Abnormal Photic Driving Responses in Never-medicated Schizophrenia Patients

Wada, Yuji; Takizawa, Yuko; Yamaguchi, Nariyoshi

doi:10.1093/schbul/21.1.111

Cited by 28 publications

(12 citation statements)

References 16 publications

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“…It is a rhythmic activity elicited over the posterior regions, consisting of rhythmic EEG activity. The difference in photic driving to light stimulation between healthy and epileptic patients, schizophrenia, and dementia has been reported [10-13]. Photic driving by photic stimulation of high frequency (≥15 Hz) is called the H-response, and is observed in the interictal phase in migraine patients [4].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Electroencephalogram Using Exact Low-Resolution Electromagnetic Tomography During Photic Driving Response in Patients with Migraine

et al. 2018

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Background: Photophobia is a common feature of migraine, which may involve abnormal cortical information processing. In electroencephalograms (EEG), photic driving is known as a reaction to visual stimulation. Both photophobia and photic driving response are present during light stimulation. We hypothesized that cortical response to photic stimulation would differ between migraine patients with and without aura. Methods: We recruited 50 migraine patients (migraine with aura [MWA] = 21; migraine without aura [MWOA] = 29). Spontaneous eyes-closed resting EEG from 20 electrodes on the scalp during the interictal phase was recorded. After recording, each photic stimulation was separately selected. We analyzed EEG by fast Fourier transform and observed the spectrum frequency peaks and topographies in response to photic stimulation. Exact low-resolution electromagnetic tomography (eLORETA) was used to compute the 3-dimensional intracerebral distribution of EEG activity. Results: Photic stimulation at frequencies 5, 8, 15, and 20 Hz showed significant differences between migraine patients with and without aura. MWOA patients consistently had a stronger response to photic stimulation than MWA patients. In all patients, the differential response was located in the visual cortex, except for the stimulation at 20 Hz, where the difference at subharmonic 10 Hz was located in the parietal cortex (Brodmann Area 7). Conclusion: We confirmed high incidences of photic hypersensitivity and photic driving responses in migraine patients. We suggest that repeated occurrences of cortical spreading depression in MWA may suppress cortical function, thus contributing to a weaker visual cortical response to photic stimulation in MWA patients compared with MWOA patients.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Electroencephalogram Using Exact Low-Resolution Electromagnetic Tomography During Photic Driving Response in Patients with Migraine

et al. 2018

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“…The photic driving response was first reported in 1934 [8], and differences between healthy and epileptic patients were reported in 1981 [9]. Differences between healthy patients and those with schizophrenia and dementia were subsequently reported [10,11,12]. …”

Section: Discussionmentioning

confidence: 99%

Topographic Analysis of Electroencephalographic Changes during Photic Driving Responses in Patients with Migraine

et al. 2015

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Objective: Migraineurs demonstrate abnormal information processing such as photic hypersensitivity. The photic driving response to photic stimulation (PS) is a reaction to the visual stimulation of electroencephalography (EEG). Both the photic driving response and photic hypersensitivity appear during light stimulation. We considered that evaluation of a migraineur's photic driving response may help to elucidate the mechanism of the migraineur's sensitive condition. Our study aimed to investigate EEG photic driving responses with a source-localizing method. Methods: We recorded spontaneous resting EEG with eyes closed from 20 electrodes on the scalp during the interictal phase. After recording, each PS was separately selected. We also analyzed EEG by fast Fourier transform and observed the spectrum frequency peaks and topographies in response to PS. Results: The photic driving response could be observed at a flashing rate of >15 Hz. Patients with photic hypersensitivity tended to show more photic driving regardless of the migraine subtype. Moreover, in topographies, their activated areas were shifted anteriorly from fundamental driving to harmonic driving for each photic frequency. This anterior shift was more evident with a longer duration of illness, although no significant differences were seen between migraine subtypes. The global field power value had a positive correlation with the duration of illness. Conclusion: Photic hypersensitivity and photic driving responses were increased in migraineurs. Photic hypersensitivity might result in sensitization of the limbic system.

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“…Therefore, the normative data about the peculiarities of the profile shape in various cortical areas of healthy children and adolescents are important as controls for clinical studies. The topographic parameters of the normal driving reaction, such as the interhemispheric symmetry of the profiles with some prevalence of the right hemisphere in the occipital areas, their gradual amplitude decrease in the frontal direction with a decrease of intrahemispheric correlation and an increase of the weight of the theta peak, etc., can be compared with those of the patients with regional alterations in cerebral functioning of both an organic and functional nature (14)(15)(16)(17)(18)(21)(22)(23). Our preliminary results obtained for some children suffering from migraine actually demonstrated a pronounced interhemispheric asymmetry in the profile shape not observed in the resting EEG spectra.…”

Section: Discussionmentioning

confidence: 99%

“…Their lower photic driving occurred across most brain areas except for the centrotemporal regions (21), and in the frontal areas, it could be higher than in the occipital ones (22). Some reduction in photic driving and significant topographic alterations were found in the parieto-occipital regions of patients with presenile Alzheimer's disease (23).…”

Section: Introductionmentioning

confidence: 99%

Topographic aspects of photic driving in the electroencephalogram of children and adolescents

Лазарев

Infantosi

Valencio-de-Campos

et al. 2004

Braz J Med Biol Res

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The electroencephalogram amplitude spectra at 11 fixed frequencies of intermittent photic stimulation of 3 to 24 Hz were combined into driving "profiles" for 14 scalp points in 8 male and 7 female normal subjects aged 9 to 17 years. The driving response varied over frequency and was detected in 70 to 100% of cases in the occipital areas (maximum) and in 27 to 77% of cases in the frontal areas (minimum) using as a criterion peak amplitude 20% higher than those of the neighbors. Each subject responded, on average, to 9.7 ± 1.15 intermittent photic stimulation frequencies in the right occipital area and to 6.8 ± 1.97 frequencies in the right frontal area. Most of the driving responses (in relation to the previous background) were significant according to the spectral F-test (α = 0.05), which also detected changes in some cases of low amplitude responses not revealed by the peak criterion. The profiles had two maxima in the alpha and theta bands in all leads. The latter was not present in the background spectra in the posterior areas and was less pronounced in the anterior ones. The weight of the profile theta maximum increased towards the frontal areas where the two maxima were similar, while the profile amplitudes decreased. The profiles repeated the shape of the background spectra, except for the theta band. The interhemispheric correlation between profiles was high. The theta driving detected in all areas recorded suggests a generalized influence of the theta generators in prepubertal and pubertal subjects.

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Abnormal Photic Driving Responses in Never-medicated Schizophrenia Patients

Cited by 28 publications

References 16 publications

Evaluation of Electroencephalogram Using Exact Low-Resolution Electromagnetic Tomography During Photic Driving Response in Patients with Migraine

Evaluation of Electroencephalogram Using Exact Low-Resolution Electromagnetic Tomography During Photic Driving Response in Patients with Migraine

Topographic Analysis of Electroencephalographic Changes during Photic Driving Responses in Patients with Migraine

Topographic aspects of photic driving in the electroencephalogram of children and adolescents

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