Abnormal development of motor neurons in perfluorooctane sulphonate exposed zebrafish embryos

Zhang, Ling; Li, Yuanyuan; Tian, Chen; Xia, Wei; Zhou, Yifang; Wan, Yanjian; Lv, Ziquan; Li, Gengqi; Xu, Shunqing

doi:10.1007/s10646-011-0604-6

Cited by 35 publications

(19 citation statements)

References 42 publications

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“…Moreover, perfluorooctane sulfonic acid perturbs the functioning of motor neurones by altering α-Tubulin and proliferating cell nuclear antigen 56. It also induces brain oxidative stress by dysregulating cyclin-dependant kinase 5 and peroxiredoxin, and causes an inflammatory glial response 57.…”

Section: Discussionmentioning

confidence: 99%

Pop, heavy metal and the blues: secondary analysis of persistent organic pollutants (POP), heavy metals and depressive symptoms in the NHANES National Epidemiological Survey

et al. 2014

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ObjectivesPersistent environmental pollutants, including heavy metals and persistent organic pollutants (POPs), have a ubiquitous presence. Many of these pollutants affect neurobiological processes, either accidentally or by design. The aim of this study was to explore the associations between assayed measures of POPs and heavy metals and depressive symptoms. We hypothesised that higher levels of pollutants and metals would be associated with depressive symptoms.SettingNational Health and Nutrition Examination Survey (NHANES).ParticipantsA total of 15 140 eligible people were included across the three examined waves of NHANES.Primary and secondary outcome measuresDepressive symptoms were assessed using the nine-item version of the Patient Health Questionnaire (PHQ-9), using a cut-off point of 9/10 as likely depression cases. Organic pollutants and heavy metals, including cadmium, lead and mercury, as well as polyfluorinated compounds (PFCs), pesticides, phenols and phthalates, were measured in blood or urine.ResultsHigher cadmium was positively associated with depression (adjusted Prevalence Ratios (PR)=1.48, 95% CI 1.16 to 1.90). Higher levels of mercury were negatively associated with depression (adjusted PR=0.62, 95% CI 0.50 to 0.78), and mercury was associated with increased fish consumption (n=5500, r=0.366, p<0.001). In addition, several PFCs (perfluorooctanoic acid, perfluorohexane sulfonic acid, perfluorodecanoic acid and perfluorononanoic acid) were negatively associated with the prevalence of depression.ConclusionsCadmium was associated with an increased likelihood of depression. Contrary to hypotheses, many of persistent environmental pollutants were not associated or negatively associated with depression. While the inverse association between mercury and depressive symptoms may be explained by a protective role for fish consumption, the negative associations with other pollutants remains unclear. This exploratory study suggests the need for further investigation of the role of various agents and classes of agents in the pathophysiology of depression.

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Section: Discussionmentioning

confidence: 99%

Pop, heavy metal and the blues: secondary analysis of persistent organic pollutants (POP), heavy metals and depressive symptoms in the NHANES National Epidemiological Survey

et al. 2014

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“…Adult behavioral and cognitive disturbances were reported A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 17 after exposure of rodent pups to PFAAs, usually at high doses [241][242][243]. Abnormal motor neuron development and locomotion were seen in zebrafish larvae exposed to PFAAs [256,257]. Very little information is found about other PFASs than PFOA and PFOS, and other species, in particular wildlife.…”

Section: Animals Experience a Range Of Adverse Effects Usually At Himentioning

confidence: 99%

Per- and polyfluorinated substances (PFASs): Environmental challenges

Krafft

Riess²

2015

Current Opinion in Colloid & Interface Science

234

122

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“…Western blotting assay was conducted using approximately 300 larvae from each replicate (n ¼ 3) as described previously [28]. In total, 50 mg of each protein sample was loaded into each lane of a 12% sodium dodecyl sulfate-polyacrylamide gel, separated by electrophoresis, and then transferred to a polyvinylidene difluoride membrane.…”

Section: Western Blotting Assaymentioning

confidence: 99%

Acute exposure to DE‐71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae

Chen

Huang

et al. 2012

Enviro Toxic and Chemistry

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Abstract-The aim of the present study was to investigate the acute developmental neurotoxicity of polybrominated diphenyl ethers (PBDEs) in zebrafish larvae. From 2 to 120 h postfertilization zebrafish embryos were exposed to 31.0, 68.7, and 227.6 mg/L). The authors studied the locomotor behavior of larvae, involvement of the cholinergic system, and selected gene and protein expressions in the central nervous system. The results showed that low DE-71 concentration caused hyperactivity, whereas higher concentrations decreased activity during the dark period. During the light period, larval activity was significantly reduced in a concentration-dependent manner. In the cholinergic system, acetylcholinesterase activity significantly increased (10.7 and 12.4%) in the 68.7 and 227.6 mg/L exposure groups, respectively, and acetylcholine concentration accordingly decreased (60.5%) in the 227.6 mg/L exposure group. The mRNA expressions of genes encoding myelin basic protein, neuron microtubule protein (a1-tubulin), and sonic hedgehog a were significantly downregulated. Western blotting assay demonstrated that the protein concentration of a1-tubulin was also decreased.Overall, the present study demonstrated that acute exposure to PBDEs can disrupt the neurobehavior of zebrafish larvae and affect cholinergic neurotransmission and neuron development. Environ. Toxicol. Chem. 2012;31:233831: -234431: . # 2012

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Abnormal development of motor neurons in perfluorooctane sulphonate exposed zebrafish embryos

Cited by 35 publications

References 42 publications

Pop, heavy metal and the blues: secondary analysis of persistent organic pollutants (POP), heavy metals and depressive symptoms in the NHANES National Epidemiological Survey

Pop, heavy metal and the blues: secondary analysis of persistent organic pollutants (POP), heavy metals and depressive symptoms in the NHANES National Epidemiological Survey

Per- and polyfluorinated substances (PFASs): Environmental challenges

Acute exposure to DE‐71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae

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