Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activation

Ellul, Pierre; Maruani, Anna; Peyre, Hugo; Vantalon, Valérie; Hoareau, Daphnée; Tiercelin, Hugo; Rosenzwajg, Michelle; Klatzmann, David; Delorme, Richard

doi:10.1038/s41598-023-49789-5

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…High levels of NLR are strongly linked to negative outcomes, so it is advisable to consider NLR as an unfavorable prognostic factor. Aside from assessing infectious diseases in children, the NLR is also utilized to predict the prognosis of autism 23 , surgical site infection 24 , asthma diagnosis and severity 25 , 26 , and attention-deficit/hyperactivity disorder 27 . This study shows that NLR is strongly associated with seizure susceptibility in FC.…”

Section: Discussionmentioning

confidence: 99%

A preliminary study on the association between prognostic nutritional index and neutrophil-to-lymphocyte ratio with nutritional status and inflammation in febrile children's susceptibility to seizures

Çetin,

Çetin

2024

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The aim of this study was to evaluate the association between nutritional status, inflammation, and susceptibility to seizures in febrile children. METHODS: This observational single-center study was carried out from January 2020 to December 2023 with 324 children aged 6 months and 6 years; 106 were diagnosed with febrile seizure, 108 were febrile children, and 110 were healthy controls. The prognostic nutritional index and neutrophil-to-lymphocyte ratio were calculated, and the cutoff threshold was established through receiver operating characteristics. The study utilized correlation and univariate–multivariate logistic regression analysis. The comparison between simple and complex febrile seizure was conducted to analyze differences. RESULTS: The optimal cutoff values were identified as 61.25 for prognostic nutritional index and 1.04 for neutrophil-to-lymphocyte ratio. Our findings showed a significant negative association between febrile seizure and platelet count, high C-reactive protein, and high ferritin levels. Additionally, the febrile seizure group showed a significant positive correlation with high neutrophil-to-lymphocyte ratio values (≥1.04) and body temperature (≥38). Our findings revealed that high neutrophil-to-lymphocyte ratio, high C-reactive protein, and age less than 18 months were independently associated with seizure susceptibility in febrile children. CONCLUSION: High neutrophil-to-lymphocyte ratio values and low prognostic nutritional index scores may serve as novel surrogate independent factors for seizure susceptibility in febrile children. Febrile children who are less than 18 months old are more prone to experience seizures than older febrile children. Moreover, there was a correlation between febrile seizures and elevated C-reactive protein levels and neutrophil-to-lymphocyte ratio values.

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Section: Discussionmentioning

confidence: 99%

A preliminary study on the association between prognostic nutritional index and neutrophil-to-lymphocyte ratio with nutritional status and inflammation in febrile children's susceptibility to seizures

Çetin,

Çetin

2024

Rev. Assoc. Med. Bras.

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“…As for other mental disorders (which have been studied in adolescents), elevated IHRs compared with healthy controls were demonstrated in adult patients with OCD [ 62 , 63 ] and SUD [ 64 , 65 ], and in children with ASD [ 66 , 67 , 68 ]. It should be noted that the number of such studies is limited and their results are somewhat contradictory, which makes comparisons extremely difficult, especially regarding the age-specificity.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Hematological Ratios in Adolescents with Mental Disorders: A Scoping Review

Popov,

Kosterin

et al. 2024

Consortium Psychiatricum

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BACKGOUND: Inflammatory hematological ratios (IHRs), such as neutrophil to lymphocyte, monocyte to lymphocyte, and platelet to lymphocyte ratios, are associated with mental disorders, symptoms severity, and the disease phase. Evidence from the studies in adult patients has been summarized in systematic reviews and meta-analyses. The results of the studies in adolescents remain poorly systematized. AIM: To summarize the findings from the studies that investigated the relationship of IHRs with mental disorders in adolescent patients. METHODS: This scoping review included studies of IHRs in patients aged 10–19 years with mental disorders (other than anorexia nervosa), published in English by December 31, 2023. The search for relevant papers was performed in MEDLINE. The studies were categorized into two groups: studies with external controls (healthy adolescents) and studies with internal controls (patients in different phases of mental disorder, with or without self-harm/suicidal behaviors). RESULTS: A total of 11 studies were included in the review (all cross-sectional ones). The results of these studies demonstrate that 1) adolescents with mental disorders (major depressive disorder, psychotic disorders, obsessive-compulsive disorder, attention deficit hyperactivity disorder, substance use disorders) have higher IHR values than individuals of the same age without corresponding disorders (5 studies); 2) IHR values are positively correlated with the severity of psychopathological symptoms (1 study); 3) higher IHR values are associated with the phase of the mental disorder — manic episode in bipolar disorder (1 study) and exacerbation of psychosis in psychotic disorders (1 study); and 4) higher IHR values are associated with self-harm/suicidal behaviors — suicide attempts (1 study) and non-suicidal self-injury (1 study). CONCLUSION: IHRs are associated with mental disorders in adolescents, and higher IHR values are associated with a more severe/acute clinical presentation (severity of symptoms, mania, acute psychosis, self-harm/suicidal behaviors). Further studies of higher methodological quality are needed to evaluate the diagnostic and prognostic value of IHRs as biomarkers of mental disorders in adolescence.

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The Role of Systemic Inflammation in Psychiatric Disorders Development in Children: Literature Review

Emelina,

Kravchenko,

Makarov

et al. 2024

Vopr. sovr. pediatr.

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There has been significant increase in mental disorders prevalence in pediatric population around the world. Increasing incidence of autism, intellectual incapacity, hyperkinetic disorders, and schizophrenia gives causes for specific concern. Clarifying mental disorders’ etiology and pathogenesis is the priority of researchers. The role of systemic inflammation in psychiatric disorders development currently remains the least studied. However, it can already be stated that generalized peripheral inflammation is the important factor associated with the development of mental disorders both in adults and children. This review presents latest data, as well as an authors’ assessment of systemic inflammation role in the most common mental disorders development in children. Comparative analysis of acute and chronic systemic inflammation manifestations has been performed. The major pathogenetic mechanisms of “systemic damage” in mental disorders have been identified.

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Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activation

Cited by 4 publications

References 38 publications

A preliminary study on the association between prognostic nutritional index and neutrophil-to-lymphocyte ratio with nutritional status and inflammation in febrile children's susceptibility to seizures

A preliminary study on the association between prognostic nutritional index and neutrophil-to-lymphocyte ratio with nutritional status and inflammation in febrile children's susceptibility to seizures

Inflammatory Hematological Ratios in Adolescents with Mental Disorders: A Scoping Review

The Role of Systemic Inflammation in Psychiatric Disorders Development in Children: Literature Review

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