Abnormal expression of menin predicts the pathogenesis and poor prognosis of adult gliomas

Wang, Zhanfeng; Hong, Xinyu; Zhu, Ling-Yu; Zhang, Li; Qiu, Huan; Zhang, Yuanyuan; Yuan, Min; Zhao, Xingli; Zheng, Qi-Fan; Jin, Guang‐Hui

doi:10.1038/s41417-019-0127-5

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…MEN1 expression was activated in 44.4% of adult gliomas and predicted poor prognosis of patients with glioma (45). Importantly, MEN1 inhibitors significantly decreased the proliferation of adult glioma cells (45). CLNS1A is a co-factor of methyltransferase PRMT5.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Biological Significances of a Methyltransferase-Related Signature in Diffuse Glioma

Zhang

Liu

et al. 2020

Front. Oncol.

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Section: Discussionmentioning

confidence: 99%

Clinical and Biological Significances of a Methyltransferase-Related Signature in Diffuse Glioma

Zhang

Liu

et al. 2020

Front. Oncol.

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“…Similarly, it was demonstrated that the small molecule EPZ-5676 has a modest clinical activity reducing the proliferation of MLL-rearranged cells and inducing apoptosis by targeting the enzymatic core of DOT1L, a H3K79 methyltransferase recruited to fusion partners of KMT2A in disease-linked translocations and required for leukemogenesis [ 69 , 70 , 71 , 72 ]. Advances in treating MLL-rearranged leukemia were also achieved by using small molecules to block the KMT2A binding site on Menin, a protein encoded by MEN1 and required for oncogenic transformation, leading to the inhibition of the aberrant leukemogenic transcription program [ 73 , 74 , 75 , 76 , 77 ].…”

Section: Epigenetic Strategies For Pharmacological Approachesmentioning

confidence: 99%

KMT2A: Umbrella Gene for Multiple Diseases

Castiglioni

Fede

Bernardelli

et al. 2022

Genes

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KMT2A (Lysine methyltransferase 2A) is a member of the epigenetic machinery, encoding a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation. KMT2A has a crucial role in gene expression, thus it is associated to pathological conditions when found mutated. KMT2A germinal mutations are associated to Wiedemann–Steiner syndrome and also in patients with initial clinical diagnosis of several other chromatinopathies (i.e., Coffin–Siris syndromes, Kabuki syndrome, Cornelia De Lange syndrome, Rubinstein–Taybi syndrome), sharing an overlapping phenotype. On the other hand, KMT2A somatic mutations have been reported in several tumors, mainly blood malignancies. Due to its evolutionary conservation, the role of KMT2A in embryonic development, hematopoiesis and neurodevelopment has been explored in different animal models, and in recent decades, epigenetic treatments for disorders linked to KMT2A dysfunction have been extensively investigated. To note, pharmaceutical compounds acting on tumors characterized by KMT2A mutations have been formulated, and even nutritional interventions for chromatinopathies have become the object of study due to the role of microbiota in epigenetic regulation.

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A novel brain targeting MnOx-based MI-3 nanoplatform for immunogenic cell death initiated high-efficiency antitumor immunity against orthotopic glioblastoma

Wang,

et al. 2024

Chemical Engineering Journal

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Abnormal expression of menin predicts the pathogenesis and poor prognosis of adult gliomas

Cited by 4 publications

References 36 publications

Clinical and Biological Significances of a Methyltransferase-Related Signature in Diffuse Glioma

Clinical and Biological Significances of a Methyltransferase-Related Signature in Diffuse Glioma

KMT2A: Umbrella Gene for Multiple Diseases

A novel brain targeting MnOx-based MI-3 nanoplatform for immunogenic cell death initiated high-efficiency antitumor immunity against orthotopic glioblastoma

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