Abnormal Regulation of Renin Angiotensin Aldosterone System Is Associated With Right Ventricular Dysfunction in Hypertension

Gregori, Mario; Giammarioli, Benedetta; Befani, Alberto; Ciavarella, Giuseppino Massimo; Ferrucci, Andrea; Paneni, Francesco

doi:10.1016/j.cjca.2013.11.009

Cited by 16 publications

(10 citation statements)

References 28 publications

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“…The usage of tissue Doppler parameters (isovolumetric contraction time, systolic peak velocity of the RV free wall at the level of tricuspid valve), fractional area shortening (FAC), or TAPSE resulted in controversial results. Some authors found the deterioration of RV systolic function, some disagreed, and the others partly agreed . Interestingly, if myocardial performance index (Tei index) is used as a parameter of RV dysfunction, most investigations concur about the negative influence of arterial hypertension on RV systolic‐global function …”

Section: Rv Function In Arterial Hypertensionmentioning

confidence: 99%

“…23 Interestingly, if myocardial performance index (Tei index) is used as a parameter of RV dysfunction, most investigations concur about the negative influence of arterial hypertension on RV systolic-global function. 22 Unlike the uncertainty that exists in the relationship between arterial hypertension and RV systolic function, almost all investigators agree that arterial hypertension impacts RV diastolic function. [5][6][7][8][9][10][11][12] The evaluation of RV diastolic function was mainly performed by pulsed and/or tissue Doppler indices.…”

Section: Rv Function In Arterial Hypertensionmentioning

confidence: 99%

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Right heart remodeling induced by arterial hypertension: Could strain assessment be helpful?

Tadić

Cuspidi

Bombelli

2018

J of Clinical Hypertension

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Left ventricular structural and functional changes in patients with arterial hypertension are well established. However, the influence of arterial hypertension on right ventricular (RV) remodeling is still being investigated. The introduction of strain analysis provided an insight into RV function and mechanics. Previous research has demonstrated the predictive value of RV longitudinal strain in patients with various cardiovascular conditions, such as pulmonary hypertension, heart failure, congenital heart diseases, and valvular disease. Nowadays, we are aware of the fact that conventional echocardiographic methods usually do not provide necessary information about RV dysfunction in patients with arterial hypertension, which is why the evaluation of new parameters that could detect RV subtle changes in hypertension is essential. The present review article is an overview of the main principles of RV deformation and a summary of the current knowledge and clinical significance of RV strain in patients with arterial hypertension.

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Section: Rv Function In Arterial Hypertensionmentioning

confidence: 99%

Section: Rv Function In Arterial Hypertensionmentioning

confidence: 99%

Right heart remodeling induced by arterial hypertension: Could strain assessment be helpful?

Tadić

Cuspidi

Bombelli

2018

J of Clinical Hypertension

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“…6,7 However, recently published data indicated that angiotensin II, the main biologically active peptide of the RAS, contributed to lung cancer development and progression. 7,8 Accruing evidence suggests that divergence from the insertion (I) allele to the deletion (D) allele of this polymorphism is correlated with a higher plasma level of angiotensin-converting enzyme (ACE) activity. 10 Some studies have attempted to investigate the association between the ACE gene I/D polymorphism with lung cancer, but the results are often not reproducible.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] The RAS plays an important role in blood pressure and cardiovascular homeostasis. 6,7 However, recently published data indicated that angiotensin II, the main biologically active peptide of the RAS, contributed to lung cancer development and progression. 7,8 Accruing evidence suggests that divergence from the insertion (I) allele to the deletion (D) allele of this polymorphism is correlated with a higher plasma level of angiotensin-converting enzyme (ACE) activity.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between ACE insertion/deletion polymorphism and lung cancer: A meta-analysis

Cheng

Tan

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Previous case-control studies on the relation between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and lung cancer were controversial. In this study, we aimed to further evaluate the relation between the ACE gene I/D polymorphism and lung cancer. Methods: We selected eight case-control studies related to the ACE gene I/D polymorphism and lung cancer by searching PubMed, EMBase, Chinese Biomedical Literature Database, and Wanfang database. We utilized Q-test and I 2 test to test the heterogeneity between each study. To merge the odds ratio (OR) and 95% confidence interval, we utilized the fixed-effects model during the analyses. Results: The present study included 1612 patients with lung cancer and 1442 cancer-free control subjects. By metaanalysis, we did not find any association between the ACE gene I/D polymorphism and lung cancer in either genotype or allele distribution (DD vs. (ID+II): OR = 0.96, 95% CI (0.80-1.14), p = 0. 61; D allele vs. I allele: OR = 1.01, 95% CI (0.91-1.13), p = 0.79). Conclusion:We concluded that the ACE gene I/D polymorphism was not associated with lung cancer.

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“…Thus, we sought to ascertain the cardioprotective potential of silencing Wipi1 in an in vitro model of HF and its effect on RVF-associated drivers. Specifically, we cultured isolated neonatal rat ventricular myocytes (NRVMs) with aldosterone to mimic the neurohormonal activation predominantly associated with RV dysfunction and failure (23)(24)(25)(26). In control NRVMs transfected with nontargeting siRNA (si-Scramble), neurohormonal stimulation with aldosterone significantly increased the expression of Nppa, Nppb, Acta1, and Myh7, consistent with induction of the fetal gene program in HF (Supplemental Figure 2).…”

Section: Resultsmentioning

confidence: 89%

WIPI1 is a conserved mediator of right ventricular failure

Tzimas¹,

Rau²,

Buergisser³

et al. 2019

JCI Insight

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Abnormal Regulation of Renin Angiotensin Aldosterone System Is Associated With Right Ventricular Dysfunction in Hypertension

Cited by 16 publications

References 28 publications

Right heart remodeling induced by arterial hypertension: Could strain assessment be helpful?

Right heart remodeling induced by arterial hypertension: Could strain assessment be helpful?

Lack of association between ACE insertion/deletion polymorphism and lung cancer: A meta-analysis

WIPI1 is a conserved mediator of right ventricular failure

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