Abnormal left ventricular filling in patients with sustained myocardial relaxation: Assessment of diastolic parameters using radionuclide angiography and echocardiography

Abstract

Summary:Parameters of left ventricular filling obtained from time-activity curves of radionuclide angiograms were compared with parameters of myocardial relaxation from digitized M-mode curves of the free wall endocardium in 25 consecutive patients. Eight patients had normal left ventricular systolic and diastolic function. Five patients with low ejection fraction (EF < 50%) also had abnormal values of peak filling rate (PFR), time to peak filling rate (Tr), and/or time constant of endocardial retraction (Te). Twelve patients with normal EF had three (40%), two (40%), or one (20%) of the diastolic parameters within the pathological range. Tr correlated significantly with Te (r=0.88, p<O.OOl), and patients with Te prolongation always had high values of Tr. One of the diastolic parameters (PFR) correlated significantly with EF (r=0.60, p ~0 . 0 1 ) .Parameters of left ventricular filling and myocardial relaxation are thus abnormal in many patients with normal systolic function, indicating that diastolic parameters may be more sensitive to myocardial deterioration.

Noninvasive findings in patients with hypertrophic and dilative cardiomyopathy: A combined echocardiographic and radionuclide angiographic study

“…The method was previously described (Bryhn, 1984b) and the time-activity curve analysis was performed according to the report of Bacharach ef al. (1979).…”

“…1) is the time interval between end-systole and the point on the timeactivity curve where maximum counts enters the LV-ROI. Tr, which is independent of background activity, is correlated to the duration of myocardial relaxation (Bryhn, 1984b). Normal values were taken from the comprehensive material of Bonow et al (1981a) where Tr was 136+22 ms.…”

“…The instantaneous LV dimension curve gives approximate information about the LV filling profile (Gibson and Brown, 1983). Examination exclusively of the free wall endocardium gives information about the myocardial activity and thus parameters of myocardial relaxation may be provided (Bryhn, 1984b).…”

Left ventricular diastolic and systolic function during isometric exercise: An echocardiographic study

“…2 ; Bryhn, 1984b). The first derivative of this M-mode curve defines a point of end-systole and curves.…”

“…however, changed significantly in the present r W n . Thesc parameters may be more sensitive to mywardial dysfunction (Bryhn, 1984b) and undoubtedly the IAol11ctric handgrip test provides useful information about col11pletc myocardial response during work including Lv systolic and diastolic performance.…”