Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors

Sun, Dong; Zhang, Junjian; Yang, Fan; Liu, Xuan; Gao, Yong-Zhe; Wu, Guangyao; Yan, Yatao; Zeng, Junjie

doi:10.1093/ageing/afu027

Cited by 12 publications

(11 citation statements)

References 30 publications

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“…Abnormality of these signals had been demonstrated in a number of central nervous system diseases [ 19 , 20 ]. Similar to our previous study [ 13 ], we found that aCAS patients had lower NAA/Cr ratio in the left hippocampus.…”

Section: Discussionsupporting

confidence: 92%

“…Since previous study had demonstrated that abnormal level of hippocampus metabolites may mediate cognitive performance, we selected 4–6 voxels from both hippocampi using workstation Spectroscopy software [ 13 ]. Then the concentrations of N -acetyl-aspartate (2.02 ppm), choline (3.22 ppm), creatine (3.02 ppm), the ratio of NAA/Cr, and the ratio of Cho/Cr were measured in each selected voxel.…”

Section: Methodsmentioning

confidence: 99%

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Impairments in Brain Perfusion, Metabolites, Functional Connectivity, and Cognition in Severe Asymptomatic Carotid Stenosis Patients: An Integrated MRI Study

Wang

Xiao

et al. 2017

Neural Plasticity

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Carotid artery stenosis without transient ischemic attack (TIA) or stroke is considered as “asymptomatic.” However, recent studies have demonstrated that these asymptomatic carotid artery stenosis (aCAS) patients had cognitive impairment in tests of executive function, psychomotor speed, and memory, indicating that “asymptomatic” carotid stenosis may not be truly asymptomatic. In this study, when 19 aCAS patients compared with 24 healthy controls, aCAS patients showed significantly poorer performance on global cognition, memory, and executive function. By utilizing an integrated MRI including pulsed arterial spin labeling (pASL) MRI, Proton MR Spectroscopy (MRS), and resting-state functional MRI (R-fMRI), we also found that aCAS patients suffered decreased cerebral blood flow (CBF) mainly in the Left Frontal Gyrus and had decreased NAA/Cr ratio in the left hippocampus and decreased connectivity to the posterior cingulate cortex (PCC) in the anterior part of default mode network (DMN).

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Impairments in Brain Perfusion, Metabolites, Functional Connectivity, and Cognition in Severe Asymptomatic Carotid Stenosis Patients: An Integrated MRI Study

Wang

Xiao

et al. 2017

Neural Plasticity

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“…VRFs could function alone or together to affect cognitive performance. Our previous work has shown that, with the aggregation of VRFs, old stroke‐free adults demonstrated worse cognitive performance and more abnormal concentrations of brain metabolites in the hippocampus . This may also apply to the young adults group.…”

Section: Discussionmentioning

confidence: 90%

Vascular risk factors aggravate cognitive impairment in first‐ever young ischaemic stroke patients

Ren

Zhang

et al. 2016

Euro J of Neurology

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“…In high levels of VRFs burden, the prefrontal N-acetylaspartate/creatine (NAA/Cr) ratios were markedly lower than the low-risk individuals. This was associated with executive function via a magnetic resonance spectroscopy (MRS) study (Sun et al, 2014 ). The mitochondrial morphological abnormalities that were attributed to oxidative stress were identified in the DLPFC, where mRNA of mitochondrial proteins was expressed intensively, as vital part of the AD progression (Ansari and Scheff, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

The Dose-Dependent Effects of Vascular Risk Factors on Dynamic Compensatory Neural Processes in Mild Cognitive Impairment

Chen

et al. 2018

Front. Aging Neurosci.

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Background/Objectives: Mild cognitive impairment (MCI) has been associated with risk for Alzheimer's Disease (AD). Previous investigations have suggested that vascular risk factors (VRFs) were associated with cognitive decline and AD pathogenesis, and the intervention of VRFs may be a possible way to prevent dementia. However, in MCI, little is known about the potential impacts of VRFs on neural networks and their neural substrates, which may be a neuroimaging biomarker of the disease progression.Methods: 128 elderly Han Chinese participants (67 MCI subjects and 61 matched normal elderly) with or without VRFs (hypertension, diabetes mellitus, hypercholesterolemia, smoking and alcohol drinking) underwent the resting-state functional magnetic resonance imaging (fMRI) and neuropsychological tests. We obtained the default mode network (DMN) to identify alterations in MCI with the varying number of the VRF and analyzed the significant correlation with behavioral performance.Results: The effects of VRF on the DMN were primarily in bilateral dorsolateral prefrontal cortex (DLPFC) (i.e., middle frontal gyrus). Normal elderly showed the gradually increased functional activity of DLPFC, while a fluctuant activation of DLPFC was displayed in MCI with the growing number of the VRF. Interestingly, the left DLPFC further displayed significantly dynamic correlation with executive function as the variation of VRF loading. Initial level of compensation was observed in normal aging and none-vascular risk factor (NVRF) MCI, while these compensatory neural processes were suppressed in One-VRF MCI and were subsequently re-aroused in Over-One-VRF MCI.Conclusions: These findings suggested that the dose-dependent effects of VRF on DLPFC were highlighted in MCI, and the dynamic compensatory neural processes that fluctuated along with variations of VRF loading could be key role in the progression of MCI.

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Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors

Abstract: abnormal concentrations of brain metabolites and decreased glutamate plus glutamine concentration may play an important role in the pathophysiology of VRF-associated cognitive impairment. Brain metabolites detected by (1)H MRS may serve as important markers for monitoring VRFs burden.

Cited by 12 publications

References 30 publications

Impairments in Brain Perfusion, Metabolites, Functional Connectivity, and Cognition in Severe Asymptomatic Carotid Stenosis Patients: An Integrated MRI Study

Impairments in Brain Perfusion, Metabolites, Functional Connectivity, and Cognition in Severe Asymptomatic Carotid Stenosis Patients: An Integrated MRI Study

Vascular risk factors aggravate cognitive impairment in first‐ever young ischaemic stroke patients

The Dose-Dependent Effects of Vascular Risk Factors on Dynamic Compensatory Neural Processes in Mild Cognitive Impairment

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