Abnormal erythrocyte fatty acid composition in first-diagnosed, drug-naïve patients with depression

Wang, Lu; Liu, Ting; Guo, Jimin; Zhao, Ting; Tang, Hui; Jin, Kun; Li, Li; Yang, Xue; Yang, Rong; Chen, Jindong; Tang, Mimi

doi:10.1016/j.jad.2022.09.023

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…Third, as our study is cross-sectional, future longitudinal studies are needed to confirm the role of FA changes as a trait marker and to investigate the influence of illness stages. Fourth, as FA abnormalities have been reported in other neuropsychiatric disorders such as major depression (69), further research is necessary to confirm our findings' disease specificity and investigate the potential influence of comorbid anxiety/depressive symptoms in patients with ARMS. Fifth, we failed to investigate the duration of symptom of ARMS that might have affected the results.…”

Section: Limitationsmentioning

confidence: 59%

Analysis of polyunsaturated fatty acids in antipsychotic-free individuals with at-risk mental state and patients with first-episode schizophrenia

Higuchi

Sumiyoshi

et al. 2023

Front. Psychiatry

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IntroductionAbnormalities in membrane phospholipids are considered one of the pathophysiological backgrounds for schizophrenia. This study, explores the fatty acid composition of erythrocyte membranes and its association with clinical characteristics in two groups: individuals with an at-risk mental state (ARMS) and patients experiencing their first-episode of schizophrenia (FES).Materials and methodsThis study measured erythrocyte membrane fatty acids in 72 antipsychotic-free individuals with ARMS, 18 antipsychotic-free patients with FES, and 39 healthy volunteers. Clinical symptoms and cognitive and social functions were assessed using the Positive and Negative Syndrome Scale (PANSS), Brief Assessment of Cognition in Schizophrenia (BACS), Schizophrenia Cognition Rating Scale (SCoRS), and Social and Occupational Functioning Assessment Scale (SOFAS).ResultsEicosapentaenoic and docosapentaenoic acid levels were lower in the ARMS and FES groups than in the healthy control group. In contrast, nervonic acid (NA) levels were markedly higher in the ARMS and FES groups than in the controls, while only the FES group showed higher levels of arachidonic acid. Oleic acid and NA levels were significantly associated with PANSS scores in both the FES and ARMS groups, particularly for the negative and general subscores. However, the patient groups had no significant associations between the fatty acid composition and the BACS, SCoRS, and SOFAS scores. Furthermore, the baseline fatty acid composition did not differ between the ARMS individuals who later developed psychosis (N = 6) and those who were followed for more than 2 years without developing psychosis onset (N = 30).DiscussionThe findings suggest that abnormal fatty acid compositions may be shared in the early stages of schizophrenia and the clinical high-risk state for psychosis and may serve as vulnerability markers of psychopathology.

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Section: Limitationsmentioning

confidence: 59%

Analysis of polyunsaturated fatty acids in antipsychotic-free individuals with at-risk mental state and patients with first-episode schizophrenia

Higuchi

Sumiyoshi

et al. 2023

Front. Psychiatry

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“…The researchers randomly screened 139 first-diagnosed, drug-naïve depressed patients and 55 healthy controls (HCs) in the Mental Health Center of the Second Xiangya Hospital of Central South University. Data were drawn from the previous study exploring the relationship of fatty acids (FAs) composition with the presence and clinical characteristics of first-diagnosed, drug-naïve patients with depression; results of these studies have been previously published ( Wang et al, 2022 ). Each patient was evaluated by two experienced psychiatrists for a diagnosis of depression according to the DSM-5 (Diagnostic and Statistical Manual of Mental Disorder, fifth version).…”

Section: Methodsmentioning

confidence: 99%

“…The properties of lipid microdomains are considered biomarkers for individuals with depression ( Liu et al, 2018 ), where the distribution of raft-associated proteins and the molecular architecture of lipid rafts are particularly vulnerable to modification by PUFAs ( Simopoulos, 2011 ). In a previous study, we found a relationship between fatty acids and depressive symptoms and demonstrated that there are elevated levels of trans fatty acids (TFAs) and n-6 PUFAs in patients with depression ( Wang et al, 2022 ). Notably, in patients with depression, the imbalance of fatty acids and depression symptoms could potentially be reversed by PUFAs or antidepressants ( Kapoor et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disorders

Wang,

Liu,

Guo

et al. 2023

Front. Pharmacol.

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Background: Since depression, sex hormones, and fatty acid status are interrelated, it is important to understand their relationships. In this study, we aimed to investigate sex differences in erythrocyte membrane fatty acid composition among first-diagnosed, drug-naïve patients with major depressive disorders.Methods: The study included 139 individuals with first-diagnosed, drug-naïve depression (male/female = 48/91) and 55 healthy controls (male/female = 24/31). The levels of erythrocyte membrane fatty acids were analyzed to compare the difference between males and females in both patients with depression and healthy controls, as well as to study their correlation with depressive symptoms.Results: In first-diagnosed, drug-naïve patients with major depressive disorders, sex disparities were observed in the levels of erythrocyte saturated fatty acids (SFAs) and n-6 PUFAs (such as C18:0, C20:4n6 and C22:4n6), where higher levels evident in females compared to in males. We found a noteworthy correlation between fatty acid levels and depressive symptoms, in which there is a significant association between female patients and depression but a weaker association between male patients and depression.Conclusion: Our findings demonstrate higher levels of n-6 PUFAs and SFAs in female patients with depression. The relationship between fatty acid composition and depressive symptoms was more prominent in females than males. These findings highlight the significance of considering sex as a crucial and interconnected factor in future investigations and potential adjunctive treatment for mood disorders by targeting fatty acid metabolism.

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Secondary analysis of neurotransmitter metabolism and cognitive function in first-diagnosed, drug-naïve adult patients with major depressive disorder

Zhao,

Luo,

Liu

et al. 2024

Behavioural Brain Research

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Abnormal erythrocyte fatty acid composition in first-diagnosed, drug-naïve patients with depression

Cited by 5 publications

References 49 publications

Analysis of polyunsaturated fatty acids in antipsychotic-free individuals with at-risk mental state and patients with first-episode schizophrenia

Analysis of polyunsaturated fatty acids in antipsychotic-free individuals with at-risk mental state and patients with first-episode schizophrenia

Sex differences in erythrocyte fatty acid composition of first-diagnosed, drug-naïve patients with major depressive disorders

Secondary analysis of neurotransmitter metabolism and cognitive function in first-diagnosed, drug-naïve adult patients with major depressive disorder

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