Abnormal lipid profile and hyperinsulinaemia after a mixed meal: additional cardiovascular risk factors in young adults born preterm

Rotteveel, Joost; Weissenbruch, Mirjam M. van; Twisk, Jos W. R.; Waal, Henriëtte A. Delemarre-van de

doi:10.1007/s00125-008-1029-5

Cited by 30 publications

(27 citation statements)

References 23 publications

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“…In concordance with prior reports of association between premature birth and insulin resistance 45 , and other CVRF such as dyslipidemia and HBP 46 , we found a negative association between gestational age at birth and HBP or low HDLc. This highlights the great impact that conditions early in life may have on subsequent health, and deserves further exploration in future studies.…”

Section: Discussionsupporting

confidence: 92%

Cardiovascular risk factors and metabolic syndrome in a population of young students from the National University of Colombia

Feliciano-Alfonso¹,

Mendivil²,

Ariza³

et al. 2010

Rev. Assoc. Med. Bras.

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SummaryObjective. To estimate prevalence and distribution of cardiovascular risk factors and Metabolic Syndrome (MS) in young individuals admitted to the National University of Colombia in Bogotá.MethOds. An analytic cross-sectional study was conducted in a sample of 249 individuals of both genders aged 15 to 20 years. A questionnaire was personally administered to collect demographic, socioeconomic, smoking, perinatal, and women's health data. Anthropometric measurements, blood pressure, and a fasting blood sample were taken. Prevalence of MS was determined and compared using criteria from several qualified institutions. Results. We found a high prevalence of smoking (18.9%), arterial prehypertension (14.1%) and overweight (11.2%), 9.2% of study participants had prediabetes, and the most frequent dyslipidemia was low HDL cholesterol (13.3%). Alcoholic beverage consumption was declared by 60.6% of study participants. Body mass index was associated with significant increases in blood pressure, LDL cholesterol and plasma triglyceride levels. Gestational age at birth was inversely associated with presence of low HDL cholesterol levels and high blood pressure. Prevalence of the MS varied markedly according to the definition employed: 9.2% using REGODCI (Research Group on Diabetes and Chronic Illnesses) criteria, 2% using IDF (International Diabetes Federation) criteria, and 2.4% using AHA (American Heart Association) criteria. cOnclusiOn. The encountered prevalence of modifiable cardiovascular risk factors justifies promotion of therapeutic lifestyle changes among this age group in Colombia. Further harmonization of MS criteria in young individuals is needed. caRdiOvasculaR Risk factORs and MetabOlic syndROMe in a pOpulatiOn Of yOung students fROM the natiOnal univeRsity Of cOlOMbia jOhn edwin felicianO-alfOnsO 1* , caRlOs OliMpO Mendivil 2 , iván daRíO sieRRa aRiza 3 , claRa eugenia péRez 4 Study conducted at

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Section: Discussionsupporting

confidence: 92%

Cardiovascular risk factors and metabolic syndrome in a population of young students from the National University of Colombia

Feliciano-Alfonso¹,

Mendivil²,

Ariza³

et al. 2010

Rev. Assoc. Med. Bras.

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“…Furthermore, studies involving measurement of lipids after a meal 12,45 or detailed lipid profiling by metabolomics 17 have indicated a more atherogenic lipid profile in adults born preterm.…”

Section: Figurementioning

confidence: 99%

“…At least those born smallest and most immature show as children and adults more pronounced cardiovascular risk factors, for example increased blood pressure (BP), [5][6][7][8][9][10][11][12][13][14][15][16][17] reduced glucose tolerance, 7,11 and increased insulin resistance, 7,8,18 compared with those born at term. As to plasma lipids, the results are mixed.…”

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confidence: 99%

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Cardiovascular Risk Factors in Adolescents Born Preterm

Sipola-Leppänen¹,

Vääräsmäki

Tikanmäki³

et al. 2014

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Adolescents and adults born early preterm have higher blood pressure and altered glucose metabolism compared with their term born peers. Evidence of an atherogenic lipid profile is inconsistent. Whether these risks apply to those born less preterm is not known. WHAT THIS STUDY ADDS:In adolescence, girls have higher blood pressure and boys a more atherogenic lipid profile than their term born peers. Overall, our results are consistent with a dose-response relationship between shorter length of gestation and increasing levels of cardiovascular risk factors. abstract BACKGROUND: Adolescents and adults born as small preterm infants show more pronounced risk factors of cardiovascular disease. Whether similar risks apply across all degrees of preterm birth is poorly known. METHODS:We studied the association between preterm birth and cardiovascular risk factors in 6642 16-year-old adolescents of the populationbased Northern Finland Birth Cohort 1986. Of these, 79 (1.2%) were born at ,34 gestational weeks (early preterm), 238 (3.6%) at 34 to 36 weeks (late preterm), and 6325 at term (controls).RESULTS: Girls born early preterm had 6.7 mm Hg (95% confidence interval: 3.1-10.2) higher systolic blood pressure (BP) and 3.5 mm Hg (1.1-5.8) higher diastolic BP, but no difference in serum lipid levels compared with control girls. Boys showed no differences in BP, but boys born early preterm had 6.7% (0.2%-13.7%) higher total cholesterol, 11.7% (2.1%-22.3%) higher low-density lipoprotein cholesterol, and 12.3% (3.1%-22.4%) higher apolipoprotein B concentrations. The differences were similar (BP) or stronger (lipids) when adjusted for maternal smoking, birth weight SD score, parental education, pubertal stage, BMI, and lifestyle. There were similar associations with length of gestation as a continuous variable. Accordingly, mean differences between late preterm and controls were in the same direction but weaker, although most were not statistically significant. CONCLUSIONS:Preterm birth was associated with elevated BP in adolescent girls and an atherogenic lipid profile in boys. Because these associations were strongest among those born early preterm, our findings are consistent with a dose-response relationship between shorter length of gestation and cardiovascular risk factors. Dr Sipola-Leppänen carried out initial analyses and drafted the initial manuscript; Drs Vääräsmäki and Kajantie carried out initial analyses, reviewed and revised the manuscript, and supervised the writing process; Drs Tikanmäki, Hovi, and Miettola reviewed and revised the manuscript; Drs Ruokonen, Pouta, and Järvelin coordinated and supervised data collection and critically reviewed the manuscript; and all authors approved the final manuscript as submitted.www.pediatrics.org/cgi

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“…12 Compared with term-born infants, as adults they have higher blood pressure 13,14 and are more likely to have glucose intolerance, 15 insulin resistance and dyslipidaemia. 16 Insulin resistance in prepubertal children born extremely preterm has been associated with neonatal nutrition. Preterm infants were found to be insulin resistant compared with term-born infants.…”

Section: Preterm Infantsmentioning

confidence: 99%

Nutritional Evaluation and Optimisation in Neonates (NEON) trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised double-blind controlled trial

et al. 2016

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Abnormal lipid profile and hyperinsulinaemia after a mixed meal: additional cardiovascular risk factors in young adults born preterm

Cited by 30 publications

References 23 publications

Cardiovascular risk factors and metabolic syndrome in a population of young students from the National University of Colombia

Cardiovascular risk factors and metabolic syndrome in a population of young students from the National University of Colombia

Cardiovascular Risk Factors in Adolescents Born Preterm

Nutritional Evaluation and Optimisation in Neonates (NEON) trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised double-blind controlled trial

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