Abnormal intestinal motor patterns explain enteric colonization with gram-negative bacilli in late radiation enteropathy

Husebye, Einar; Skar, Viggo; Høverstad, T; Iversen, T.; Melby, K

doi:10.1016/0016-5085(95)90565-0

Cited by 161 publications

(150 citation statements)

References 57 publications

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“…Antibiotics for small bowel bacterial overgrowth Damage to the small bowel creates areas of dysmotility and stasis leading to bacterial overgrowth [Husebye et al 1995]. Unlike the colon, which is rich in bacteria, the small bowel usually has fewer than 104 organisms per millilitre [Quigley and Quera, 2006].…”

Section: Secondary Effects Of Chronic Radiationinduced Small Bowel DImentioning

confidence: 99%

Radiation-induced small bowel disease: latest developments and clinical guidance

Stacey

Green

2013

Therapeutic Advances in Chronic Disease

187

127

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Ionizing radiation is commonly used to treat a number of malignancies. Although highly effective and now more targeted, many patients suffer side effects. The number of cancer survivors has increased and so there are more patients presenting with symptoms that have arisen as a result of radiotherapy. Radiation damage to small bowel tissue can cause acute or chronic radiation enteritis producing symptoms such as pain, bloating, nausea, faecal urgency, diarrhoea and rectal bleeding which can have a significant impact on patient's quality of life. This review outlines the pathogenesis of radiation injury to the small bowel along with the prevention of radiation damage via radiotherapy techniques plus medications such as angiotensin-converting enzyme inhibitors, statins and probiotics. It also covers the treatment of both acute and chronic radiation enteritis via a variety of medical (including hyperbaric oxygen), dietetic, endoscopic and surgical therapies.

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Section: Secondary Effects Of Chronic Radiationinduced Small Bowel DImentioning

confidence: 99%

Radiation-induced small bowel disease: latest developments and clinical guidance

Stacey

Green

2013

Therapeutic Advances in Chronic Disease

187

127

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“…En contraste, estos sínto-mas pueden causar confusión diagnóstica si se presentan en pacientes con SII, dispepsia pseudoulcerosa, enfermedad celíaca y enfermedad de Crohn. Los exámenes de laboratorio revelan anemia, generalmente macrocítica, debida a la malabsorción de vitamina B 12 por unión e incorporación de esta vitamina en las bacterias. Sin embargo, el sangrado por úlceras y erosiones puede causar anemia microcítica 34 .…”

Section: A R T í C U L O D E R E V I S I ó Nunclassified

“…En pacientes con déficit de vitamina B 12 , el SBI puede ser diagnosticado durante la evaluación del test de Schilling si la administración de antibióti-cos normaliza la absorción de vitamina B 12 .…”

Section: Tabla 3 Métodos Para El Diagnóstico De Sobrecrecimiento Bacunclassified

Sobrecrecimiento bacteriano intestinal: An update

Quera

Quigley

2005

Rev. méd. Chile

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Small intestinal bacterial overgrowth (SIBO) is characterized by nutrient malabsorption, associated with an excessive number of bacteria in the proximal ARTÍCULO DE REVISIÓNCorrespondencia a: Dr. Rodrigo Quera P. Sección de Gastroenterología, Hospital Clínico de la Universidad de Chile. Santos Dumont 999, Independencia, Santiago. Telé-fono: 6788350. E mail: rodrigoquera@yahoo.es L a microflora gastrointestinal humana es un complejo ecosistema de aproximadamente 500 especies bacterianas que colonizan el tracto alimentario poco después del nacimiento y que mantienen su composición relativamente constante a través de la vida 1 . Normalmente, sólo un pequeño número es encontrado en el intestino delgado al compararlos con los existentes en el colon. Dado que la flora bacteriana es excluida del intestino delgado, se evita su competencia con el hospedero en el sitio de digestión y absorción de alimentos. Cultivos de contenido yeyunal pueden no detectar bacterias hasta en 33% de los sujetos sanos. Cuando las bacterias están presentes, ellas son usualmente lactobacillus, enterococo, estreptococo, y otras bacterias aeróbicas gram (+) o anaerobios facultativos. El recuento bacteriano raramente supera las 10 4 unidades formadoras de colonias (UFC). La microbiología del íleon terminal representa una área de transición entre la escasez de bacterias en el yeyuno, principalmente especies aeróbicas, y la densa población de bacterias anaeróbicas encontradas en el colon. El

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“…The motility of the upper gastrointestinal tract in turn has an effect on gallbladder motility [29, 30]which is of unquestionable importance in the pathogenesis of gallstones. Furthermore, upper gastrointestinal motility influences small intestinal microecology [31], and a change in the microecology has been described in patients with duodenal diverticula [13]. …”

Section: Discussionmentioning

confidence: 99%

Structure and Composition of Common Bile Duct Stones in Relation to Duodenal Diverticula, Gastric Resection, Cholecystectomy and Infection

Sandstad¹,

Osnes²,

Skar³

et al. 2000

Digestion

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Background: Common bile duct stones represent a clinical problem often involving severe infection, cholangitis and cholestasis. Stasis and infection are thought to play a part in the pathogenesis of choledocholithiasis. Investigations on the etiology of common bile duct stones are, however, scarce because of the difficult access to common bile duct stones and bile. In a clinical series of common bile duct stones, we studied the gross appearance of stones extracted endoscopically from the common bile duct and measured the cholesterol and bilirubinate content in order to elucidate factors of importance to etiology. Methods: In 135 patients treated endoscopically for bile duct stones, the stones or parts of the stones were collected. Appearances of the cut surface of the stones were studied and described. Cholesterol and bilirubinate content were analyzed enzymatically and with infrared spectroscopy. The growth in bile of gas-producing bacteria previously shown to be correlated with enterobacteriacea was investigated. Results: Seventy-five percent of the stones were pigment stones, the majority with concentric pigmented layering. There was good agreement between cholesterol measurements. With a cutoff at 50% for the infrared measurements and 25% for the enzymatic assay only 3 stones were discordant between cholesterol measurements and visual inspection. Twenty-one of 23 patients with a previous Billroth-II gastric resection had pigment stones (p < 0.05). Gas-producing bacteria were significantly more prevalent in the bile from patients with layered pigment stones. Conclusion: Pigment stones with concentric layering highly suggestive of a cyclic process of crystallization were recovered from the common bile duct in 70% of the patients in our series.

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Abnormal intestinal motor patterns explain enteric colonization with gram-negative bacilli in late radiation enteropathy

Cited by 161 publications

References 57 publications

Radiation-induced small bowel disease: latest developments and clinical guidance

Radiation-induced small bowel disease: latest developments and clinical guidance

Sobrecrecimiento bacteriano intestinal: An update

Structure and Composition of Common Bile Duct Stones in Relation to Duodenal Diverticula, Gastric Resection, Cholecystectomy and Infection

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