Abnormal Patterns of Mucin Secretion in Ileal Neobladder Mucosa: Evidence of Preneoplastic Lesion?

Parenti, Anna; Aragona, Francesco; Bortuzzo, Germana; DeCaro, Raffaele; Pagano, Francesco

doi:10.1159/000019826

Cited by 21 publications

(8 citation statements)

References 22 publications

(18 reference statements)

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“…In a follow-up prospective study of 24 patients with orthotopic ileal neobladder who underwent regular endoscopic biopsy for 5 years after surgery, progressive changes to the ileal mucosa were seen, with thinning, increased goblet cells, and villous atrophy, but no dysplasia and no malignancy [ 26 ]. Three similar studies of patients with orthotopic ileal neobladder (4-year follow-up study of 30 patients [ 27 ], 7-year follow-up study of 90 patients [ 28 , 29 ], and 10-year follow-up study of 20 patients [ 30 ]) found similar progressive changes to the ileal mucosa, but with no atrophy, no dysplasia and no malignancy. Additionally, histochemical staining revealed the increased presence of mucin (sulfomucins and sialomucins) immediately postoperatively which gradually reduced with extended follow-up [ 26 - 30 ].…”

Section: Discussionmentioning

confidence: 91%

Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case

2007

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Neoplasms of the urinary bladder following augmentation ileocystoplasty are rare. We present the case of a 39-year-old male with a tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty to enlarge a post-chemoradiation-induced shrunken bladder. He presented with gross hematuria. Cystoscopy revealed a papillary tumor at the site of ileovesical anastomosis, and transurethral resection was performed. Histologic examination revealed a tubular adenoma with high-grade dysplasia. There are only two previous reports of tubulovillous adenoma in ileal segment after ileocystoplasty, both without high-grade dysplasia. Our observation supports the hypothesis that an ileal neobladder may undergo all the morphologic and molecular changes observed in the development of gastrointestinal adenocarcinoma. Therefore, patients who had an ileal neobladder created should be closely followed.

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Section: Discussionmentioning

confidence: 91%

Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case

2007

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“…[11][12][13][14][15] Carcinogenic effects of normal urine and urinary stasis (as in continent diversion) have also been associated with a risk of cancer in bowel segments used for urinary diversion, most commonly adenocarcinoma. Another theory of carcinogenesis has been suggested involving bacterial activation of endogenously formed N-nitrosamine.…”

Section: Discussionmentioning

confidence: 99%

First case of invasive squamous cell carcinoma in a stoma of a Monti ileovesicostomy

Reid¹,

Althunayan

Capolicchio³

et al. 2014

CUAJ

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We report a very rare case of invasive squamous cell carcinoma (SCC) in the abdominal stoma of a Monti ileovesicostomy. Our patient underwent an uncomplicated Monti ileovesicostomy at age 16 for a neurogenic bladder. She presented 10 years later with difficulty catheterizing the stoma. A biopsy of peristomal tissue showed moderately differentiated SCC. A cystoscopy did not reveal any bladder tumours or suspicious lesions. A computed tomography (CT) scan of the abdomen and pelvis did not demonstrate metastasis. The patient underwent a complete en bloc resection of the stomal site, the Monti, a partial cuff of bladder, and 2 loops of bowel that were adherent to the Monti. Final pathology revealed pure invasive SCC arising around the stoma and negative surgical margins. Six months later, a follow-up CT scan showed no evidence of malignancy, while a cystoscopy revealed a small erythematous area in the posterior bladder wall. Urinary cytology was positive for SCC. Transurethral resection of the erythematous lesion with random bladder biopsies showed SCC in situ in the erythematous lesion and right lateral bladder wall. Staging workup was negative. The patient subsequently underwent a radical cystectomy and ileal conduit diversion with bilateral pelvic lymph node dissection. Final pathology on cystectomy specimen was SCC in situ without evidence of invasive carcinoma. The patient has remained in remission at the 3-year follow-up.

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“…Very recently, Di Tonno et al . reported that colonic metaplasia, already described as premalignant in the stomach, occurred in the long‐term follow‐up of the ileal neobladder, although it is unclear whether these phenotypic changes may be defined as preneoplastic or only metaplastic 5,6 …”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma arising at the ileoileal anastomotic site of Scheele's ring

et al. 2003

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Most tumors arising after augmentation ileocystoplasty have been reported to develop adjacent to the ileovesical anastomosis. Herein, we report a case of adenocarcinoma arising at the ileoileal anastomotic site 33 years after augmentation ileocystoplasty (Scheele's ring plasty) for tuberculous contracted bladder. The present case shows the possibility of late malignancy developing at the ileoileal junction after ileal neobladder.

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Abnormal Patterns of Mucin Secretion in Ileal Neobladder Mucosa: Evidence of Preneoplastic Lesion?

Cited by 21 publications

References 22 publications

Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case

Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case

First case of invasive squamous cell carcinoma in a stoma of a Monti ileovesicostomy

Adenocarcinoma arising at the ileoileal anastomotic site of Scheele's ring

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