Abnormal neural responses to emotional visual stimuli in adolescents with conduct disorder

Sterzer, Philipp; Stadler, Christina; Krebs, Annette; Kleinschmidt, Andreas; Poustka, Fritz

doi:10.1016/j.biopsych.2004.10.008

Cited by 282 publications

(255 citation statements)

References 59 publications

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“…Faster RTs in the provoking condition indicate that participants made a larger effort in the belief that they might avoid the aversive punishment (although the chance of winning was 50%). Attenuation of dACC/dmPFC activity in the provoking condition that elicited increased aggression is consistent with dACC dysfunction in aggressive populations (Sterzer et al, 2005;Meyer-Lindenberg et al, 2006;Aharoni et al, 2013).…”

Section: Discussionsupporting

confidence: 65%

“…Accordingly, alcohol-induced impairment of inhibitory control has been related to diminished activity of the lateral PFC (Kareken et al, 2013;Gan et al, 2014) and anterior cingulate cortex (ACC) under alcohol (Anderson et al, 2011). Aggressive behavior has also been linked to PFC hypo-activation, especially in the dorsal (d) ACC (Sterzer et al, 2005;Meyer-Lindenberg et al, 2006;Aharoni et al, 2013), and to increased activation of the amygdala, in particular for impulsive aggression triggered by provocation or threat, also referred to as reactive aggression (Meyer-Lindenberg et al, 2006;Coccaro et al, 2007). Reduced functional PFC-amygdala coupling under alcohol (Gorka et al, 2013) further suggests that alcohol-induced aggression might be mediated by impaired PFC functioning under alcohol, which might indirectly increase activation of the amygdala (Heinz et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation

Gan

Sterzer

Marxen

et al. 2015

Neuropsychopharmacol

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Although alcohol consumption is linked to increased aggression, its neural correlates have not directly been studied in humans so far. Based on a comprehensive neurobiological model of alcohol-induced aggression, we hypothesized that alcohol-induced aggression would go along with increased amygdala and ventral striatum reactivity and impaired functioning of the prefrontal cortex (PFC) under alcohol. We measured neural and behavioral correlates of alcohol-induced aggression in a provoking vs non-provoking condition with a variant of the Taylor aggression paradigm (TAP) allowing to differentiate between reactive (provoked) and proactive (unprovoked) aggression. In a placebo-controlled cross-over design with moderate alcohol intoxication (~0.6 g/kg), 35 young healthy adults performed the TAP during functional magnetic resonance imaging (fMRI). Analyses revealed that provoking vs non-provoking conditions and alcohol vs placebo increased aggression and decreased brain responses in the anterior cingulate cortex/dorso-medial PFC (provokingonon-provoking) and the ventral striatum (alcoholoplacebo) across our healthy sample. Interestingly, alcohol specifically increased proactive (unprovoked) but not reactive (provoked) aggression (alcohol × provocation interaction). However, investigation of inter-individual differences revealed (1) that pronounced alcohol-induced proactive aggression was linked to higher levels of aggression under placebo, and (2) that pronounced alcohol-induced reactive aggression was related to increased amygdala and ventral striatum reactivity under alcohol, providing evidence for their role in human alcohol-induced reactive aggression. Our findings suggest that in healthy young adults a liability for alcohol-induced aggression in a non-provoking context might depend on overall high levels of aggression, but on alcohol-induced increased striatal and amygdala reactivity when triggered by provocation.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation

Gan

Sterzer

Marxen

et al. 2015

Neuropsychopharmacol

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“…Stertzer et al reported reduced activation in the left amygdala of children with severe CD when viewing these pictures, although this result became significant only when they corrected for the influence of anxiety and depressive symptoms (Sterzer et al, 2005). It is also worth noting that an unusual deactivation of the right dorsal anterior cingulate cortex was observed in these patients during viewing of negative pictures, which may relate to their difficulties in regulating emotional behavior.…”

Section: Is the Amygdala Dysfunctional In Early-onsetmentioning

confidence: 95%

The evidence for a neurobiological model of childhood antisocial behavior.

Goozen¹,

Fairchild²,

Snoek³

et al. 2007

Psychological Bulletin

414

393

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Children with persistent antisocial and aggressive behavior are diagnosed as having disruptive behavior disorder. The authors review evidence that antisocial children, and especially those who persist with this behavior as they grow older, have a range of neurobiological characteristics. It is argued that serotonergic functioning and stress-regulating mechanisms are important in explaining individual differences in antisocial behavior. Moreover, low fear of punishment and physiological underactivity may predispose antisocial individuals to seek out stimulation or take risks and may help to explain poor conditioning and socialization. The authors propose a theoretical model highlighting the interplay between neurobiological deficits and cognitive and emotional functioning as mediators of the link between early adversity and antisocial behavior problems in childhood. Implications for intervention programs are discussed.

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“…fMRI data focusing on children with conduct problems without accounting for individual differences in callous-unemotional traits have been mixed, with evidence of both amygdala hypo-and hyper-activity to affective stimuli (12,13,14). These mixed findings may partly reflect differences in paradigms used across studies.…”

Section: Introductionmentioning

confidence: 99%

Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits

Viding

Sebastian

Dadds

et al. 2012

AJP

336

306

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Abnormal neural responses to emotional visual stimuli in adolescents with conduct disorder

Cited by 282 publications

References 59 publications

Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation

Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation

The evidence for a neurobiological model of childhood antisocial behavior.

Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits

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