Abnormal organization of inhibitory control functional networks in future binge drinkers

Antón‐Toro, Luis; Bruña, Ricardo; Suárez-Méndez, Isabel; Correas, Ángeles; García‐Moreno, Luis Miguel; Maestú, Fernando

doi:10.1016/j.drugalcdep.2020.108401

Cited by 17 publications

(25 citation statements)

References 52 publications

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“…This pattern also affected regions involved in inhibitory control networks, such as SMA, ACC and right IFG. 25 In conclusion, the present study revealed the presence of FC anomalies related to the motivational content of the stimuli during the successful inhibition of a prepotent response in binge drinkers. The results suggest that the presence of alcohol stimuli in the Go/NoGo task may hinder the ability of BDs to inhibit a prepotent response, so that compensatory cognitive control resources are required for successful task execution.…”

Section: Higher Fast-beta Fc In Bds During Response Inhibition To Noa...supporting

confidence: 52%

“…11 Additionally, we calculated the p100 visual component using the spatial filter beamformer, in order to check the robustness of source-space signal reconstruction (see the supporting information, Figure S1). 25…”

Section: Source Reconstructionmentioning

confidence: 99%

“…Orbital parts F I G U R E 1 Beverage Go/NoGo task: Subjects had to press the left-hand button of the mouse only in response to the Go stimuli (pictures of alcoholic or nonalcoholic beverages according to the condition)of right SFG and right MFG also showed higher FC with bilateral SMA. Figure2shows a topographical representation of the distribution of connectivity links.In addition, the BD group exhibited lower fast-beta(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) FC during correct response inhibition to Al stimuli than to NoAl stimuli. A pattern of hypoconnectivity between the right IFG and the right calcarine fissure was detected (p < 0.00006, FDR = 0.1).…”

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confidence: 98%

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Alcohol‐related stimuli modulate functional connectivity during response inhibition in young binge drinkers

et al. 2022

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Binge drinking is a pattern of intermittent excessive alcohol consumption that is highly prevalent in young people. Neurocognitive dual-process models have described substance abuse and adolescence risk behaviours as the result of an imbalance between an overactivated affective-automatic system (related to motivational processing) and damaged and/or immature reflective system (related to cognitive control abilities). Previous studies have evaluated the reflective system of binge drinkers (BDs) through neutral response inhibition tasks and have reported anomalies in theta (4-8 Hz) and beta (12-30 Hz) bands. The present study aimed to investigate the influence of the motivational value of alcohol-related stimuli on brain functional networks devoted to response inhibition in young BDs. Sixty eight BDs and 78 control participants performed a beverage Go/NoGo task while undergoing electrophysiological recording. Whole cortical brain functional connectivity (FC) was evaluated during successful response inhibition trials (NoGo). BDs exhibited fast-beta and theta hyperconnectivity in regions related to cognitive control. These responses were modulated differently depending on the motivational content of the stimuli. The increased salience of alcohol-related stimuli may lead to overactivation of the affective-automatic system in BDs, and compensatory neural resources of the reflective system will thus be required during response inhibition. In BDs, inhibition of the response to alcohol stimuli may require higher theta FC to facilitate integration of information related to the task goal (withholding a response), while during inhibition of the response to no-alcoholic stimuli, higher fast-beta FC would allow to apply topdown inhibitory control of the information related to the prepotent response.

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Section: Higher Fast-beta Fc In Bds During Response Inhibition To Noa...supporting

confidence: 52%

Section: Source Reconstructionmentioning

confidence: 99%

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confidence: 98%

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Alcohol‐related stimuli modulate functional connectivity during response inhibition in young binge drinkers

et al. 2022

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“…Second, we averaged the PLV values of all the links connecting each pair of 58 cortical regions of interest (ROI) according to the Harvard‐Oxford atlas, 33 obtaining a 58 × 58 whole‐brain FC matrix. Additionally, a number of quality‐check analyses were performed in order to enhance the robustness of the results and minimize or remove potential artefact‐driven outcomes 35 …”

