Abnormal neuroendocrine responsivity to acute I.V. clomipramine challenge in depressed patients

Golden, Robert N.; Hsiao, John K.; Lane, Elizabeth A.; Ekstrom, David; Rogers, Sarah; Hicks, Richard E.; Potter, William Z.

doi:10.1016/0165-1781(90)90107-g

Cited by 49 publications

(19 citation statements)

References 28 publications

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“…The blunted PRL responses to CMI in depressed patients (unipolar and bipolar) are in agreement with previous reports using the same or other challenge tests [4][5][6][7][8] .…”

Section: Discussionsupporting

confidence: 81%

“…This approach has been extensively applied by several groups of investigators, who have measured the hormonal responses to serotonin probes tryptophan, fenfluramine, buspirone, meta -chlorophenylpiperidine, clomipramine (CMI) and citalopram [4][5][6][7][8] . These challenge test studies have been used as an index of serotonergic functional responsivity to test the hypothesis that this neurotransmitter system is dysregulated in depres-sion and mania: a blunted hormonal response is an index of the hypothesized reduced function of serotonergic system.…”

Section: Introductionmentioning

confidence: 99%

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Prolactin and Cortisol Responses to Acute Intravenous Clomipramine Challenge in Patients with Mania, Depression and Healthy Controls: Evidence for Reduced Serotonergic Responsivity

Lykouras

Markianos²,

Hatzimanolis

2010

Neuropsychobiology

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Serotonergic dysregulation has been shown to be involved in the pathophysiology of unipolar and bipolar depression. Neuroendocrine challenge tests have been extensively used to investigate serotonin functioning in the brain. Although the role of serotonin has received a great deal of attention using neuroendocrine challenge paradigms, little effort has been made to explore the role of serotonin in mania. We assessed serotonergic neuroendocrine responsivity in patients with depression (n = 22), mania (n = 11) and 15 healthy controls by measuring the prolactin (PRL) and cortisol responses to i.v. clomipramine (CMI) and searched for possible differences among the groups. Blunted PRL responses to CMI in manic and depressed patients compared to healthy controls were found. The response to CMI disclosed similar results for the 2 patient groups. No significant differences were found among the 3 subject groups in the cortisol response to CMI. The blunted PRL responses to CMI in patients with mania and depression suggest that serotonergic functioning in mania and depression is similarly impaired, at least at the level of hypothalamus-hypophysis.

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“…The blunted PRL responses to CMI in depressed patients (unipolar and bipolar) are in agreement with previous reports using the same or other challenge tests [4][5][6][7][8] .…”

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Prolactin and Cortisol Responses to Acute Intravenous Clomipramine Challenge in Patients with Mania, Depression and Healthy Controls: Evidence for Reduced Serotonergic Responsivity

Lykouras

Markianos²,

Hatzimanolis

2010

Neuropsychobiology

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“…Two studies have investigated both the PRL response to TRH and the PRL response to a 5-HT challenge in depression (Golden et al 1990;Anderson et al 1992). Both showed reduced PRL response to clomipramine but no difference in PRL response to TRH, in depressed subjects compared with healthy controls.…”

Section: Effects Of Corticosteroids On Gh and Prl Releasementioning

confidence: 99%

Corticosteroid-serotonin interactions in depression: a review of the human evidence

et al. 2004

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“…Several studies have described abnormal neuroendocrine responses to CMI challenge in depressed patients, in particular, blunted prolactin responses (Golden et al 1990a(Golden et al ,b, 1992 Anderson et al 1992). The blunted prolactin response to CMI challenge in depression does not appear to be attributable to lactotroph dysfunction, since depressed patients with blunted prolactin responses to CMI mount robust prolactin responses to other stimuli, i.e.…”

Section: Several Reports Have Described Abnormal Neuroendocrine Respomentioning

confidence: 99%

A Longitudinal Study of Serotonergic Function in Depression

Golden

Heine

Ekstrom

et al. 2002

Neuropsychopharmacology

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Several reports have described abnormal neuroendocrine responses to serotonergic challenge tests in depression, but few have studied depressed patients followed longitudinally. In order to determine whether blunted prolactin responses to clomipramine challenge is a "state" vs. "trait" marker in depression, we applied this challenge paradigm to 20 patients with Major Depression prior to treatment and at three additional time points following response to desipramine: at the completion of acute treatment (Maes and Meltzer 1995). Studies have reported abnormalities in various indirect indices of central serotonergic function in depressed patients, including post-mortem brain concentrations of serotonin (5-HT), its metabolites, and receptors; platelet 5-HT receptors; cerebrospinal fluid concentrations of 5-hydroxyindoleacetic acid; and neuroendocrine responses to 5-HT challenge tests (Maes and Meltzer 1995). The induction of clinical relapse in following acute tryptophan depletion in remitted depressed patients who had received treatment with serotonin selective reuptake inhibitors (SSRIs) (Delgado et al. 1990) suggests that 5-HT may also be involved in the mechanism of action of at least some successful antidepressant treatments, and that the correction of an underlying 5-HT dysfunction is linked to the initiation and maintenance of clinical remission.While there is a substantial body of data linking perturbations in these measures of 5-HT function to depression, it NO . 5 healthy control subjects who have no personal or family history of mood disorders. Differences between these groups of subjects could reflect either state or trait phenomena associated with depression. The most useful approach in distinguishing between these would involve longitudinal studies of depressed patients over the course of treatment and recovery from their illness. Several treatment studies have applied neuroendocrine challenge tests to depressed patients before and after antidepressant treatment, and to date, the results have been inconclusive. Some reports describe enhancement of the characteristically blunted prolactin response to 5-HT challenge in depressed patients following treatment, but this finding is not consistent (O'Keane et al. 1992;Shapira et al. 1989Shapira et al. , 1992Leatherman et al. 1993;Kasper et al. 1990). Others have compared 5-HT neuroendocrine challenge profiles in depressed patients who are receiving antidepressant pharmacotherapy, or who are in a current state of remission, to those of healthy volunteers or untreated patients (Flory et al. 1998;Meltzer et al. 1997). For a variety of practical and pragmatic reasons, it is difficult to reexamine in a longitudinal patient cohort 5-HT indices over the course of the acute and continuation phases of their illness, including a medication-free state of remission. However, this approach offers the greatest opportunity to dissect the trait vs. state nature of 5-HT dysregulation in depression.The clomipramine (CMI) challenge test meets the van Praag et al. (1987) cr...

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Abnormal neuroendocrine responsivity to acute I.V. clomipramine challenge in depressed patients

Cited by 49 publications

References 28 publications

Prolactin and Cortisol Responses to Acute Intravenous Clomipramine Challenge in Patients with Mania, Depression and Healthy Controls: Evidence for Reduced Serotonergic Responsivity

Prolactin and Cortisol Responses to Acute Intravenous Clomipramine Challenge in Patients with Mania, Depression and Healthy Controls: Evidence for Reduced Serotonergic Responsivity

Corticosteroid-serotonin interactions in depression: a review of the human evidence

A Longitudinal Study of Serotonergic Function in Depression

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