2015
DOI: 10.3748/wjg.v21.i22.7059
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Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review

Abstract: Visceral myopathy is one of the causes of chronic intestinal pseudo-obstruction. Most cases pathologically reveal degenerative changes of myocytes or muscularis propia atrophy and fibrosis. Abnormal layering of muscularis propria is extremely rare. We report a case of a 9-mo-old Thai male baby who presented with chronic intestinal pseudo-obstruction. Histologic findings showed abnormal layering of small intestinal muscularis propria with an additional oblique layer and aberrant muscularization in serosa. The p… Show more

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Cited by 7 publications
(5 citation statements)
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“…Collection of gut full‐thickness biopsies is aimed at providing clinicians with a histopathological correlate which may unravel abnormalities related to: (i) extrinsic and/or intrinsic neurons controlling gut functions; (ii) the ICC networks; and (iii) enteric smooth muscle cells. Changes affecting these cellular systems are tightly linked to the pathophysiology of CIPO and may have prognostic and sometimes therapeutic implications . Minimally invasive procedures, e.g.…”
Section: Diagnosismentioning
confidence: 99%
See 1 more Smart Citation
“…Collection of gut full‐thickness biopsies is aimed at providing clinicians with a histopathological correlate which may unravel abnormalities related to: (i) extrinsic and/or intrinsic neurons controlling gut functions; (ii) the ICC networks; and (iii) enteric smooth muscle cells. Changes affecting these cellular systems are tightly linked to the pathophysiology of CIPO and may have prognostic and sometimes therapeutic implications . Minimally invasive procedures, e.g.…”
Section: Diagnosismentioning
confidence: 99%
“…Collection of gut full-thickness biopsies is aimed at providing clinicians with a histopathological correlate which may unravel abnormalities therapeutic implications. 88,89 Minimally invasive procedures, e.g. laparoscopic surgery or -very recently -endoscopic approaches (for example natural-orifice translumenal endoscopic surgery), have shown a high diagnostic yield and safety.…”
Section: Histopathologymentioning
confidence: 99%
“…VM may be classified as inherited, primary idiopathic, or secondary to other etiologies (Table 1). 8 Intestinal involvement may range from malrotations, microcolon (neonates), and CIPO (all ages) to a more severe form, namely, megacystis-microcolon-intestinal hypoperistalsis syndrome. The pathogenic mechanism of VM includes missense mutations of genes such as ACTG2 and MYH11 leading to the synthesis of abnormal proteins, which are hypothesized to affect the polymerization of actin filaments thereby affecting smooth muscle contraction.…”
Section: Discussionmentioning
confidence: 99%
“…Intestinal myopathies are characterized by diffuse abnormalities in the muscular layering and supernumerary intestinal muscle coat. Intestinal mesenchymopathies involve abnormalities of interstitial Cajal cells and collagenous tissues of the muscularis propria [10][11][12][13][14] .…”
Section: Introductionmentioning
confidence: 99%