencephalic grafts were 1.43 Hz +/- 0.22, with arcuate nucleus grafts were 6.03 +/- 0.73, with locus coeruleus grafts were 4.71 +/- 0.74, and with cerebral cortex grafts were 4.36 +/- 0.45. Moreover, only the ventral mesencephalic grafts produced a dense tyrosine hydroxylase (TH)-immunoreactive nerve terminal network in the striatum; in contrast, the arcuate nucleus grafts did not reinnervate the striatum. In locus coeruleus grafted striata, few very long TH-positive axons were seen. We thus conclude that target specificity and neurotransmitter type are critically important in the ability of a graft to functionally reinnervate the 6- OHDA denervated striatum.

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“…1987;Constantine-Paton et al 1990). Both types of neuronal plasticity are activity-dependent (Archer et al 1982;Constantine-Paton et al 1990;Bliss and Collingridge 1993); both are thought to require Hebbian association of pre-and postsynaptic activity (Malinow and Miller 1986;Collingridge and Bliss 1987;Gustafsson et al 1987;Fregnac et al 1988;Greuel et al 1988) and the activation of N-methyl-n-aspartate (NMDA) receptors (Cline et al 1987;Collingridge and Bliss 1987). Recently, LTP was linked to critical period plasticity in the primary somatosensory cortex (Crair and Malenka 1995) and the primary visual cortex (Kirkwood et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Deficiency in induction but not expression of LTP in hippocampal slices from young rats.

Liao¹,

Malinow²

1996

Learning & Memory

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In this study we examine developmental changes between postnatal day (PND) 4 and 14 in synaptic transmission and plasticity in the CA1 region of hippocampal slices. We confirm previous results that tetanus-induced long-term potentiation (LTP) in field recordings is diminished in slices from younger animals. LTP in whole-cell current-clamp recordings is also diminished in younger animals. However, robust LTP can be induced in young animals if sufficient postsynaptic depolarization is provided during LTP induction. Furthermore, we find differences in synaptic transmission between PND 4 and 14, suggesting that the depolarization during tetanic stimulation in young tissue is ineffective to produce LTP. These results indicate that the smaller potentiation in field recordings in slices from younger animals is attributable to insufficient postsynaptic depolarization during LTP induction rather than a defect in expression mechanisms.

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Abnormal Development of Kitten Retino-Geniculate Connectivity in the Absence of Action Potentials

Cited by 124 publications

References 33 publications

Analysis of the Activity-Deprived Zebrafish MutantmachoReveals an Essential Requirement of Neuronal Activity for the Development of a Fine-Grained Visuotopic Map

Analysis of the Activity-Deprived Zebrafish MutantmachoReveals an Essential Requirement of Neuronal Activity for the Development of a Fine-Grained Visuotopic Map

Target and neurotransmitter specificity of fetal central nervous system transplants: importance for functional reinnervation

Deficiency in induction but not expression of LTP in hippocampal slices from young rats.

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