Abnormal functional connectivity density in sleep-deprived subjects

Yang, Liu; Yu, Lei; Wang, Lubin; Chen, Pinhong; Cheng, Shan; Chen, Shanshan; Sun, Jicheng; Li, Yanyan; Wang, Yihan; Hu, Wendong; Zheng, Yang

doi:10.1007/s11682-018-9829-9

Cited by 22 publications

(18 citation statements)

References 40 publications

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“…Tüshaus et al (2017) observed that sleep pressure led to significant changes in the FC between resting-state networks as determined using independent components analysis. Yang et al (2018) reported that sleep deprivation led to decreases in FC density (FCD) in brain regions including the posterior cingulate cortex and precuneus and increases in sensory integration and arousal regulating areas, such as thalamus.…”

Section: Sleep Deprivationmentioning

confidence: 99%

Vigilance Effects in Resting-State fMRI

Liu

Falahpour

2020

Front. Neurosci.

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Measures of resting-state functional magnetic resonance imaging (rsfMRI) activity have been shown to be sensitive to cognitive function and disease state. However, there is growing evidence that variations in vigilance can lead to pronounced and spatially widespread differences in resting-state brain activity. Unless properly accounted for, differences in vigilance can give rise to changes in resting-state activity that can be misinterpreted as primary cognitive or disease-related effects. In this paper, we examine in detail the link between vigilance and rsfMRI measures, such as signal variance and functional connectivity. We consider how state changes due to factors such as caffeine and sleep deprivation affect both vigilance and rsfMRI measures and review emerging approaches and methodological challenges for the estimation and interpretation of vigilance effects.

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Section: Sleep Deprivationmentioning

confidence: 99%

Vigilance Effects in Resting-State fMRI

Liu

Falahpour

2020

Front. Neurosci.

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“…Except for these two brain regions, studies, which used resting state fMRI, also showed decreased ALFF in the precuneus, angular gyrus, and thalamus [11,32,43]. In addition, SD disturbed functional connectivity and long/short range of functional connectivity density in the precuneus, posterior cingulate cortex, parietal lobe, and prefrontal cortex [32,43,47]. Nearly almost all of these brain areas, which showed abnormal activation, spontaneous activity, and functional connectivity, were observed in our study as well.…”

Section: Working Memory and Alff Changes After Sdmentioning

confidence: 99%

High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

Jiang

McClure

et al. 2019

Neural Plasticity

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Objective. To investigate whether and how the working memory impairment induced by sleep deprivation (SD) could be recovered by using repetitive transcranial magnetic stimulation (rTMS), as well as to clarify the corresponding brain activity changes. Methods. Seventeen healthy adults received one session of 5.0 Hz rTMS over the left dorsolateral prefrontal cortex (DLPFC) following 24 hours of SD. Resting state functional magnetic resonance imaging (fMRI) and working memory test were performed during a rested waking period, after SD and rTMS. The amplitude of low-frequency fluctuations (ALFF) was used to detect the spontaneous neural activity changes after both SD and rTMS. The relationship between ALFF and the performance of working memory was also assessed by using correlation analysis. Results. After SD, the participants exhibited lower response accuracies and longer reaction times on the working memory tests of letters and numbers. The decreased response accuracy of numbers was significantly improved after rTMS similarly to the state of the rested waking period after a normal night of sleep. ALFF values decreased from the rested waking period state to the state of SD in the brain regions involving the frontal gyrus, precuneus, angular gyrus, and parietal lobe which showed significantly increased ALFF after rTMS. Furthermore, significantly positive correlations were observed between changes of response accuracy and the changes of ALFF value of the inferior frontal gyrus and supramarginal gyrus. Conclusion. These results indicate that high-frequency rTMS applied over left DLPFC may contribute to the recovery of the impaired working memory after SD by modulating the neural activity of related brain regions.

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“…Consistent with the findings of previous studies, our results suggest that the mPFC and SMA are important nodes in the neural substrate of sleep disorders. Using the same FCD method, Yang et al 27 conducted a sleep deprivation study. After 36 hours of sleep deprivation, healthy participants showed decreased long/short-range FCD in the mPFC and increased long/short-range FCD in sensory integration and arousal-regulating areas, including the occipital–temporal cortex.…”

Section: Discussionmentioning

confidence: 99%

Functional Connectivity Density in the Sensorimotor Area is Associated with Sleep Latency in Patients with Primary Insomnia

Ji¹,

Dai²,

Guo³

et al. 2022

NDT

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Objective: It is unclear whether the patterns of functional connectivity density (FCD) differ between patients with primary insomnia (PI) and healthy subjects. In the present study, we investigated the features of FCD in patients with PI using resting-state functional MRI (rsfMRI). Methods: rsfMRI datasets of 32 patients with PI and 34 healthy controls (HCs) were obtained using a 3-Tesla scanner. FCD analysis was performed to compare voxels with abnormal whole-brain functional connectivity with other voxels among patients with PI and HCs. Abnormal brain regions were then used as seed points for FC analysis. Results: Compared with HCs, patients with PI exhibited significantly decreased FCD in the left medial frontal gyrus and increased FCD in the left supplementary motor area (SMA). With the left medial frontal gyrus as the seed point, patients with PI showed decreased FC between the left medial frontal gyrus and the left fusiform gyrus compared with HCs. With the left SMA as the seed point, patients with PI exhibited increased FC between the left SMA and the right anterior cingulate gyrus. Correlation analysis revealed that the increased FCD values in the left SMA were positively correlated with sleep latency in patients with PI. Conclusion: Default-mode network and SMA dysfunctions may be related to the pathophysiology of PI.

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Abnormal functional connectivity density in sleep-deprived subjects

Cited by 22 publications

References 40 publications

Vigilance Effects in Resting-State fMRI

Vigilance Effects in Resting-State fMRI

High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

Functional Connectivity Density in the Sensorimotor Area is Associated with Sleep Latency in Patients with Primary Insomnia

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