Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis

Abstract

This study investigated lipid metabolism in broilers with spontaneous femoral head necrosis (FHN) by determining the levels of markers of the blood biochemistry and bone metabolism. The birds were divided into a normal group and FHN group according to the femoral head scores of 3-, 4-, and 5-week-old chickens with FHN, and a comparative study was conducted. The study showed that spontaneous FHN broilers had a lipid metabolism disorder, hyperlipidemia, and an accumulation of lipid droplets in the femur. In addition, there were significant changes in the bone parameters and blood bone biochemistry markers, and the expression of genes related to lipid metabolism in the femoral head was also significantly increased. Therefore, FHN may result from dyslipidemia, which affects the bone growth and development of broilers.

Impact of exogenous hydrogen peroxide on osteogenic differentiation of broiler chicken compact bones derived mesenchymal stem cells

“…The pathology of osteomyelitis is characterized by localized inflammation, bone mineral loss, and structural damage, which share similarities with broiler BCO ( Grbic et al, 2014 ). Furthermore, a recent study on femoral necrosis pathogenicity also reported an abnormal increased in lipid metabolism and decreases in bone formation in a chicken femoral head necrosis disease model ( Fan et al, 2021 ). Therefore, by gathering all the evidence above, we proposed that oxidative stress could potentially be a co-factor involved in chicken bone necrosis.…”

Genetic background of walking ability and its relationship with leg defects, mortality, and performance traits in turkeys (Meleagris gallopavo)

“…This influence on skeletal homeostasis is exerted through fatty acid oxidation in osteoblasts, the cells responsible for creating new bone and facilitating the growth and development of existing bones ( Alekos et al, 2020 ). Some studies have already reported the effect of lipid metabolism on bone growth and development in broiler chicks ( Watkins et al, 1997 ; Fan et al, 2021 ). This underscores the importance of lipid metabolism in bone health, as they may result in changes in bone homeostasis and an increase in osteopathy, such as osteoarthritis and fractures ( Wang et al, 2022 ).…”

Notch-RBPJ Pathway for the Differentiation of Bone Marrow Mesenchymal Stem Cells in Femoral Head Necrosis

“…As a bone disorder, FHN is characterized by periarticular bone disintegration and cartilage degeneration [ 22 ]. According to our previous study, FHN-affected broilers showed lipid metabolism disorders, increased lipid droplet formation, an imbalance in cartilage homeostasis, reduced extracellular matrix (ECM) formation, and simultaneous apoptosis [ 23 , 24 , 25 ]. Reduced osteogenic and chondrogenic differentiation of BMSCs in FHN-affected broilers and enhanced lipogenic differentiation were observed in the present study ( Figure 1 B).…”