Abnormal Myocardial Enzymes are Important Indicators of Poor Prognosis in COVID-19 Patients

Abstract

Objective: Researching the prognostic value of myocardial enzymes in COVID-19 patients. Materials & methods: We collected 113 confirmed COVID-19 patients. The dynamic changes of CK, LDH and α-HBDH in patients were studied retrospectively, the correlation between myocardial enzyme index, clinical classification and outcome of patients and its significance to prognosis. Results: There are significant statistical differences between LDH, α-HBDH, CK and the clinical classification, and patient’s outcome. In the receiver operating characteristic curve analysis, LDH, α-HBDH and CK have a good diagnostic value for the death outcome of patients. Conclusion: LDH, α-HBDH and CK were the components of myocardial enzyme profiles, and our results found that they were significantly positively correlated with clinical classification and prognosis of COVID-19 patients. The values of LDH, α-HBDH and CK increased with the increase of the severity of admission clinical classification and the deterioration of outcome. Therefore, we propose that continuous monitoring of LDH, α-HBDH and CK indicators can warn the deterioration of COVID-19 to a certain extent, regardless of whether patients with cardiovascular diseases are combined or not, and prompt early intervention.

Serum hydroxybutyrate dehydrogenase and COVID-19 severity and mortality: a systematic review and meta-analysis with meta-regression

“…Nineteen studies were retrospective [ 38 , 39 , 41 – 47 , 49 – 55 , 57 – 59 ], whilst the remaining three did not report the study design [ 40 , 48 , 56 ]. Clinical endpoints included disease severity based on current clinical guidelines (13 studies) [ 39 , 41 , 43 , 45 – 48 , 50 – 52 , 55 , 59 ], disease progress (two studies) [ 40 , 56 ], occurrence of ARDS (one study) [ 54 ], and survival (six studies) [ 38 , 42 , 44 , 49 , 57 , 58 ]. In all studies, serum HBDH concentrations were measured on admission.…”

“…The risk of bias was considered to be low in 19 studies [ 38 – 40 , 42 – 46 , 48 – 50 , 52 – 59 ], and moderate in the remaining three [ 41 , 47 , 51 ].…”