Abnormal functioning of the semantic network in schizophrenia patients with thought disorganization. An exemplar production task

Brébion, Gildas; Stephan‐Otto, Christian; Huerta‐Ramos, Elena; Usall, Judith; Ochoa, Susana; Roca, Mercedes; Abellán-Vega, Helena; Haro, Josep María

doi:10.1016/j.psychres.2012.08.007

Cited by 10 publications

(10 citation statements)

References 23 publications

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“…The overactivation hypothesis in TD was supported by evidence for over-inclusiveness of categories (Brébion et al, 2013) and increased direct priming in TD-specific patients (Safadi, Lichtenstein-Vidne, Dobrusin, & Henik, 2013;, but more so from studies of indirect pairs. Indirect priming was found to be increased in patients with TD (Moritz et al, 2001;Moritz, Woodward, Küppers, Lausen, & Schickel, 2003;.…”

Section: Overactivation In Smmentioning

confidence: 97%

Assessing the Relationship between Semantic Processing and Thought Disorder Symptoms in Schizophrenia

Tan

Neill

Rossell

2015

J Int Neuropsychol Soc

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Aberrant semantic processing has been linked to the etiology of formal thought disorder (TD) symptoms in schizophrenia. In this cross-sectional study, two prominent theories, overactivation and disorganized structure of semantic memory (SM), were examined in relation to TD symptoms using the continuum approach across two established semantic tasks (direct/indirect semantic priming and categorical fluency). The aim was to examine the validity of the two TD theories in relation to TD symptoms in schizophrenia. Greater direct and indirect priming, fluency productivity and category errors were expected if the data supported the overactivation theory. Reduced fluency productivity and increased category errors would be characteristic of disorganized storage. Fifty-seven schizophrenia/schizoaffective disorder patients and 48 controls completed a clinical assessment and the semantic tasks. There was significantly reduced direct priming in patients compared to controls (p<.05), while indirect priming was not significantly different; there was no association between TD and degree of priming. Patients produced more category-inappropriate words (p<.005) than controls, which was related to increasing severity of circumstantiality. The pattern of results was more indicative of a disorganized SM storage problem in this sample. This phenomenon may underlie some TD symptoms in general schizophrenia. The findings strengthen the relationship between SM deficits and TD symptoms, though this appears to differ between individual symptoms. The authors discuss the value of the continuum approach in addressing research questions in TD etiology. Given low levels of TD in this study, replication of these findings in a sample with greater TD is desirable.

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Section: Overactivation In Smmentioning

confidence: 97%

Assessing the Relationship between Semantic Processing and Thought Disorder Symptoms in Schizophrenia

Tan

Neill

Rossell

2015

J Int Neuropsychol Soc

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“…Recent investigations suggest that associative binding and conceptual priming may contribute to familiarity (Rhodes and Donaldson, 2007;Harlow et al, 2010;Wang and Yonelinas, 2012), and some models treat familiarity as separate from episodic and semantic memories, grouping it with long-term priming (e.g., Henke, 2010). On the other hand, recent work suggests failures to process the semantic relations between items, semantic broadening and overinclusive thinking in schizophrenia (e.g., Brébion et al, 2013). Similarly, the inability to implement semantic processing strategies has been reported in a false memory paradigm, whereas the patients' implicit retrieval of meanings from their semantic lexicon was spared (Paz-Alonso et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Perceptually or conceptually driven recognition: On the specificities of the memory deficit in schizophrenia

Guillaume

Thomas

Faget

et al. 2015

Psychiatry Research

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“…All of the patients included in the study were consecutive outpatients who had been referred by their primary care physician to the Parkinson's disease ambulatory care facilities of the IRCCS Santa Lucia Foundation in Rome. The diagnosis of idiopathic PD was made by a neurologist according to the London Brain Bank criteria [21]. Exclusion criteria for PD patients included (i) disease duration ≥ 5 years, (ii) diagnosis of dementia based on clinical criteria [22] and confirmed by a Mini-Mental State Examination [23] score < 26, and (iii) presence of other neurological and/or psychiatric illnesses in the patient's clinical history.…”

Section: Methodsmentioning

confidence: 99%

Does Dopamine Depletion Trigger a Spreader Lexical-Semantic Activation in Parkinson’s Disease? Evidence from a Study Based on Word Fluency Tasks

Zabberoni

Carlesimo

Peppe

et al. 2017

Parkinson's Disease

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It has been hypothesised that, in Parkinson's disease (PD), dopamine might modulate spreading activation of lexical-semantic representations. We aimed to investigate this hypothesis in individuals with PD without dementia by assessing word frequency and typicality in verbal fluency tasks. We predicted that the average values of both of these parameters would be lower in PD patients with respect to healthy controls (HC). We administered letter-cued and category-cued fluency tasks to early PD patients in two experimental conditions: the tasks were administered both after 12–18 hours of dopaminergic stimulation withdrawal (“OFF” condition) and after the first daily dose of dopaminergic therapy (“ON” condition). HC were also given the two tasks in two conditions with the same intersession delay as PD patients but without taking drugs. Results showed that in both OFF and ON treatment conditions PD patients did not differ from HC in word frequency or typicality. Moreover, in the PD group, no significant difference was found between the experimental conditions. Our results show that semantic spreading was not altered in the PD sample examined; this suggests that in early PD the functioning of the semantic system is relatively independent from the activity of dopamine brain networks.

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Abnormal functioning of the semantic network in schizophrenia patients with thought disorganization. An exemplar production task

Cited by 10 publications

References 23 publications

Assessing the Relationship between Semantic Processing and Thought Disorder Symptoms in Schizophrenia

Assessing the Relationship between Semantic Processing and Thought Disorder Symptoms in Schizophrenia

Perceptually or conceptually driven recognition: On the specificities of the memory deficit in schizophrenia

Does Dopamine Depletion Trigger a Spreader Lexical-Semantic Activation in Parkinson’s Disease? Evidence from a Study Based on Word Fluency Tasks

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