“…As these patients are the most likely to require ophthalmic examination, any ability to detect or stabilise temporal variation in physiology would be of great benefit to clinicians. For example, patients with Down and Williams syndrome, Parkinson's and Hodgkin's disease, or toddlers, or amblyopia, juvenile and age related macular degeneration patients are known to exhibit abnormal fixation . These are seen as ocular flutter, micro‐saccades, micro‐tremors and Nystagmus .…”