Abnormal Placentation

Rao, Kiran; Belogolovkin, Victoria; Yankowitz, Jerome; Spinnato, Joseph A.

doi:10.1097/ogx.0b013e3182685870

Cited by 72 publications

(21 citation statements)

References 171 publications

(154 reference statements)

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“…The observed positive association between TTP and placental disorders was evident after control for maternal age and fertility treatment use, which are well-established independent risk factors for placental disorders (32). These findings were relatively uniform across maternal age and parity status.…”

Section: Discussionmentioning

confidence: 85%

Prospective study of time to pregnancy and adverse birth outcomes

Wise

Mikkelsen

Sørensen

et al. 2015

Fertility and Sterility

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Objective To investigate the association between time-to-pregnancy (TTP) and adverse birth outcomes. Design Prospective cohort study. Setting Internet-based observational study of Danish pregnancy planners (2007-2012). Patient(s) 3,521 singletons born to women aged 18-40 years at cohort entry. Intervention(s) None. Main outcome measure(s) selected birth outcomes—including preterm birth (PTB, <37 weeks’ gestation), low birth weight (LBW, <2500 g), small-for-gestational age (SGA), large-for-gestational age (LGA), and placental disorders— ascertained from the Danish Medical Birth Registry and Danish National Registry of Patients. Risk ratios (RR) and 95% confidence intervals (CI) were estimated using log-binomial regression, with adjustment for potential confounders and fertility treatment. Results Multivariable RRs for PTB in relation to TTP of 3-5, 6-11, and ≥12 versus <3 cycles were: 1.59 (CI: 0.94, 2.69), 0.85 (CI: 0.48, 1.50), and 1.57 (CI: 0.93, 2.65). The association was slightly stronger for spontaneous PTB (TTP ≥12 versus <3 cycles: RR=1.69, CI: 0.84, 3.42) than medically-indicated PTB (RR=1.39, 95%: 0.62, 3.12). Longer TTPs (≥12 cycles) were associated with increased risks of LBW (RR=1.80, CI: 0.97, 3.35), caesarean delivery (RR=1.64, CI: 1.27, 2.12), placental disorders (RR=2.21, CI: 1.07, 4.56), ischemic placental disease (RR=1.56, CI: 0.99, 2.44), preeclampsia (RR=1.45, CI: 0.79, 2.65), and postpartum hemorrhage (RR=1.58, CI: 1.14, 2.19), and decreased risks of macrosomia (≥4,500g; RR=0.63, CI: 0.35, 1.13) and LGA (RR=0.76, CI: 0.58, 1.00). Longer TTP showed little association with SGA. Conclusion In a prospective cohort study of Danish pregnancy planners, delayed conception was a marker for adverse birth outcomes, after accounting for fertility treatment.

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Section: Discussionmentioning

confidence: 85%

Prospective study of time to pregnancy and adverse birth outcomes

Wise

Mikkelsen

Sørensen

et al. 2015

Fertility and Sterility

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“…Women with a diagnosis of placenta previa that delivered vaginally (n=26) were not considered as cases for the purposes of this study as partial and complete placenta previa require cesarean delivery. 3,6 …”

Section: Methodsmentioning

confidence: 99%

Previous prelabor or intrapartum cesarean delivery and risk of placenta previa

Downes

Hinkle

Sjaarda

et al. 2015

American Journal of Obstetrics and Gynecology

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Objective To examine the association between previous cesarean delivery and subsequent placenta previa while distinguishing cesarean delivery prior to onset of labor from intrapartum cesarean delivery. Study Design Retrospective cohort study of electronic medical records from 20 Utah hospitals (2002–2010) with restriction to the first two singleton deliveries of women nulliparous at study entry (n=26,987). First pregnancy delivery mode was classified as 1) vaginal (reference); 2) cesarean delivery prior to labor onset (prelabor); or 3) cesarean delivery after labor onset (intrapartum). Risk of second delivery previa was estimated by prior delivery mode using logistic regression and adjusted for maternal age, insurance, smoking, co-morbidities, prior pregnancy loss, and history of previa. Results The majority of first deliveries were vaginal (82%, n=22,142), followed by intrapartum cesarean delivery (14.6%, n=3,931), or prelabor cesarean delivery (3.4%, n=914). Incidence of second delivery previa was 0.29% (n=78) and differed by prior delivery mode: vaginal, 0.24%; prelabor cesarean delivery, 0.98%; intrapartum cesarean delivery, 0.38% (P<0.001). Relative to vaginal delivery, prior prelabor cesarean delivery was associated with an increased risk of second delivery previa (adjusted odds ratio, 2.62 [95% confidence interval, 1.24–5.56]). There was no significant association between prior intrapartum cesarean delivery and previa [adjusted odds ratio, 1.22 (95% confidence interval, 0.68–2.19)]. Conclusion Prior prelabor cesarean delivery was associated with a more than two-fold significantly increased risk of previa in the second delivery, while the approximately 20% increased risk of previa associated with prior intrapartum cesarean delivery was not significant. Although rare, the increased risk of placenta previa after prior prelabor cesarean delivery may be important when considering non-medically indicated prelabor cesarean delivery.

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“…Moreover, IVF pregnancies are often complicated by a high risk of the vanishing twin syndrome (Pinborg et al, 2006), one cause of which might be embryo crowding at implantation and subsequent resorption of one fetus by the twin (Chen et al, 2011; Daikoku et al, 2011; Liu and Armant, 2004; Nallasamy et al, 2012; Sun et al, 2012; Xie et al, 2007; Ye et al, 2011). Placenta previa is a human pregnancy complication in which the placenta is situated close to or completely covering the cervix (Allahdin et al, 2011; Bulletti and de Ziegler, 2006; Rao et al, 2012), affecting approximate 0.5% of human pregnancies. And one risk factor for this complication could also be aberrant embryo spacing (Wang and Dey, 2006).…”

Section: Emerging Concept: the Quality Of Implantation Determines mentioning

confidence: 99%

Physiological and molecular determinants of embryo implantation

Zhang

Lin

Kong

et al. 2013

Molecular Aspects of Medicine

450

480

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Embryo implantation involves the intimate interaction between an implantation-competent blastocyst and a receptive uterus, which occurs in a limited time period known as the window of implantation. Emerging evidence shows that defects originating during embryo implantation induce ripple effects with adverse consequences on later gestation events, highlighting the significance of this event for pregnancy success. Although a multitude of cellular events and molecular pathways involved in embryo-uterine crosstalk during implantation have been identified through gene expression studies and genetically engineered mouse models, a comprehensive understanding of the nature of embryo implantation is still missing. This review focuses on recent progress with particular attention to physiological and molecular determinants of blastocyst activation, uterine receptivity, blastocyst attachment and uterine decidualization. A better understanding of underlying mechanisms governing embryo implantation should generate new strategies to rectify implantation failure and improve pregnancy rates in women.

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Abnormal Placentation

Cited by 72 publications

References 171 publications

Prospective study of time to pregnancy and adverse birth outcomes

Prospective study of time to pregnancy and adverse birth outcomes

Previous prelabor or intrapartum cesarean delivery and risk of placenta previa

Physiological and molecular determinants of embryo implantation

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