Abnormal maternal body mass index and obstetric and neonatal outcome

Galán, Sebastián Manzanares; Santalla, Hernández Angel; Vico, Zúñiga Irene; Criado, María Setefilla López; Pineda, Lloréns Alicia; Gallo, Vallejo José Luis

doi:10.3109/14767058.2011.575905

Cited by 61 publications

(31 citation statements)

References 24 publications

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“…However, the findings have not been consistent. Galan and colleagues, 19 in a retrospective cohort study, reported that women with class II or III obesity (BMI 35 or higher) were more likely to have an umbilical artery pH less than 7.10 than were normal-weight women (adjusted odds ratio 2.15, 95% CI 1.05-4.38). In contrast, Maisonneuve and colleagues, 20 in a case-control study, reported that cases (umbilical artery pH less than 7.00) were more likely to be obese (BMI 30 or higher) than controls, but the difference did not remain statistically significant in multivariate analysis.…”

Section: Discussionmentioning

confidence: 96%

“…There is no uniformly agreed-on threshold for defining acidemia. Although an arterial cord pH of 7.10 is approximately two standard deviations below the mean and others have used this threshold, 19 most neonates with values more extreme than even more restrictive thresholds (eg, arterial pH less than 7.00 or base deficit of more than 16 mmol/L) do not have complications associated with acidemia. Therefore, we refer to "adverse acid-base status" or "lower pH and higher base deficit" throughout the article rather than "acidemia."…”

Section: Methodsmentioning

confidence: 94%

“…19,20 Because labor abnormalities are more common in obese pregnant women, cesarean deliveries (both primary and repeat) are more common. The most common type of anesthesia for repeat (or other scheduled prelabor) cesarean deliveries is spinal anesthesia.…”

mentioning

confidence: 99%

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The Association of Maternal Obesity With Fetal pH and Base Deficit at Cesarean Delivery

Edwards

Cantu

Cliver

et al. 2013

Obstetrics &Amp; Gynecology

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Section: Discussionmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 94%

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The Association of Maternal Obesity With Fetal pH and Base Deficit at Cesarean Delivery

Edwards

Cantu

Cliver

et al. 2013

Obstetrics &Amp; Gynecology

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“…[52][53][54][55] Perhaps most relevant to our study is the association with fetal growth restriction. 19,56 In addition, obesity is linked to chronic illnesses 57,58 and social disadvantage, 59 which might affect the mother-infant interaction and the resources available to enhance the home environment.…”

Section: Discussionmentioning

confidence: 99%

Antenatal Antecedents of Cognitive Impairment at 24 Months In Extremely Low Gestational Age Newborns

2012

PEDIATRICS

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WHAT'S KNOWN ON THIS SUBJECT: Among extremely premature infants, survival has improved, but the rate of cognitive impairment has not. Impaired cognition is the most frequent developmental problem identified in survivors. Several antenatal factors have been associated with cognitive impairment, mostly related to social disadvantage. WHAT THIS STUDY ADDS:In addition to social disadvantage, antenatal characteristics associated with cognitive impairment include maternal obesity and thrombosis of fetal stem vessels. Prenatal infection and inflammation were not associated with impaired early cognitive function among extremely preterm infants. abstract BACKGROUND AND OBJECTIVES: Extremely low gestational age neonates are more likely than term infants to develop cognitive impairment. Few studies have addressed antenatal risk factors of this condition. We identified antenatal antecedents of cognitive impairment determined by the Mental Development Index (MDI) portion of the Bayley Scales of Infant Development, Second Edition (BSID-II), at 24 months corrected age. METHODS:We studied a multicenter cohort of 921 infants born before 28 weeks of gestation during 2002 to 2004 and assessed their placentas for histologic characteristics and microorganisms. The mother was interviewed and her medical record was reviewed. At 24 months adjusted age, children were assessed with BSID-II. Multinomial logistic models were used to estimate odds ratios. RESULTS:A total of 103 infants (11%) had an MDI ,55, and 99 infants (11%) had an MDI between 55 and 69. No associations were identified between organisms recovered from the placenta and developmental delay. Factors most strongly associated with MDI ,55 were thrombosis of fetal vessels (OR 3.1; 95% confidence interval [CI] 1.2, 7.7), maternal BMI .30 (OR 2.0; 95% CI 1.1, 3.5), maternal education #12 years (OR 3.4; 95% CI 1.9, 6.2), nonwhite race (OR 2.2; 95% CI 1.3, 3.8), birth weight z score , 22 (OR 2.8; 95% CI 1.1, 6.9), and male gender (OR 2.7; 95% CI 1.6, 4.5).CONCLUSIONS: Antenatal factors, including thrombosis of fetal vessels in the placenta, severe fetal growth restriction, and maternal obesity, convey information about the risk of cognitive impairment among extremely premature newborns. Pediatrics 2012;129:494-502

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“…To our knowledge, there are very few studies focusing on Mediterranean population and pregnancy outcome concerning offspring's death in obese pregnant women [12,30].…”

Section: Introductionmentioning

confidence: 98%

Prepregnancy maternal obesity and fetal-perinatal death in a Mediterranean country

Papachatzi

Papadopoulos

Dimitriou

et al. 2014

Journal of Perinatal Medicine

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Abnormal maternal body mass index and obstetric and neonatal outcome

Abstract: Severe or morbid obesity were associated with an increased risk of adverse perinatal outcome and mortality and should be managed as high-risk pregnancies.

Cited by 61 publications

References 24 publications

The Association of Maternal Obesity With Fetal pH and Base Deficit at Cesarean Delivery

The Association of Maternal Obesity With Fetal pH and Base Deficit at Cesarean Delivery

Antenatal Antecedents of Cognitive Impairment at 24 Months In Extremely Low Gestational Age Newborns

Prepregnancy maternal obesity and fetal-perinatal death in a Mediterranean country

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