Abnormal regional homogeneity in young adult suicide attempters with no diagnosable psychiatric disorder: A resting state functional magnetic imaging study

Cao, Jian; Chen, Jianmei; Kuang, Li; Ai, Ming; Fang, Weidong; Gan, Yong; Wang, Wo; Chen, Xiaorong; Xu, Xiaoming; Wang, Heng-guang; Lv, Zhen

doi:10.1016/j.pscychresns.2014.10.011

Cited by 57 publications

(50 citation statements)

References 62 publications

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“…Higher regional homogeneity in these areas or adjacent areas is associated with longer durations of migraine 61 , and suicide attempts 62 . Furthermore, remission from major depressive disorder with panic disorder is associated with decreased regional homogeneity in these areas 63 .…”

Section: Discussionmentioning

confidence: 99%

Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting from working memory training

Takeuchi

Taki

Nouchi

et al. 2017

Sci Rep

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Working memory training (WMT) induces changes in cognitive function and various neurological systems. Here, we investigated changes in recently developed resting state functional magnetic resonance imaging measures of global information processing [degree of the cortical hub, which may have a central role in information integration in the brain, degree centrality (DC)], the magnitude of intrinsic brain activity [fractional amplitude of low frequency fluctuation (fALFF)], and local connectivity (regional homogeneity) in young adults, who either underwent WMT or received no intervention for 4 weeks. Compared with no intervention, WMT increased DC in the anatomical cluster, including anterior cingulate cortex (ACC), to the medial prefrontal cortex (mPFC). Furthermore, WMT increased fALFF in the anatomical cluster including the right dorsolateral prefrontal cortex (DLPFC), frontopolar area and mPFC. WMT increased regional homogeneity in the anatomical cluster that spread from the precuneus to posterior cingulate cortex and posterior parietal cortex. These results suggest WMT-induced plasticity in spontaneous brain activity and global and local information processing in areas of the major networks of the brain during rest.

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Section: Discussionmentioning

confidence: 99%

Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting from working memory training

Takeuchi

Taki

Nouchi

et al. 2017

Sci Rep

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“…In particular, the PHG may play a critical role in providing an interface for the interaction of emotion, cognitive evaluation and episodic autobiographical memory for helping identify the social and emotional context of an episode (Aggleton, 2012). Therefore, dysfunctional parahippocampal circuits may disrupt limbic pathways involved in affect regulation (Cao et al, 2015). The amygdala has been consistently considered to play a central role in both emotional perception and arousal (LeDoux, 2000).…”

Section: Discussionmentioning

confidence: 99%

Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study

Gao

Liu

et al. 2016

Front. Hum. Neurosci.

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Abnormal functional connectivity (FC) at rest has been identified in clinical depressive disorder. However, very few studies have been conducted to understand the underlying neural substrates of subclinical depression. The newly proposed centrality analysis approach has been increasingly used to explore the large-scale brain network of mental diseases. This study aimed to identify the degree centrality (DC) alteration of the brain network in subclinical depressive subjects. Thirty-seven candidates with subclinical depression and 34 well-matched healthy controls (HCs) were recruited from the same sample of college students. All subjects underwent a resting-state fMRI (rs-fMRI) scan to assess the DC of the whole brain. Compared with controls, subclinical depressive subjects displayed decreased DC in the right parahippocampal gyrus (PHG), left PHG/amygdala, and left caudate and elevated DC in the right posterior parietal lobule (PPL), left inferior frontal gyrus (IFG) and left middle frontal gyrus (MFG). In addition, by using receiver operating characteristic (ROC) analysis, we determined that the DC values in the regions with altered FC between the two groups can be used to differentiate subclinical depressive subjects from HCs. We suggest that decreased DC in subcortical and increased DC in cortical regions might be the neural substrates of subclinical depression.

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“…The persistence of these relationships after controlling for methamphetamine use suggests that weak connectivity between these regions may predate drug abuse and promote denial of drug-related problems after addiction is established. While reduced connectivity with the rMFG may implicate some aspect of decision-making (Cao et al, 2015), it is less immediately clear how connectivity with regions important for vision (occipital lobes; Mesulam, 2000) and motor processing (precentral cortex; Mesulam, 2000) may play a role in denial. Additional research is needed to determine whether these patterns of connectivity play a causal role in denial or alternatively represent epiphenomena.…”

Section: Discussionmentioning

confidence: 99%

Denial in methamphetamine users: Associations with cognition and functional connectivity in brain

Dean¹,

Kohno²,

Morales³

et al. 2015

Drug and Alcohol Dependence

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Background Despite harmful consequences of drug addiction, it is common for individuals with substance use disorders to deny having problems with drugs. Emerging evidence suggests that some drug users lack insight into their behavior due to neurocognitive dysfunction, but little research has examined potential neurocognitive contributions to denial. Methods This study explored the relationship between denial, cognitive performance and functional connectivity in brain. The participants were 58 non-treatment-seeking, methamphetamine-dependent participants who completed the URICA Precontemplation scale, a self-report measure of denial of drug problems warranting change, as well as a cognitive test battery. A subset of participants (N=21) had functional MRI scans assessing resting-state functional connectivity. Given literature indicating roles of the rostral anterior cingulate (rACC), anterior insula and precuneus in self-awareness, relationships between denial and resting-state connectivity were tested using seeds placed in these regions. Results The results revealed a negative relationship between denial and an overall cognitive battery score (p=0.001), the effect being driven particularly by performance on tests of memory and executive function. Denial was negatively associated with strength of connectivity between the rACC and regions of the frontal lobe (precentral gyri, left ventromedial prefrontal cortex, left orbitofrontal cortex), limbic system (left amygdala, left hippocampus and left parahippocampal gyrus), occipital lobes and cerebellum; and between the precuneus and the midbrain and cerebellum. Anterior insula connectivity was unrelated to denial. Conclusions These findings suggest that denial by methamphetamine users is linked with a cognitive and neural phenotype that may impede the development of insight into their behavior.

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Abnormal regional homogeneity in young adult suicide attempters with no diagnosable psychiatric disorder: A resting state functional magnetic imaging study

Cited by 57 publications

References 62 publications

Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting from working memory training

Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting from working memory training

Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study

Denial in methamphetamine users: Associations with cognition and functional connectivity in brain

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