Abnormal involuntary movements in patients on long-acting neuroleptics

Oyewumi, L. Kola; Lapierre, Yvon D.; Gray, Richard W.; Batth, S.; Gelfand, Ronald

doi:10.1016/0278-5846(83)90052-0

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Traditional neuroleptics are known to induce parkinsonism in 2060 % of treated patients (Baldessarini et al 1980;Oyewumi et al 1983;Tarsey 1983). Neuroleptics with combined dopaminergic-serotoninergic action tend to be superior to typical neuroleptics in the treatment of secondary negative symptoms, while producing less parkinsonism (Borison 1995).…”

Section: Discussionmentioning

confidence: 98%

“…Traditional neuroleptics are antidopaminergic drugs with powerful antipsychotic e¤ects on positive symptoms such as delusions and hallucinations, but their use has several limitations. Their administration in schizophrenia may induce secondary negative symptoms that bear a remarkable similarity to deÞcit symptoms (Schooler 1994) or produce extrapyramidal side e¤ects in a high proportion of treated patients (Baldessarini et al 1980;Oyewumi et al 1983;Tarsey 1983). Neuroleptic-induced extrapyramidal symptoms may be caused by greater than 85 % absolute occupancy of D 2 receptors in the striatum (Farde et al 1992;Bench et al 1993).…”

Section: Introductionmentioning

confidence: 98%

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Improvement of acute exacerbations of schizophrenia with amisulpride: a comparison with haloperidol

et al. 1997

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Amisulpride is a substituted benzamide with high selectivity for dopaminergic D2 and D3 receptors. This study compared 800 mg/day amisulpride and 20 mg/day haloperidol in patients with acute exacerbations of schizophrenia. This multicenter, double-blind trial involved 191 patients allocated, after a 1 to 7-day wash-out period, to amisulpride (n = 95) or haloperidol (n = 96) for 6 weeks. Improvement of mean BPRS total score was 48% for amisulpride and 38% for haloperidol (NS), whereas improvement in the Negative PANSS subscale was greater in the amisulpride group (37%) compared to haloperidol (24%) (P = 0.038). CGI scores showed a higher number of responders in the amisulpride (62%) than in the haloperidol group (44%) (P = 0.014). More extrapyramidal symptoms measured with the Simpson-Angus scale were provoked in the haloperidol group (P = 0.0009). Amisulpride is at least as effective as haloperidol in the treatment of acute exacerbations of schizophrenia, and is more effective in the treatment of negative symptoms whilst causing less parkinsonism.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Improvement of acute exacerbations of schizophrenia with amisulpride: a comparison with haloperidol

et al. 1997

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“…Several investigators have noted a significant inverse correlation between the severity of dyskinesia and depressive symptomatology (Vogel 1982; Oyewumi et al 1983). Wilson et al (1983) proposed that the insidious intrusion of affective symptomatology in chronic medicated schizophrenics is a behavioral equivalent of tardive dyskinesia, which they provocatively christened “tardive dysmentia.”…”

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confidence: 99%

Anosognosia in Tardive Dyskinesia: "Tardive Dysmentia" or "Tardive Dementia"?

Myslobodsky

1986

Schizophrenia Bulletin

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Wilson et al. (1983) called attention to the increasing incidence of affective symptomatology in schizophrenic patients on chronic neuroleptic medication. They designated the emerging syndrome as tardive dysmentia in order to emphasize its connection with the pathophysiology of tardive dyskinesia. The present contribution suggests that the emotional indifference or frank anosognosia of abnormal involuntary movements noted in the great majority (95 percent) of patients with tardive dyskinesia is another possible feature of tardive dysmentia. An attempt was made to explain anosognosia, and some difficulties that mar interpretation of data were pointed out. Anosognosia was proposed to represent a symptom related to some sort of cognitive disorder accompanying tardive dyskinesia, at least in the elderly. It was suggested that dementia may be associated with a predominant impairment of dopaminergic circuitry in the right cerebral hemisphere.

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