Abnormal functional connectivity between the anterior cingulate and the default mode network in drug-naïve boys with attention deficit hyperactivity disorder

Sun, Li; Cao, Qingjiu; Long, Xiangyu; Sui, Manqiu; Cao, Xiaohua; Zhu, Chaozhe; Zuo, Xi‐Nian; An, Li; Song, Yan; Zang, Yu‐Feng; Wang, Yufeng

doi:10.1016/j.pscychresns.2011.07.001

Cited by 151 publications

(137 citation statements)

References 48 publications

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“…Task-based studies have provided evidence for elevated DMN levels in ADHD during task processing [14,24] which has been related to attentional deficits [11][12][13]. In terms of intrinsic network organization, studies have suggested diminished antagonistic relationship between DMN and attention networks which may lead to excess task-related DMN [37,62,66,67]. However, more recent models have introduced the crucial role of the SN to control the state-dependent switching between DMN and task-related attention networks [15].…”

Section: Discussionmentioning

confidence: 99%

Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Sidlauskaite

Sonuga‐Barke

Roeyers

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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Deficits in task-related attentional engagement in attention-deficit/hyperactivity disorder (ADHD) have been hypothesized to be due to altered interrelationships between attention, default mode and salience networks. We examined the intrinsic connectivity during rest within and between these networks. Six minutes resting state scans were obtained. Using a network-based approach, connectivity within and between the dorsal and ventral attention, the default mode and the salience networks was compared between the ADHD and control group.The ADHD group displayed hyperconnectivity between the two attention networks and within the default mode and ventral attention network. The salience network was hypoconnected to the dorsal attention network. There were trends towards hyperconnectivity within the dorsal attention network and between the salience and ventral attention network in ADHD.Connectivity within and between other networks was unrelated to ADHD. Our findings highlight the altered connectivity within and between attention networks, and between them and the salience network in ADHD. One hypothesis to be tested in future studies is that individuals with ADHD are affected by an imbalance between ventral and dorsal attention systems with the former playing a dominant role during task engagement making individuals with ADHD highly susceptible to distraction by salient task-irrelevant stimuli.

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Section: Discussionmentioning

confidence: 99%

Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Sidlauskaite

Sonuga‐Barke

Roeyers

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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“…For 33 boys with ADHD as well as 32 healthy control subjects, Li et al [19] calculate ALFF and seed-based FC across subjects, revealing that aberrant ALFF in the ADHD group appears in the globus pallidus, superior frontal gyrus (SFG), and orbital frontal cortex (OFC) compared to healthy controls. Compared with 23 normal controls, Sun et al [20] discover that the dorsal anterior cingulate cortex (ACC) in 19 drug-naïve boys with ADHD shows a significantly decreased negative FC within the default mode network (DMN), including the dorsomedial prefrontal cortex and the posterior cingulate cortex (PCC).…”

Section: Introductionmentioning

confidence: 99%

Different Developmental Pattern of Brain Activities in ADHD: A Study of Resting-State fMRI

et al. 2018

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There are distinct symptoms for attention deficit hyperactivity disorder (ADHD) at different ages. To explore the developmental mechanism of ADHD from childhood to adolescence, patients from different age groups with ADHD drawn from a large dataset should be investigated. In this study, we hypothesized that there are significant differences in the developmental patterns of local and global brain activities between ADHD and typically developing (TD) individuals. Three voxel-based measurements and the functional connectivity (FC) of the brain networks were extracted from resting-state functional magnetic resonance imaging (fMRI) of both ADHD and TD participants 7–16 years of age. The topological properties of brain networks in both groups were also analyzed, including hubs, hemispheric symmetry, together with local and global efficiency. The results showed, from the local perspective, that the ADHD group had abnormal amplitude of low-frequency fluctuation, fractional amplitude of low-frequency fluctuation, and regional homogeneity in the medial orbital frontal cortex, anterior cingulate cortex, postcentral gyrus, thalamus, precuneus, and cerebellum compared with the TD group. From the global perspective, the aberrant FC between multiple networks, such as the default mode network (DMN), the attention network, and the executive control network, might directly contribute to symptom differences in childhood and adolescence in ADHD patients. Finally, from the developmental perspective, there was delayed maturation of brain networks in the ADHD group, especially in the DMN. Overall, we presented the differences in brain networks between the ADHD and TD group from multiple perspectives and demonstrated the developmental abnormality of brain networks in ADHD patients, contributing to the study of the etiology of ADHD.

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“…Thus, the present study did not recruit children characterized by chronic irritability, as previous task- based studies of frustration responses have (Perlman et al, 2015; Rich et al, 2011), but rather focused on children with frequent, impairing outbursts. Further, our previous work suggests that a majority of young children with severe temper outbursts have ADHD (Roy et al, 2013), which is characterized by altered function (Dickstein, Bannon, Castellanos, & Milham, 2006), structure, (Makris et al, 2008; Seidman et al, 2006), and connectivity (Castellanos et al, 2008; Sun et al, 2012) of the ACC. Therefore, to address the aim of the study to identify neural features associated with severe temper outbursts, we compare children with severe outbursts to children with ADHD who do not have severe outbursts.…”

mentioning

confidence: 99%

Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts

et al. 2017

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Severe temper outbursts in children are associated with impaired school and family functioning and may contribute to negative outcomes. These outbursts can be conceptualized as excessive frustration responses reflecting reduced emotion regulation capacity. The anterior cingulate cortex (ACC) has been implicated in negative affect as well as emotional control, and exhibits disrupted function in children with elevated irritability and outbursts. This study examined the intrinsic functional connectivity (iFC) of a region of the ACC, the anterior midcingulate cortex (aMCC), in 5–9 year old children with severe temper outbursts (STO; n=20), comparing them to children with ADHD without outbursts (ADHD; n=18). Additional analyses compared results to a sample of healthy children (HC; n=18) and examined specific associations with behavioral and emotional dysregulation. Compared to the ADHD group, STO children exhibited reduced iFC between the aMCC and surrounding regions of the ACC, and increased iFC between the aMCC and precuneus. These differences were also seen between the STO and HC groups; ADHD and HC groups did not differ. Specificity analyses found associations between aMCC-ACC connectivity and hyperactivity, and between aMCC-precuneus iFC and emotion dysregulation. Disruption in aMCC networks may underlie the behavioral and emotional dysregulation characteristic of children with severe temper outbursts.

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Abnormal functional connectivity between the anterior cingulate and the default mode network in drug-naïve boys with attention deficit hyperactivity disorder

Cited by 151 publications

References 48 publications

Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Different Developmental Pattern of Brain Activities in ADHD: A Study of Resting-State fMRI

Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts

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