Abnormal Radial Deformation Hyperacuity in Children with Strabismic Amblyopia

Subramanian, Vidhya; Morale, Sarah E.; Wang, Yizhong; Birch, Eileen E.

doi:10.1167/iovs.11-8774

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…However, we did not observe a relationship between visual acuity and motor coordination, gross motor or fine motor scores. The relationship between visual acuity and the Beery visual perception score is expected as the visual perception test is designed to detect spatial vision impairments that might complicate the interpretation of visual motor integration scores (Subramanian, Morale, Wang, & Birch, 2012). It is important to note that <5% of the children in our study had abnormal visual acuity for their age and therefore our results do not bear upon the relationship between impaired visual acuity and motor function.…”

Section: Discussionmentioning

confidence: 99%

Global motion perception is related to motor function in 4.5-year-old children born at risk of abnormal development

et al. 2017

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Global motion perception is often used as an index of dorsal visual stream function in neurodevelopmental studies. However, the relationship between global motion perception and visuomotor control, a primary function of the dorsal stream, is unclear. We measured global motion perception (motion coherence threshold; MCT) and performance on standardized measures of motor function in 606 4.5-year-old children born at risk of abnormal neurodevelopment. Visual acuity, stereoacuity and verbal IQ were also assessed. After adjustment for verbal IQ or both visual acuity and stereoacuity, MCT was modestly, but significantly, associated with all components of motor function with the exception of gross motor scores. In a separate analysis, stereoacuity, but not visual acuity, was significantly associated with both gross and fine motor scores. These results indicate that the development of motion perception and stereoacuity are associated with motor function in pre-school children.

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Section: Discussionmentioning

confidence: 99%

Global motion perception is related to motor function in 4.5-year-old children born at risk of abnormal development

et al. 2017

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“…A few protocols described in this review are beginning to be standardized for possible clinical use. Examples are contour integration ( Kovács et al, 2000 ; Chandna et al, 2001 ), radial frequency deformations ( Subramanian et al, 2012 ), interocular suppression ( Black et al, 2011 ), and the Jane task ( Mondloch et al, 2002 ). Further progress in this area will help to improve our understanding of extra-striate function in amblyopia.…”

Section: Discussionmentioning

confidence: 99%

“…However, signal/noise segregation is not sufficient to account for all global form deficits reported for observers with amblyopia. For example, deficits in the perception of radial frequency patterns have been reported in the amblyopic eyes of small groups of adults ( Hess et al, 1999 ; Dallala et al, 2010 ), and a large group of children ( Subramanian et al, 2012 ) with strabismic amblyopia. A similar result was found for participants with deprivation amblyopia ( Jeffrey et al, 2004 ).…”

Section: Global Deficits In Amblyopiamentioning

confidence: 99%

Global processing in amblyopia: a review

et al. 2014

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Amblyopia is a neurodevelopmental disorder of the visual system that is associated with disrupted binocular vision during early childhood. There is evidence that the effects of amblyopia extend beyond the primary visual cortex to regions of the dorsal and ventral extra-striate visual cortex involved in visual integration. Here, we review the current literature on global processing deficits in observers with either strabismic, anisometropic, or deprivation amblyopia. A range of global processing tasks have been used to investigate the extent of the cortical deficit in amblyopia including: global motion perception, global form perception, face perception, and biological motion. These tasks appear to be differentially affected by amblyopia. In general, observers with unilateral amblyopia appear to show deficits for local spatial processing and global tasks that require the segregation of signal from noise. In bilateral cases, the global processing deficits are exaggerated, and appear to extend to specialized perceptual systems such as those involved in face processing.

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“…Since then, vision scientists have investigated if threshold changes as part of the normal ageing processes 14,15 or is affected in patients with macular degeneration 16 or amblyopia. [17][18][19] In this study, we aim to establish normative shape discrimination thresholds among subjects with emmetropia and corrected myopia and document any difference in thresholds, particularly given the lack of concordance in standard acuity and contrast sensitivity measures reported by earlier investigators. 6,[8][9][10][11] As four out of five of our young South East Asian adults have myopic refractive error, the documentation of normative thresholds among subjects with corrected myopia and its comparison with subjects with emmetropia will have significant clinical benefits, especially since some researchers 20 have been actively testing clinical tools for shape-discrimination to monitor visual function in patients with maculopathy.…”

mentioning

confidence: 99%

“…In performing this task, normal observers have modulation detection thresholds as low as two to four seconds of arc—well within the hyperacuity range. Since then, vision scientists have investigated if threshold changes as part of the normal ageing processes or is affected in patients with macular degeneration or amblyopia …”

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confidence: 99%

Shape discrimination thresholds among subjects with emmetropia and corrected myopia

Rajeev

Tan

Liyana

et al. 2015

Clinical and Experimental Optometry

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Background: Myopia is highly prevalent in some Asian countries yet the ability of subjects with myopia to discriminate shapes using radial frequency (RF) patterns-circular patterns that are defined by sinusoidal modulation of the radius in polar coordinates-is not well documented. In this psychophysical study, we explore the relative ability of subjects with corrected myopia to discriminate shapes using radial frequency patterns. Specifically, the aims were to find if there are any differences in modulation detection thresholds among subjects with emmetropia and corrected myopia and to establish thresholds as a function of myopic refractive error. Methods: Shape discrimination thresholds were measured for subjects with emmetropia (n = 20) and corrected myopia (n = 20) using circular D4 (fourth derivative of Gaussian) radial frequency patterns. A total of five radial frequency patterns (RF1 to RF16) with peak spatial frequencies of 2, 4, 6 and 8 (SF2 to SF8) cycles per degree were studied. The radial frequency suffix determines the number of deformation cycles present around the circumference, while the peak spatial frequency is related to the thickness of the circular contour. Results: Overall, shape discrimination thresholds were not significantly different (p > 0.05) between subjects with emmetropia and corrected myopia. Similarly, there was no significant correlation (p > 0.05) in thresholds with the magnitude of corrected myopia. Shape discrimination performance was best for RF8 patterns, with thresholds ranging from nine to 12 seconds of arc for SF2 to SF6 patterns and from 20 to 22 seconds of arc for SF8 patterns. Thresholds were significantly higher (p < 0.05) for SF8 patterns compared to the other spatial frequency patterns (SF2 to SF6) for all radial frequency patterns. The average thresholds increased by about 1 to 1.5 log units from RF1 to RF4 and RF8. Conclusion: Across all patterns studied here, shape discrimination thresholds remain at hyperacuity levels and are not degraded in subjects with corrected myopia compared to emmetropia.

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Abnormal Radial Deformation Hyperacuity in Children with Strabismic Amblyopia

Cited by 10 publications

References 26 publications

Global motion perception is related to motor function in 4.5-year-old children born at risk of abnormal development

Global motion perception is related to motor function in 4.5-year-old children born at risk of abnormal development

Global processing in amblyopia: a review

Shape discrimination thresholds among subjects with emmetropia and corrected myopia

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