Abnormal neurochemical asymmetry in the temporal lobe of schizophrenia

Knockdown of phospholipase C-β1 in the medial prefrontal cortex of male mice impairs working memory among multiple schizophrenia endophenotypes

“…39,40 In addi tion, decreased PLCβ1 expression in the brains of patients with schizophrenia, particularly in the DLPFC, has suggested the possible pathogenic involvement of PLCβ1 in schizo phrenia. 13,14,21 Here, using mPFClimited, shRNAmediated silencing of PLCβ1, we generated a mouse model that mimics the decrease of PLCβ1 in the DLPFC of patients with schizophrenia. Behavioural characterization of these model mice revealed that mPFCspecific knockdown of PLCβ1 induced only the impaired working memory phenotype without producing the altered anxiety or other schizophrenia endophenotypes previously observed in PLCβ1 −/− mice.…”

“…4,[9][10][11][12] Moreover, decreased expression of PLCβ1 has been detected in the brains of patients with schizophrenia. [13][14][15][16][17][18] Schizophrenia symptoms are categorized into 3 major types 19,20 -positive, negative and cognitive -and a majority of these symptoms have been observed as endophenotypes in PLCβ1null (PLCβ1 −/− ) mice. [9][10][11][12] These symptoms include increased locomotion, impaired social behaviour, impaired prepulse inhibition (PPI), and impaired working memory.…”

Phosphoinositide-specific phospholipase C in health and disease

“…In fact, it is highly expressed in the cerebral cortex, hippocampus, amygdala, lateral septum, and olfactory bulb ( 67,68 ), where it regulates both cortical development and synaptic plasticity by specifi cally modulating hippocampal muscarinic acetylcholine receptor signaling. Moreover, a PI-PLC ␤ 1 gene deletion was observed in orbito-frontal cortex samples from human patients with schizophrenia and bipolar disorders (69)(70)(71), and patients with these diseases also showed an abnormal expression pattern of PI-PLC ␤ 1 in specifi c brain areas ( 66 ).…”

Deletion of PLCB1 gene in schizophrenia affected patients

“…A possible genetic association of PI-PLC ␤1 and schizophrenia was reported in linkage studies [63], and abnormal expression patterns in the brains of schizophrenia patients were reported [38,71].…”