Abnormal Pattern of Cortical Activation Associated With Voluntary Movement in Obsessive-Compulsive Disorder: An EEG Study

Leocani, Letizia; Locatelli, Marco; Bellodi, Laura; Fornara, C.; Henin, Marta; Magnani, Giuseppe; Mennea, S.; Comı, Gıancarlo

doi:10.1176/appi.ajp.158.1.140

Cited by 41 publications

(19 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, sup- pressed alpha activity has been recorded in schizophrenic patients over frontal and central regions (22,23), and around F7 sites in mania (24). Furthermore, results have included reports on less alpha on right than left anterior regions in depression (25), as well as the desynchronization of the alpha rhythm in obsessiveÁ/compulsive disorder (26). These observations point to the possible similarity of the neurobiological basis of PTSD or to similar biological consequences of different disorders.…”

Section: Discussionmentioning

confidence: 99%

Quantitative electroencephalogram (qEEG) in combat veterans with post-traumatic stress disorder (PTSD)

Jokić‐Begić

Begić

2003

Nordic Journal of Psychiatry

View full text Add to dashboard Cite

Only a small number of studies have used quantitative electroencephalography (qEEG) in research of the post-traumatic stress disorder (PTSD). The results are not consistent. The aim of the present investigation was to compare qEEG in combat veterans with and without PTSD. The hypothesis is that differences among qEEG characteristics will be found regarding the presence/absence of PTSD. Seventy-nine combat veterans with PTSD comprised the experimental group and 37 veterans without PTSD were included as controls. After the informed consent, they were investigated by the resting EEG recordings. The results demonstrate that PTSD veterans had decreased alpha power and increased beta power. These results suggest an altered neurobiology in PTSD. Various explanations have been offered for alpha activity decrease observed in PTSD veterans. Increased beta rhythm may play a role as a potential marker in differentiating subtypes of PTSD.

show abstract

Section: Discussionmentioning

confidence: 99%

Quantitative electroencephalogram (qEEG) in combat veterans with post-traumatic stress disorder (PTSD)

Jokić‐Begić

Begić

2003

Nordic Journal of Psychiatry

View full text Add to dashboard Cite

show abstract

“…supported by neurophysiological (Bannon et al, 2002;Di Russo et al, 2000;Leocani et al, 2001), neuroradiological (Jenike et al, 1996;Kim et al, 2001;Scarone et al, 1992;Stein et al, 1993), and metabolic (Baxter et al, 1987;Benkelfat et al, 1990;Perani et al, 1995) studies that have reported a relationship between OCD and brain circuits that are posited to connect the frontal cortex to basal ganglia structures in the physiological model proposed by Alexander (1986).…”

Section: An Overview Of Neurobiological Models Of Obsessive-compulsivmentioning

confidence: 96%

Understanding Obsessive–Compulsive Disorder: Focus on Decision Making

2006

Self Cite

View full text Add to dashboard Cite

Current approaches to obsessive-compulsive disorder (OCD) have suggested that neurobiological abnormalities play a crucial role in the etiology and course of this psychiatric illness. In particular, a fronto-subcortical circuit, including the orbitofrontal cortex, basal ganglia and thalamus appears to be involved in the expression of OCD symptoms. Neuropsychological studies have also shown that patients with OCD show deficits in cognitive abilities that are strictly linked to the functioning of the frontal lobe and its related fronto-subcortical structures, such as executive functioning deficits and insufficient cognitive-behavioral flexibility. This article focuses on decision making, an executive ability that plays a crucial role in many real-life situations, whereby individuals choose between pursuing strategies of action that involve only immediate reward and others based on long-term reward. Although the role of decision-making deficits in the evolution of OCD requires further research, the collected findings have significant implications for understanding the clinical and behavioral heterogeneity that characterizes individuals with OCD.

show abstract

“…It has been hypothesized that malfunctioning of corticostriato-thalamocortical circuitry, and in particular deficits in inhibition of irrelevant information and response control [3,5], may account for the reduced ability of patients with OCD to inhibit intrusive thoughts, impulses, or images, as well as repetitive motor responses and/or mental rituals. This deficient inhibition is thought to have a neurophysiological signature that is an increased level of cortical excitability [25,33]. In a number of studies of our group, transcranial magnetic stimulation (TMS) of motor cortex has been used to evaluate both cortical facilitatory and inhibitory mechanisms in different groups of patients [16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study

Khedr

Elbeh

Elserogy

et al. 2016

Neurophysiologie Clinique/Clinical Neurophysiology

View full text Add to dashboard Cite

Abnormal Pattern of Cortical Activation Associated With Voluntary Movement in Obsessive-Compulsive Disorder: An EEG Study

Abstract: Delayed event-related desynchronization in OCD is consistent with involvement of structures related to motor programming, such as basal ganglia. Lower levels of postmovement beta synchronization suggest impairment of the inhibitory system in OCD.

Cited by 41 publications

References 8 publications

Quantitative electroencephalogram (qEEG) in combat veterans with post-traumatic stress disorder (PTSD)

Quantitative electroencephalogram (qEEG) in combat veterans with post-traumatic stress disorder (PTSD)

Understanding Obsessive–Compulsive Disorder: Focus on Decision Making

Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study

Contact Info

Product

Resources

About