Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients

Chern, Jimmy P. S.; Lin, Kai‐Hsin; Lu, Meng‐Yao; Lin, Dong; Lin, Kuo‐Sin; Chen, Jong-Dar; Fu, Cheng-Chung

doi:10.2337/diacare.24.5.850

Cited by 79 publications

(83 citation statements)

References 28 publications

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“…50% of twenty patients studied by Suadek et al [43] had abnormal glucose tolerance. Sixteen of eighty two patients interviewed by Chern et al had diabetes and risk was increased by co-infection with hepatitis C [44]. Gamberini et al [44] followed up 273 thalassaemic patients over a period of thirty years and have shown that 42 patients developed insulin dependent diabetes mellitus.…”

Section: Glucose Intolerance and Diabetes Mellitusmentioning

confidence: 99%

“…Sixteen of eighty two patients interviewed by Chern et al had diabetes and risk was increased by co-infection with hepatitis C [44]. Gamberini et al [44] followed up 273 thalassaemic patients over a period of thirty years and have shown that 42 patients developed insulin dependent diabetes mellitus. They demonstrated that prevalence progressively increased with time.…”

Section: Glucose Intolerance and Diabetes Mellitusmentioning

confidence: 99%

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A Review of Endocrine Disorders in Thalassaemia

De¹,

Mistry²,

Wright³

et al. 2014

OJEMD

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Endocrine dysfunction in thalassaemia is amongst the most common complication and is principally attributed to excessive iron overload and suboptimal chelation. The prevalence is quite high particularly in multiethnic populations but determining the prevalence is often difficult due to the widespread heterogeneity of the population and timing of exposure to chelation therapy. Disturbances in growth, pubertal development, abnormal gonadal functions, impaired thyroid, parathyroid and adrenal functions, diabetes and disorderly bone growth are commonly encountered. Early detection and institution of appropriate transfusion regimen and chelation therapy and treatment of complications are the keys to managing this population including regular follow. In this article, we review the literature in relation to the various endocrine complications encountered in thalassaemia.

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Section: Glucose Intolerance and Diabetes Mellitusmentioning

confidence: 99%

Section: Glucose Intolerance and Diabetes Mellitusmentioning

confidence: 99%

A Review of Endocrine Disorders in Thalassaemia

De¹,

Mistry²,

Wright³

et al. 2014

OJEMD

View full text Add to dashboard Cite

show abstract

“…This is mostly attributed to changes in lifestyle and increase in obesity (Matthews and Matthews 2011). Interestingly, several reports indicate increased risk of diabetes after organ transplant (Kasiske et al 2003;Carey et al 2012) and blood transfusion (Chern et al 2001). New-onset diabetes after organ transplant (NODT), such as kidney transplant, is frequently ob-served in recipients (Kasiske et al 2003;Carey et al 2012).…”

Section: Prion-like Transmission Of Protein Aggregates In "Real Life"mentioning

confidence: 99%

“…Moreover, a recent report indicates that diseased hearts from obese, prediabetic individuals exhibit oligomeric IAPP, suggesting that the process of IAPP accumulation may begin decades before the onset of overt T2D (Despa et al 2012). Increased risk of developing impairment in glucose metabolism and diabetes has also been noted in individuals who have received chronic blood transfusion (Chern et al 2001;Shamshirsaz et al 2003). Iron-overloadmediated toxicity in the endocrine system is believed to be the underlying cause.…”

Section: Prion-like Transmission Of Protein Aggregates In "Real Life"mentioning

confidence: 99%

Prion-Like Protein Aggregates and Type 2 Diabetes

Mukherjee

Soto

2017

Cold Spring Harb Perspect Med

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Type 2 diabetes (T2D) is a highly prevalent metabolic disease characterized by chronic insulin resistance and b-cell dysfunction and loss, leading to impaired insulin release and hyperglycemia. Although the mechanism responsible for b-cell dysfunction and death is not completely understood, recent findings suggest that the accumulation of misfolded aggregates of the islet amyloid polypeptide (IAPP) in the islets of Langerhans may play an important role in pancreatic damage. Misfolding and aggregation of diverse proteins and their accumulation as amyloid in different organs is the hallmark feature in a group of chronic, degenerative diseases termed protein misfolding disorders (PMDs). PMDs include highly prevalent human illnesses such as Alzheimer's and Parkinson's disease, as well as more than 25 rarer disorders. Among them, prion diseases are unique because the pathology can be transmitted by a proteinaceous infectious agent, termed a prion, which induces disease by propagating protein misfolding and aggregation. This phenomenon has a striking resemblance to the process of protein misfolding and aggregation in all of the PMDs, suggesting that misfolded aggregates have an intrinsic potential to be transmissible. Indeed, recent studies have shown that the pathological hallmarks of various PMDs can be induced in vivo under experimental conditions by inoculating tissue extracts containing protein aggregates into animal models. In this review, we describe our current understanding of the molecular mechanism underlying the prion-like transmission of protein aggregates and its possible role in T2D.

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“…The first mechanism involves decrease in insulin production either by direct impairment of insulin excretory function by chronic iron overload or immune system activation against pancreatic b-cells in b-thalassaemia patients. 16,17 The second mechanism involves decreased insulin sensitivity with reduced hepatic release of insulin. 8,18 Thyroid dysfunction is another frequently occurring endocrine complication.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of hypothyroidism, diabetes mellitus and delayed puberty in patients of thalassemia major in a tertiary care center of Jammu province, Jammu Kashmir, India

et al. 2017

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Background: Thalassemia is a common genetic disorder which is associated with a lot of complications. Frequent blood transfusions result in increased iron deposition in various tissues leading to dysfunction of many organs of our body. Endocrine disorders constitute a major part of such complications increasing the morbidity of thalassemia manifold in the affected patients.Methods: This is a prospective study carried out in 64 thalassemia major patients attending thalassemia day care centre at SMGS Hospital Jammu from December 2014 to November 2015. Patients were examined and investigated for presence of one or more endocrine disorders including diabetes mellitus, hypothyroidism and delayed puberty.Results: Endocrine disorders were detected in a total of 22 patients. Diabetes mellitus was detected in 4.7% (n=3) patients, hypothyroidism in 4.7% (n=3) patients and delayed puberty was found in 26.6% (n=17) patients. Mean serum ferritin level was found to be 2885.5 ng/ml and there was no significant difference in patients affected with endocrine disorder and those without any endocrine disorder.Conclusions: Endocrine complications occur commonly in patients of thalassemia major. Increasing life span of thalassemia patients has increased the number of patients living with these disorders. A lot of morbidity occurs due to the presence of one or more of these disorders. Hence timely detection of these disorders by screening in all patients of thalassemia should be done to initiate treatment at the earliest so as to limit the morbidity caused by these disorders.

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Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients

Cited by 79 publications

References 28 publications

A Review of Endocrine Disorders in Thalassaemia

A Review of Endocrine Disorders in Thalassaemia

Prion-Like Protein Aggregates and Type 2 Diabetes

Prevalence of hypothyroidism, diabetes mellitus and delayed puberty in patients of thalassemia major in a tertiary care center of Jammu province, Jammu Kashmir, India

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