2023
DOI: 10.3389/fnagi.2023.1132723
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Abnormal intra- and inter-network functional connectivity of brain networks in early-onset Parkinson’s disease and late-onset Parkinson’s disease

Abstract: ObjectiveThe purpose of this study is to look into the altered functional connectivity of brain networks in Early-Onset Parkinson’s Disease (EOPD) and Late-Onset Parkinson’s Disease (LOPD), as well as their relationship to clinical symptoms.MethodsA total of 50 patients with Parkinson’ disease (28 EOPD and 22 LOPD) and 49 healthy controls (25 Young Controls and 24 Old Controls) were admitted to our study. Employing independent component analysis, we constructed the brain networks of EOPD and Young Controls, LO… Show more

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Cited by 5 publications
(3 citation statements)
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“…This finding is supported by previous functional network study as well [48]. Increased functional connectivity in PoCG was negatively correlated with UPDRS-III scores in early-onset PD, possibly as a compensatory response to motor impairments [48]. Similarly, in our study, the increase of BC at left PoCG may also be a compensatory response to decrease of DC at left ROL, especially considering that ROL connects precentral and postcentral gyri [44].…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…This finding is supported by previous functional network study as well [48]. Increased functional connectivity in PoCG was negatively correlated with UPDRS-III scores in early-onset PD, possibly as a compensatory response to motor impairments [48]. Similarly, in our study, the increase of BC at left PoCG may also be a compensatory response to decrease of DC at left ROL, especially considering that ROL connects precentral and postcentral gyri [44].…”
Section: Discussionsupporting
confidence: 91%
“…Increase of BC at left PoCG in PD patients with VBD suggests relatively increased importance of PoCG in facilitating information flow and bridging disparate parts [17]. This finding is supported by previous functional network study as well [48]. Increased functional connectivity in PoCG was negatively correlated with UPDRS-III scores in early-onset PD, possibly as a compensatory response to motor impairments [48].…”
Section: Discussionsupporting
confidence: 76%
“…It can also be used to assess neuronal activation and/or intrinsic activity patterns by leveraging the paramagnetic properties of blood. In patients with PD, fMRI investigations have identified and validated disrupted functional connectivity ( 6 ) in the striatal, limbic, and parietal regions ( 7 , 8 ), as well as significant effects on the sensorimotor network (SMN) ( 5 , 9 ), basal ganglia network (BGN) ( 5 ), executive control network (ECN) ( 7 ), frontal-striatal network ( 10 , 11 ), and default mode network (DMN) ( 12 ). Alterations in the motor-related brain network can elucidate the motor symptoms associated with dopamine in PD patients.…”
Section: Introductionmentioning
confidence: 99%