Abnormal maternal behavior in mice lacking phospholipase Cβ1

Kim, Hea-jin; Jang, Jaewon; Koh, Hun Yeong

doi:10.1080/19768354.2022.2141319

Cited by 2 publications

(12 citation statements)

References 57 publications

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“…We consider dopamine as a strong candidate. Dopamine regulates reward, motivation, motor output, social behaviors and emotions (Berke 2018 ; Wise 2004 ; Kim et al 2022 ; Jung and Noh 2021 ). Additionally, it plays a pivotal role in interval timing.…”

Section: Discussionmentioning

confidence: 99%

Core clock gene, Bmal1 , is required for optimal second-level interval production

Kim,

Choe

2023

Animal Cells and Systems

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Perception and production of second-level temporal intervals are critical in several behavioral and cognitive processes, including adaptive anticipation, motor control, and social communication. These processes are impaired in several neurological and psychological disorders, such as Parkinson’s disease and attention-deficit hyperactivity disorder. Although evidence indicates that second-level interval timing exhibit circadian patterns, it remains unclear whether the core clock machinery controls the circadian pattern of interval timing. To investigate the role of core clock molecules in interval timing capacity, we devised a behavioral assay called the interval timing task to examine prospective motor interval timing ability. In this task, the mouse produces two separate nose pokes in a pretrained second-level interval to obtain a sucrose solution as a reward. We discovered that interval perception in wild-type mice displayed a circadian pattern, with the best performance observed during the late active phase. To investigate whether the core molecular clock is involved in the circadian control of interval timing, we employed Bmal1 knockout mice (BKO) in the interval timing task . The interval production of BKO did not display any difference between early and late active phase, without reaching the optimal interval production level observed in wild-type. In summary, we report that the core clock gene Bmal1 is required for the optimal performance of prospective motor timing typically observed during the late part of the active period.

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Section: Discussionmentioning

confidence: 99%

Core clock gene, Bmal1 , is required for optimal second-level interval production

Kim,

Choe

2023

Animal Cells and Systems

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“…The basic protocol was previously described (Kim et al 2022 ). Virgin females 15–20 weeks old (WT, N = 10; KO, N = 11) were mated with WT virgin males 20–30 weeks old to video-record the parental care behaviors of the two members from each pair.…”

Section: Methodsmentioning

confidence: 99%

“…The basic procedure of the pup retrieval test (PRT) was described previously (Kim et al 2022 ). Two groups of nine sires mated with either WT or KO dams were tested during the period within 12 h postpartum (PPH12) or after PPH 18 (PPH18).…”

Section: Methodsmentioning

confidence: 99%

“…Mouse fathers appear to have direct or indirect effects on pup survival (Barnett and Dickson 1985 ; Wright and Brown 2000 ), as well as on their partner’s maternal care behavior, indirectly affecting the physical and behavioral development of the litter (Mashoodh et al 2012 ; Korgan et al 2016 ; Korgan et al 2018 ). However, mouse mothers are generally self-sufficient to rear their young without partner contribution (Kim et al 2022 ) ( Figure 1 (A,B)). To investigate the paternal response to reduced partner care, the present study used mutant female mice as pup-neglecting mothers.…”

Section: Introductionmentioning

confidence: 99%

“…Phospholipase Cβ1 (PLCβ1) knockout (KO) dams care for their pups as well as wild-type (WT) dams during the maternal onset phase right after parturition. However, they neglect pups from about 18 h postpartum (PPH 18); thus, if left alone as a single parent without their mate, they lose all pups to death in 2–3 days after parturition (Kim et al 2022 ). We found that sires mated with a KO dam increase care effort to compensate for the lost maternal care in terms of both pup survival rate and total care to a comparable level to controls.…”

Section: Introductionmentioning

confidence: 99%

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Compensatory enhancement of paternal care in maternally neglected mice family

Jang,

Kim,

Koh

2023

Animal Cells and Systems

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Parental care strategies, ranging from biparental to uniparental, evolve based on factors affecting sexual conflict over care. Plasticity in how parents respond to reduction in each other’s care effort is thus proposed to be important in the evolution of parental care behaviors. Models predict that ‘obligate’ biparental care is stable when a parent responds to reduced partner effort with ‘partial’ compensation, trading-off current and future reproduction. A meta-analysis of experimental studies on biparental birds also revealed partial compensation, supporting coevolution of parental care type and plasticity pattern. However, few studies have addressed this issue across different taxa and different parental care types. In laboratory mice, a female-biased ‘facultative’ biparental species, fathers paired with a competent mother rarely provide care. We show that, when mated with a pup-neglecting mutant mother, fathers increased care effort to ‘fully’ compensate for the lost maternal care in both pup survival rate and total care amount. Pup retrieval latency was significantly shorter, and neural activity in relevant brain regions twice as high, suggesting enhanced motivation. This study with mice not only opens a road to explore the neural correlates of paternal plasticity but will also help understand how behavioral plasticity contributes to adaptive evolution of parental care behaviors.

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Abnormal maternal behavior in mice lacking phospholipase Cβ1

Cited by 2 publications

References 57 publications

Core clock gene, Bmal1 , is required for optimal second-level interval production

Core clock gene, Bmal1 , is required for optimal second-level interval production

Compensatory enhancement of paternal care in maternally neglected mice family

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