Abnormal mitochondrial function and muscle wasting, but normal contractile efficiency, in haemodialysed patients studied non-invasively in vivo

Kemp, Graham J.; Crowe, Alex; Anijeet, Hameed; Gong, Qiyong; Bimson, William E.; Frostick, Simon P.; Bone, J. M.; Bell, G. H.; Roberts, Jeremy

doi:10.1093/ndt/gfh189

Cited by 62 publications

(57 citation statements)

References 18 publications

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“…Entretanto, representam forma de intervenção de complicações da doença renal (16) , visto que alterações na função pulmonar são comuns na disfunção renal (24) . Nos pacientes com IRA, a musculatura esquelética respiratória apresenta diminuição das propriedades de força, ocasionando déficit ventilatório, o que contribui para diminuição da capacidade pulmonar (27) . O uso de drogas vasoativas apresenta relação significante com o desenvolvimento de IRA, constituindo fator intensamente negativo.…”

Section: Discussionunclassified

Incidência E Fatores Predisponentes De Insuficiência Renal Aguda Em Unidade De Terapia Intensiva

et al. 2017

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INCIDENCE AND RISK FACTORS ASSOCIATED WITH ACUTE KIDNEY INJURY IN INTENSIVE CARE UNIT ABSTRACT:The study aims to identify the incidence, classification and risk factors for acute kidney injury in patients admitted to an intensive care unit. Descriptive documentary study with a quantitative approach, conducted from January to February 2016, based on the analysis of 114 medical records of hospitalized patients. The diagnosis was based on the criterion of the Acute Dialysis Quality Initiative. Incidence and the classification of acute kidney injury were assessed. Also, correlation was assessed using the Chi-square test (p<0.05) and Prevalence Ratio (p<0.05). The incidence rate of the disease is 44.7% (51 patients). Of these, most were at the risk class: 41% (20 patients).The development of disease is associated with changes in blood pressure levels, body fluid balance, inability of the kidneys to produce sufficient amounts of urine, and elevated blood urea and creatinine levels, and when complicated by the occurrence of acute respiratory diseases, mortality increases substantially. Strict monitoring of the identified factors is necessary, aiming at the early detection of acute kidney injury and decrease in mortality rates.

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Section: Discussionunclassified

Incidência E Fatores Predisponentes De Insuficiência Renal Aguda Em Unidade De Terapia Intensiva

et al. 2017

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“…Of the remaining case-control studies, seven 15,[36][37][38][39][40][41] included participants with chronic renal disease not on HD and with comorbidities (clinical evidence of polyneuropathy, varying degrees of paresis, myopathy, renal bone disease, cerebrovascular accident, diabetes mellitus, peripheral vascular disease, etc. ); four included male participants only; [42][43][44][45] and five [46][47][48][49][50] did not provide adequate description of the participants included in the study. Inclusion of participants with clinical evidence of neuromuscular involvement, wide age ranges, and comorbidities that could contribute to neuromuscular impairment suggested possible selection bias that could confound the outcomes of these studies.…”

Section: Methodological Qualitymentioning

confidence: 99%

“…The finding of myopathic changes in another sub-group by Blank et al 61 is supported by similar findings in two studies 46,48 that did not suggest (implicitly or otherwise) the presence of muscle weakness in their participants. 43,47 investigated the finger flexors. Specific differences among these four studies could not be clearly identified to establish why the cytosolic Pi was comparable to controls; they investigated the same muscles (calf and finger flexors) as the group of studies reporting increased cytosolic Pi, with the exception of the dorsiflexor muscle.…”

Section: Electrophysiological Characteristicsmentioning

confidence: 99%

Morphological, Electrophysiological, and Metabolic Characteristics of Skeletal Muscle in People with End-Stage Renal Disease: A Critical Review

Sawant¹,

Garland²,

House³

et al. 2011

Physiotherapy Canada

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Purpose: Fatigue is one of the most frequent debilitating symptoms reported by people with end-stage renal disease (ESRD) on haemodialysis (HD) therapy. A wide range of underlying abnormalities, including skeletal muscle weakness, have been implicated as causes of this fatigue. Skeletal muscle weakness is well established in this population, and such muscle weakness is amenable to physical therapy treatment. The purpose of this review was to identify morphological, electrophysiological, and metabolic characteristics of skeletal muscles in people with ESRD/HD that may cause skeletal muscle weakness. Method: Electronic databases were searched for relevant literature from inception to March 2010. Inclusion criteria were English language; adult subjects with ESRD/HD; and the use of muscle biopsy, electromyography, and nuclear magnetic spectroscopy ( 31 P-NMRS) techniques to evaluate muscle characteristics. Results: In total, 38 studies were included. All studies of morphological characteristics reported type II fibre atrophy. Electrophysiological characteristics included both neuropathic and myopathic skeletal muscle changes. Studies of metabolic characteristics revealed higher cytosolic inorganic phosphate levels and reduced effective muscle mass. Conclusion:The results indicate an array of changes in the morphological, electrophysiological, and metabolic characteristics of skeletal muscle structure in people with ESRD/HD that may lead to muscle weakness. RÉ SUMÉObjectif : La fatigue est l'un des symptô mes dé bilitants signalé s chez les personnes aux prises avec une insuffisance ré nale chronique au stade ultime avec l'hé modialyse (IRSU/HD). Un large é ventail d'anomalies sous-jacentes, y compris de la faiblesse du muscle squelettique, ont é té mises en cause dans cette fatigue. La faiblesse du muscle squelettique est courante au sein de cette population; une telle faiblesse musculaire peut faire l'objet de traitements en physiothé rapie. L'objectif de cette analyse é tait d'identifier les caracté ristiques morphologiques, é lectrophysiologiques et mé taboliques des muscles squelettiques qui pourraient susciter une faiblesse du muscle squelettique chez les personnes avec IRSU/HD. Mé thode : Une recherche a é té ré alisé e dans les bases de donné es é lectroniques de leur cré ation à mars 2010 afin de ré pertorier la documentation pertinente. Les critè res d'inclusion é taient que ces documents soient en anglais, qu'ils concernent des adultes avec IRSU/HD et que des techniques de biopsie musculaire, d'é lectromyographie et de spectroscopie magné tique nuclé aire ( 31 P-NMRS) avaient é té utilisé es pour é valuer les caracté ristiques des muscles concerné s. Ré sultats : Au total, 38 documents ont é té ré pertorié s et utilisé s. Toutes les é tudes des caracté ristiques morphologiques faisaient é tat d'atrophie des fibres de type II. Les caracté ristiques é lectrophysiologiques incluaient à la fois les changements né vropathiques et myopathiques. Les é tudes des caracté ristiques mé taboliques ont ré vé l...