Section: Methodsmentioning

confidence: 99%

"It's a beer!": Brain functional hyperconnectivity during processing of alcohol‐related images in young binge drinkers

et al. 2022

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Alcohol attentional bias has been pointed as a major marker of alcohol misuse.Recent evidence has revealed that brain functional connectivity (FC) may be a valuable index of the brain networks' integrity in young binge drinkers (BDs). However, there is no study to date examining the FC networks linked to the processing of alcohol-related images in this population. The present study aimed to explore the FC signatures underlying alcohol attention bias in young BDs. Thus, electroencephalographic (EEG) activity was recorded in 54 college students (55.5% females; 27 non/ low-drinkers and 27 BDs) while performing a visual alcohol cue-reactivity task. We evaluated whole-brain FC profiles during the processing of alcoholic and nonalcoholic cues, as well as their potential relationship with craving and severity of alcohol use. Results showed that, at the behavioural level, BDs rated alcohol-related images as more pleasant/attractive than non/low-drinkers. Furthermore, at the electrophysiological level, BDs exhibited increased beta-band FC-particularly in the fronto-parieto-occipital network-when processing alcoholic cues. Conversely, they displayed reduced theta-band FC relatively to non/low-drinkers for non-alcoholic images. These hyper-/hypo-connectivity patterns were associated with higher alcohol craving levels. Findings are congruent with previous neurofunctional studies reporting an attentional bias towards alcohol-related information in BDs. These results may have important clinical implications as this neural reactivity to alcoholic cues may contribute to the maintenance and/or escalation of the drinking pattern.Finally, the present study constitutes the first evidence showing that FC networks may be a sensitive indicator to alcohol attentional bias in BDs.

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“…Nonetheless, despite the important evidence provided by those studies, it remains unknown how BD predisposing profiles may be depicted by cortical electrophysiological dynamics. To our knowledge, only one MEG work explored this matter experimentally in relation to inhibitory control (IC) processes 26 . However, it is not entirely clear whether such abnormal connectivity is dependent of a particular set of cognitive processes (i.e.…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological resting‐state hyperconnectivity and poorer behavioural regulation as predisposing profiles of adolescent binge drinking

et al. 2022

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Adolescent Binge Drinking (BD) has become an increasing health and social concern, with detrimental consequences for brain development and functional integrity. However, research on neurophysiological and neuropsychological traits predisposing to BD are limited at this time. In this work, we conducted a 2-year longitudinal magnetoencephalography (MEG) study over a cohort of initially alcohol-naïve adolescents with the purpose of exploring anomalies in resting-state electrophysiological networks, impulsivity, sensation-seeking, and dysexecutive behaviour able to predict future BD patterns. In a sample of 67 alcohol-naïve adolescents (age = 14.5 ± 0.9), we measured resting-state activity using MEG. Additionally, we evaluated their neuropsychological traits using self-report ecological scales (BIS-11, SSS-V, BDEFS, BRIEF-SR and DEX). In a second evaluation, 2 years later, we measured participant's alcohol consumption, sub-dividing the original sample in two groups: future binge drinkers (22 individuals, age 14.6 ± 0.8; eight females) and future light/no drinkers (17 individuals, age 14.5 ± 0.8; eight females). Then, we searched for differences predating alcohol BD intake. We found abnormalities in MEG resting state, in a form of gamma band hyperconnectivity, in those adolescents who transitioned into BD years later. Furthermore, they showed higher impulsivity, dysexecutive behaviours and sensation seeking, positively correlated with functional connectivity (FC). Sensation seeking and impulsivity mainly predicted BD severity in the future, while the relationship between dysexecutive trait and FC with future BD was mediated by sensation seeking. These findings shed light to electrophysiological and neuropsychological traits of vulnerability towards alcohol consumption. We hypothesise that these differences may rely on divergent neurobiological development of inhibitory neurotransmission pathways and executive prefrontal circuits.

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Abnormal organization of inhibitory control functional networks in future binge drinkers

Cited by 17 publications

References 52 publications

Alcohol‐related stimuli modulate functional connectivity during response inhibition in young binge drinkers

Alcohol‐related stimuli modulate functional connectivity during response inhibition in young binge drinkers

"It's a beer!": Brain functional hyperconnectivity during processing of alcohol‐related images in young binge drinkers

Electrophysiological resting‐state hyperconnectivity and poorer behavioural regulation as predisposing profiles of adolescent binge drinking

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