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“…Some authors 10 who have studied the involvement of uremia in the diaphragm have concluded that loss of strength occurs through severe uremia. The ventilatory deficit due to this impairment in respiratory muscles, combined with other lung tissue impairments, compromises the functioning of this system, thereby contributing towards decreased lung capacity 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

Cury¹,

Brunetto²,

Aydos

2010

Rev. bras. fisioter.

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Objective: To evaluate lung function and functional capacity in patients with chronic kidney failure (CKF) undergoing dialysis and in patients after kidney transplant. Methods: Seventy-two participants were evaluated: 32 patients with CKF on dialysis (DG) for at least six months, ten patients who had kidney transplants (TG) at least six months earlier, and 30 healthy subjects as a control group (CG). all groups were evaluated using spirometry, with maximum inspiratory pressure (mIP) and maximum expiratory pressure (mEP), and using the six-minute walking test (6mWT). The SPSS 12.0 software was used for statistical analysis, with a minimum significance level of α<0.05. Results: There was a decreased lung function in the DG for FVC, FEV1, mVV, VC, mIP and mEP, and decreased FEV1 and mVV in the TG compared to the CG (one-way aNOVa/Fisher's post-hoc; p<0.01). There was also an association (chi-square) between decreased mIP and belonging to the DG ‫,5.0=ג(‬ p<0.001), between lower performance in the 6mWT for the DG and TG (p<0.01) compared to the CG (one-way aNOVa/Fisher's post-hoc), and between mIP and mEP (Pearson's coefficient; r=0.752; p<0.01). Conclusions:Patients with CKF undergoing dialysis showed impaired functional capacity and lung function that were not completely reverted in the kidney transplant patients.Key words: dialysis; kidney transplant; spirometry; respiratory muscles; functional capacity. ResumoObjetivo: avaliar a função pulmonar e a capacidade funcional em pacientes com insuficiência renal crônica (IRC) em hemodiálise e em pacientes após transplante renal. Métodos: Foram avaliados 72 indivíduos, sendo 32 pacientes com IRC em hemodiálise (GD) há mais de 6 meses, 10 pacientes transplantados renais (GT) há, pelo menos, 6 meses e 30 sujeitos saudáveis para grupo controle (GC). Todos os grupos foram avaliados utilizando espirometria, pressões inspiratória (PImax) e expiratória (PEmax) máximas e teste da caminhada em seis minutos (TC6min). Para análise estatística, foi utilizado o programa SPSS 12.0, com nível mínimo de significância α<0,05. Resultados: Foram encontrados resultados estatisticamente significativos (p<0,01) para: diminuição da função pulmonar no GD para Capacidade vital forçada (CVF), Volume expirado forçado (VEF1), Ventilação voluntária máxima (VVm), Capacidade vital (CV), PImax, PEmax e, para o GT, diminuição do VEF1 e VVm, quando comparados ao GC (aNOVa uma via/post hoc Fischer); associação (qui-quadrado) entre diminuição da PImax e pertencer ao GD ‫,5,0=ג(‬ p<0,001); menor desempenho no TC6min no GD e GT (p<0,01) quando comparados ao GC (aNOVa uma via/post hoc Fischer). Encontrou-se correlação significativa (coeficiente de Pearson) entre PImax e PEmax (r=0,752, P<0,01). Conclusões: Pode-se concluir que existem alterações na capacidade funcional e na função pulmonar do paciente com IRC em hemodiálise, as quais são indicativas de prejuízos funcionais que não se apresentam completamente revertidos no paciente transplantado renal.

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Abnormal mitochondrial function and muscle wasting, but normal contractile efficiency, in haemodialysed patients studied non-invasively in vivo

Cited by 62 publications

References 18 publications

Incidência E Fatores Predisponentes De Insuficiência Renal Aguda Em Unidade De Terapia Intensiva

Incidência E Fatores Predisponentes De Insuficiência Renal Aguda Em Unidade De Terapia Intensiva

Morphological, Electrophysiological, and Metabolic Characteristics of Skeletal Muscle in People with End-Stage Renal Disease: A Critical Review

Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

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